Hematological and biochemical blood indices of dogs when using «Neoverm» and protectors-antioxidants


  • I.O. Zhukova Kharkov state zooveterinary academy, Akademichna Str., 1, Mala Danylivka, Kharkiv region, Dergachi district, 62341
  • I.O. Kostyuk
  • Yu.S. Svitlychna-Kulak
Keywords: Neoverm, dogs, E-Selenium, Quercetin, Lesphal, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gammaglutamyltransferase, raw buckwheat grain, buckwheat green

Abstract

The article presents the data on the effect of antihelmintic and imunomodulating drug «Neoverm» on the dogs’ body when the drug was administered into the stomach of the animals within three days and the results of its application in the combination with the drugs that contain antioxidant and membrane stabilizing substances. To protect the body from toxic action of «Neoverm» the drugs were used under two schemes: «E-Selenium» and «Quercetin», phospholipid hepaprotector «Lesphal» and «green buckwheat» (a feed additive – pre-ground raw buckwheat as a natural source of quercetin). The result a were compared with the control group and the group that received only «Neoverm». It has been found out that the use of «Neoverm» for the dogs both on the 7th and 14th days had a negative impact on the hematological parameters and the activity of blood enzymes that reflects the functional state of the liver. In particular, the reduction in the number of erythrocytes and the level of hemoglobin as well as the significant increase in the activity of diagnostic enzymes: alanine (ALT), asparagine (AST), gammaglutamyl (GGT) transferases and alkaline phosphatase (ALP) have been revealed. The proposed schemes to correct the toxic effect of the drug «Neoverm» in dogs led to the restoration of endogenous antitoxic resources, that is, to a gradual normalization of hematological parameters and the activity of indicatory enzymes of blood (the decrease in the activity of AST, ALT, GGT, ALP and LDH and the normalization of the number of red blood cells and hemoglobin) and that is the basis for the use of the above drugs as protectors-antioxidants when «Neoverm» is used.

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References

Berezovskyi, A.V. (2000). Likoopirnist zooparazytiv ta deiaki shliakhy yii podolannia. Veterynarna medytsyna Ukrainy. 3, 33–34 (in Ukrainian).

Tishyn, O.L. (2015). Farmako-toksykodynamika kompleksnoho protyparazytarnoho preparatu na osnovi aversektynu S i klozantelu ta odyn iz shliakhiv zmenshennia yoho pobichnoho vplyvu: avtoref. dys. … doktora veter. nauk, 40 (in Ukrainian).

Lystivka-vkladka dlia zastosuvannia neovermu. – TOV «AT Biofarm», 2013.(in Ukrainian).

Zhukova, I.O., Svitlychna-Kulak, Yu.S., Lonhus, N.I. (2016). Korektsiia stanu antyoksydantnoho zakhystu u sobak za otruiennia neovermom. Naukovyi visnyk LNUVMBT imeni S.Z Hzhytskoho. 18, 3(70), 95–99 (in Ukrainian).

Zabolockij, V.T., Poljakov, V.F. (1965). Metodika podscheta jeritrocitov na kolorimetre tipa FJeK-M. Tr. Vsesojuz. in-ta jeksperim. veterinarii. 31, 281–286 (in Russian).

Kondrahin, I.P., Kurilov, N.V., Malahov, A.G. (1985). Klinicheskaja laboratornaja diagnostika v veterinarii : spravochnoe izdanie. M.: Agropromizdat, 143–145 (in Russian).

Mahan'ko, A.V., Gerasimenko, V.G. (1974). Tablicy dlja opredelenija cvetnogo pokazatelja i soderzhanija gemoglobina v jeritrocite sel'skohozjajstvennyh zhivotnyh. K.: Urozhaj (in Russian).

Kamyshnikov, V.S. (2003). Kliniko-biohimicheskaja laboratornaja diagnostika : Spravochnik: V 2 t. Mn: Interpresservis, 1 (in Russian).

Metod vyznachennia aktyvnosti luzhnoi fosfatazy u syrovattsi krovi ta tkanynakh : prospekt firmy «Filisit Diahnostyka» (Ukraina), 2 (in Ukrainian).

Vyznachennia aktyvnosti alanin- i aspartamaminotransferaz u syrovattsi krovi ta tkanynakh metodom AlAT-mikro ta AsAT-mikro : prospekt firmy «Filisit Diahnostyka» (Ukraina), 2 (in Ukrainian).

Metod vyznachennia aktyvnosti hamma-hlutamiltransferazy: prospekt firmy «PLIVA-Lachema Diagnostika» s.r.o. Karasek 1, 621 33 Brno, CZ, 2 .(in Ukrainian).

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Published
2017-02-07
How to Cite
Zhukova, I., Kostyuk, I., & Svitlychna-Kulak, Y. (2017). Hematological and biochemical blood indices of dogs when using «Neoverm» and protectors-antioxidants. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(73), 46-49. https://doi.org/10.15421/nvlvet7310