Pathomorphological characteristics of coronavirus infection in dogs


  • V. Lisova National University of life and environmental sciences of Ukraine
  • O. Dubinenko National University of life and environmental sciences of Ukraine
Keywords: dogs, coronavirus infection, gross changes, serous-fibrinous jejuno-ileitis, hemorrhage, cachexy, dehydration

Abstract

The results of the study of the morphological features of pathological processes in organs and tissues of dogs with coronavirus infection. The study of cadavers (n = 3) dogs of different breeds and sex between the ages of 2 to 6 months, who died with diarrheal syndrome. Presence of coronavirus, without other assiociants, in these cases had previously been confirmed in the polymerase chain reaction analysis of fecal samples. At this stage, the main method of our study was mortem autopsy. At autopsy, which was carried out in partial evisceration, recorded and described the macroscopic changes identified in various tissues and organs of dead dogs and selected pathological material for subsequent histological examination. It is shown that the most pronounced lesions and typical change in all dead dogs fixed contact in the small intestine (jejunum and to the ileum) and the regional lymph nodes to it, as well as in the spleen. It is shown that the morphological manifestations of coronavirus infection in dogs following features are on the macroscopic level: the presence of exudative inflammation in the small intestine in the form serous-fibrinous jejuno-ileitis; hyperplasia and serous-hemorrhagic lymphadenitis mesenteric lymph nodes; multiple foci of hemorrhage of different character (spotted and striped) in the parenchyma of the spleen and serous membrane of the small intestine; dilatation of the right ventricle of the heart; cachexy and dehydration due to diarrheal syndrome. Also, non-specific, but constant morphological features, which arose as a result of circulatory disorders and heart failure were: passive venous congestion of the liver, kidney and pulmonary edema; degenerative processes in the liver. In one case, we identified morphological features characteristic of serous-inflammatory swelling of the pancreas and pathological changes in the myocardium that are typical of concentric hypertrophy of left ventricular heart. These pathological processes can be considered a complication that developed as a result of the underlying disease.

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References

Gizzi, A.B.R., Oliveira, S.T., Leutenegger, C.M. et al. (2014). Presence of infectious agents and co-infections in diarrheic dogs determined with a real-time polymerase chain reaction-based panel. BMC Veterinary research, 6, 81‒90.

Radzykhovsʹkyy, M.L. (2016). Monitorynh enterytiv virusnoyi etiologiyi u sobak [Monitoring enteritis viral etiology in dogs].Scientific Journal of National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytsky, 18, 1 (65), 1, 138‒142 (in Ukrainian).

Wang, X., Li, C., Guo, D. (2016). Co-Circulation of Canine Coronavirus I and IIa/b with High Prevalence and Genetic Diversity in Heilongjiang Province, Northeast China. Available at : http://journals.plos.org/plosone/ article?id=10.1371/journal.pone.0146975

Jeoung, S.Y., Ann, S.Y., Kim, H.T., Kim, D. (2014). M gene analysis of canine coronavirus strains detected in Korea. J Vet Sci. 15, 495–502.

Soma, T., Ohinata, T., Ishii, H. et al. (2011). Detection and genotyping of canine coronavirus RNA in diarrheic dogs in Japan. Res Vet Sci. 90, 205–207.

Costa, E.M., de Castro, T.X., Bottino Fde, O., Garcia Rde, C. (2014). Molecular characterization of canine coronavirus strains circulating in Brazil. Vet Microbiol. 168, 8–15.

Ntafis, V., Mari, V., Decaro, N. et al. (2013). Canine coronavirus, Greece. Molecular analysis and genetic diversity characterization. Infect Genet Evol. 16, 129–136.

Decaro, N., Desario, C., Billi, M. et al. (2011). Western European epidemiological survey for parvovirus and coronavirus infections in dogs. Vet. J. 187, 195–199.

Decaro, N., Buonavoglia, C. (2008). An update on canine coronaviruses: viral evolution and pathobiology. Vet Microbiol. 10, 132(3–4), 221–234.

Decaro, N., Viviana M. et al. (2012). A pantropic canine coronavirus genetically related to the prototype isolate CB/05. Vet Microbiol. 159, 1–2, 239–244.

Erles, K., Brownlie, J. (2008). Canine Respiratory Coronavirus: An Emerging Pathogen in the Canine Infectious Respiratory Disease Complex. Veterinary Clinics of North America: Small Animal Practice. 38(4), 815–825.

Zappulli, V., Caliari, D., Cavicchioli, L. et al. (2008). Systemic fatal type II coronavirus infection in a dog: Pathological findings and immunohistochemistry. Research in Veterinary Science. 84(2), 278–282.

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Published
2017-03-12
How to Cite
Lisova, V., & Dubinenko, O. (2017). Pathomorphological characteristics of coronavirus infection in dogs. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(77), 7-10. https://doi.org/10.15421/nvlvet7702