Indicators of protein-lipid exchange for hepatostateatosis


  • O.O. Smirnov
  • Yu.V. Spivak
  • M.S. Smirnova
  • L.H. Kalachniuk
Keywords: γ-glutamyltransferase, bilirubin, triacylglycerols, cholesterol, LDL, HDL, blood, rats

Abstract

Our previous experimental data have shown that some indices of lipid metabolism are increased under conditions of development alcohol-induced hepatic steatosis. There are distractive changes metabolic processes (especially lipid and protein metabolism) caused by alcohol. There are some publications about S-containing bioprotectors influence on organism, those works are under discussion.

This work is devoted to the study of changes of some indices of protein-lipid metabolism in the blood of rats with alcohol-induced hepatic steatosis and after treatment of S-containing biological protector betaine.

One of the main indicators of the development of alcohol-induced hepatic steatosis is the increasing activity of γ-glutamyltransferase. Under the conditions of alcohol-induced hepatic steatosis in the blood serum of rats, the activity of GGT increases in 3 times, and at the same time, the using bioprotector decreases enzymatic activity to the level of control.Changes in the activity of GGT are in direct correlation with changes in levels of bilirubin, triacylglycerol and cholesterol levels.

The study of the effect of Sulfur-containing bioprotector requires a more detailed investigation of metabolic processes in the animal organism, especially protein-lipid metabolism, in order to correct pathological deviations caused by alcohol-induced hepatic steatosis.

 

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References

Kalachniuk, L.H., Melnychuk, D.O., Kalachniuk, H.I., Sukhorska, O.P., Savka, O.H. (2007). Biosyntez tryatsylhlitseroliv u pechintsi za umov alkoholnoi intoksykatsii ta vplyvu ekzohennykh fosfolipidnykh kompleksiv. Nauk. visnyk LNAVM im. S.Z. Gzhytskoho. 9, (32), 279–286 (in Ukrainian).

Kalachniuk, L.H. (2016). Molekuliarni mekhanizmy rehuliatsii metabolichnykh protsesiv za dii ekzohennykh chynnykiv (monohrafiia). K: Komprynt (in Ukrainian).

Kalachniuk, L.H., Arnauta, O.V. (2015). Teoretychni ta metodychni zasady vyvchennia metabolichnykh protsesiv u tvaryn i liudyny za pokaznykamy krovi : navchalnyi posibnyk. Kyiv (in Ukrainian).

Cederbaum, A.I. (2010). Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol. 16, 1366–1376.

Szary, N. (2015). High intrinsic aerobic capacity protects against ethanol-induced hepatic injury and metabolic dysfunction: study using high capacity runner rat model. Biomolecules. 5(4), 3295–3308.

Abstract views: 37
PDF Downloads: 25
Published
2017-04-03
How to Cite
Smirnov, O., Spivak, Y., Smirnova, M., & Kalachniuk, L. (2017). Indicators of protein-lipid exchange for hepatostateatosis. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(78), 191-193. Retrieved from https://nvlvet.com.ua/index.php/journal/article/view/1323