Research of sharp and chronic toxicness of experimental preparation of «Ferosel Т»


  • V. Todoriuk
  • V. Hunchak
  • D. Gufrij
  • B. Gutyj
  • I. Hariv
  • R. Khomyk
  • R. Vasiv
  • N. Slobodyuk
  • A. Vynyarska
  • O. Zhuravlоv
  • P. Husar
  • N.V. Nazaruk
  • N.Y. Nazaruk
  • M. Soltis
Keywords: pharmacology, toxicology, Ferosel Т, Iron, Selenium, rat, rabbit, guinea-pigs

Abstract

In the article the brought results over of sharp and chronic toxicness of new preparation dextran of iron «Ferosel Т», that in the composition contains Iron and Selenium. It was set that preparation of «Ferosel Т» in prophylactic and therapeutic doses and in a dose in 3 times of any more than therapeutic, at peroral introduction a 3 twenty-four hours in succession did not show a toxic action laboratory rats. At the terms of hypodermic introduction of preparation the death of white rats it was not, it is only set brief oppression of laboratory animals, animals preparations were given that in a dose 10 ml/kg. It is set that in prophylactic and optimal therapeutic doses preparation did not influence on the detoxication function of liver. For rats, what was entered Ferosel T in maximal therapeutic and maybe toxic doses, duration of a dream from Hexenalum was on 32 and 35 percents more relation than control sizes. The toxicness of Ferosel Т was also studied on the indexes of irritating action(after dermic test and testis on conjunctiva), action of allergy (a method of applique on a skin) and determined the coefficients of mass of internalss at great while of introduction of preparation. For animals Ferosel Т was entered that in a dose 10 ml/kg during a 21 twenty-four hours, motive activity some went down. Research of emotional and behavior reactions of laboratory animals after introduction of Ferosel Т during a 21 twenty-four hours in therapeutic and maximally therapeutic doses did not show substantial influence on the nervous system. On the indexes of hyperemia and edema of skin and thickness of skin fold of Ferosel Т in prophylactic and therapeutic doses at an applique on the skin of crawls did not cause a local irritating action. Separate injection of preparation of «Ferosel Т» for 0,1 ml did not cause the filling out reaction of paws guinea-pigs. As a result of undertaken studies it is not educed allergen properties at preparation of «Ferosel Т». For laboratory rats, Ferosel Т was entered that in a prophylactic dose it is not set reliable changes of coefficients of mass of heart, liver, spleen and kidneys. For rats Ferosel Т was entered that in an optimal therapeutic dose, in comparing to control mass of spleen and liver was accordingly on 10.3 and 6.4% anymore. At introduction of Ferosel Т to the maximally therapeutic dose mass of spleen and liver was accordingly on 14.0 and 15.0% anymore. The got results of researches specify that preparation of Ferosel Т is safe at application for a prophylaxis and treatment of animals.

Downloads

Download data is not yet available.

References

Petrov, V.M., Anan'ev, P.K. (1982). Profilaktika zabolevanij molodnjaka sel's'kohozjajstvennyh zhivotnyh v promyshlennyh kompleksah. Alma-Ata: Bagration, 50–64 (in Russian).

Toksykolohichnyi kontrol novykh zasobiv zakhystu tvaryn (Metodychni rekomendatsii) (1996). Holovnym upravlinniam veterynarnoi medytsyny Min. Silhospprodu Ukrainy. Kyiv, 33 (in Ukrainian).

Gutyj, B., Paska, M., Levkivska, N., Pelenyo, R., Nazaruk, N., Guta, Z. (2016). Study of acute and chronic toxicity of ‘injectable mevesel’ investigational drug. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6(2), 174–180. doi: http://dx.doi.org/10.15421/201649

Gutyj, B., Khariv, I., Binkevych, V., Binkevych, O., Levkivska, N., Levkivskyj, D., Vavrysevich, Y. (2017). Research on acute and chronic toxity of the experimental drug Аmprolinsyl. Regul. Mech. Biosyst. 8(1), 41–45.

Khariv, M., Gutyj, B., Butsyak, V., Khariv, I. (2016). Hematological indices of rat organisms under conditions of oxidative stress and liposomal preparation action. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6 (1), 276–289. doi: http://dx.doi.org/10.15421/201615

Martyshuk, T.V., Gutyj, B.V., Vishchur, O.I. (2016). Level of lipid peroxidation products in the blood of rats under the influence of oxidative stress and under the action of liposomal preparation of «Butaselmevit», Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6(2), 22–27. doi: http://dx.doi.org/10.15421/201631

Todoriuk, V.B. (2012). Vplyw preparatu Minbivitu na profilacticu anernii porosat [Influence of Minbevit on the prevention of anemia of piglets]. Nauc. Visnic LNUVMВТ — Research Bulletin LNUVMIВТ. 14, 3(53), 273–278 (in Ukrainian).

Todoriuk, V.B., Gutyj, B.V., Khomyk, R.I., Vasiv, R.O. (2016). Influence of ferrovet 7.5% and ferosel T on the concentration of mineral substances in the blood serum of piglets suffering from Iron deficit anemia. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj. 18, 3(71), 139–143.

Rozin, D.G. (1964). Modern evaluation of toxicity chlorproductive carbohydrates of fatty raw yder gexanal test with white mice. Pharmacology and toxicology. 5, 613–614.

Abstract views: 153
PDF Downloads: 154
Published
2017-01-13
How to Cite
Todoriuk, V., Hunchak, V., Gufrij, D., Gutyj, B., Hariv, I., Khomyk, R., Vasiv, R., Slobodyuk, N., Vynyarska, A., ZhuravlоvO., Husar, P., Nazaruk, N., Nazaruk, N., & Soltis, M. (2017). Research of sharp and chronic toxicness of experimental preparation of «Ferosel Т». Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(73), 104-111. https://doi.org/10.15421/nvlvet7322

Most read articles by the same author(s)