Microscopic structure and morphometric parameters pancreatic dogs in postnatal ontogenesis
AbstractThe work on the basis of anatomical, histological, morfmetric and statistical research methods found histomorphology of pancreas in clinically healthy dogs at a postnatal ontogenesis. It was found that in the process of growth and development of animals sheer mass (AM) of the pancreas increased from 1.44 ± 0.64 g daily puppies to age 29.83 ± 3.0 g dogs 3–4 years of age. The most intensive growth options of pancreas observed to 8 months of age. Relative body weight with age, on the contrary, decreases. Histological structure of pancreas consists of individual particles composed of exocrine and endocrine parts. Exocrine part of the pancreas by morphometric studies conducted occupies the bulk of the parenchyma of the organ - the area of neonatal puppies is 99.49 ± 0.04%. From the age of exocrine gland parenchyma decreases in mature dogs is 98.55 ± 0.07%. The structural unit of the exocrine part is round or oval pancreatic acini, which built a wall pancreatocytes. The latter are elongated or prismatic shape and distinct polar differentiation – basal and apical zones. Pancreatocytes volume increases with age animals from 353.33 ± 12.91 mkm3 in one day puppies to 507.84 ± 25.06 mkm3 3–4-year-old dog, which leads to changes in the nuclear-cytoplasmic ratio, which in newborn puppies 1-day of age is 0.139 ± 0.01 conv. units in mature dogs – 0.089 ± 0.01 conv. units, respectively, decreasing to (Р < 0.001) 1.56 times, and shows Morphofunctional pancreatocytes activity. Endocrine part of pancreas occupies a small area, respectively, in 1-day puppies is 0.51 ± 0.04%, in dogs 3–4 years of age – 1.45 ± 0.07%. It is represented by small clusters of cells round or oval, which form pancreatic islets (islets of Langerhans) in diameter puppies one day age is 35.31 ± 0.39 mm. in mature dogs – 36.65 ± 0.13 mm.
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