Morphological characteristics of sheep placenta during fetoplacental insufficiency and correction with the preparation «Karaphest + OV»


  • I.O. Ostroverkhova
  • O.E. Zhigalova
Keywords: sheep, placenta, fetoplacental insufficiency, morphology, histostructure, newborn lambs, correction, Karaphest OV

Abstract

The purpose of the work was to investigate the morphological and histological changes of placenta in fetoplacental insufficiency. To achieve this goal, we investigated the cellular composition of the vaginal smear of pregnant sheeps, conducted some biochemical studies of homeostasis, macro-and microscopic examination of the sheep placenta itself with fetolacenter insufficiency and correction of the complex drug «Karaphest + OV». According to the results of the research, it was found that in the blood of sheep of the II group, the clinical and biochemical parameters significantly differed from those of the animals of the I group. The established tendency testifies to the presence of metabolic disorders in their body. At macroscopic examination it was found that the investigated placent from the sheep of both groups were shiny and well-vascularized without pathological stratifications. Cotyledons of the control group had less pronounced relief, in some of them local hemorrhages were determined. At the same time, the body weight of newborn lambs in the experimental group was significantly higher than in the control group – by 44.2%, and the mass of the placenta – by 15.9%. There was also an increase in the number of cotyledons by 4.1%, and their total area was greater by 29.3%. This indicates a significant lagging development of the fetus in conditions of functional insufficiency of the fetoplacental complex. Histologic research has established that during fetoplacental insufficiency there are hemodynamic disorders and dystrophic changes on the part of stroma, syncytiotrophoblast and cytotrophoblast of chorionic villi. Structural changes in the fetal part of the placenta of the control group lead to hypoxia of the fetus, insufficient provision of its trophic and excretory needs, which may cause autointoxication. The drug «Karaphest + OV» has a positive effect on the structure of the placenta and the development of the fetus, first of all, it is the improvement of placental perfusion, increasing the number of blood vessels in the stem wings, the preservation of the layers of cytotrophoblast and syncytiotrophoblast, which exhibit the ability to resorb blood and hemosiderin from intervertebral space, which significantly improves the metabolism of the fetuses and the maternal parts of the placenta. As a result of our research, we arrived at the following conclusions that correction of fetoplacental insufficiency with the use of the drug «Karaphest + OV» reduces the manifestation of dystrophic processes, normalizes angiogenesis in the villous part of the chorion, contributes to the restoration of the villous of the trophoblast.

 

Downloads

Download data is not yet available.

References

Bubnova, N.I. Tjutjunnik, V.L., Mihajlova, O.I. (2010). Reproduktivnye poteri pri dekompensirovannoj placentarnoj nedostatochnosti, vyzvannoj infekciej. Akusherstvo i ginekologija. 4, 55–58 (in Russian).

Malashko, V.V., Trockaja, N.V., Skudnaja, T.M. (2005). Gipotrofija novorozhdennogo molodnjaka sel'skohozjajstvennyh zhivotnyh i puti realizacii kompensatornyh vozmozhnostej organizma. Sel'skoe hozjajstvo – problemy i perspektivy: sbornik nauchnyh trudov. Grodno. 4(2), 98–101 (in Russian).

Milovanov, A.P. (2007). Funkcional'naja morfologija i mehanizmy reguljacii matochno–placentarnogo krovoobrashhenija. Vestn. Ros. associacii akusherov-ginekologov. 3, 109–115 (in Russian).

Fong, K.W., Ohlsson, A., Hannah, M. (1999). Prediction of Perinatal Outcome in fetuses Suspected to Have Intrauterine Growth Restriction: Doppler US Study of Fetal Cerebral, Renal and Umbilical Arteries. Radiolidy, 681–688.

Skliarov, P.M., Koshovyi, V.P. (2006). Otsinka morfo–funktsionalnoho stanu ta rozrobka zakhodiv pidvyshchennia zhyttiezdatnosti novonarodzhenykh yahniat. Visnyk Sumskoho NAU. 1–2 (15–16), 176–180 (in Ukrainian).

Chub, V.V., Chibisova, I.V., Klimov, V.A. (2003). Fetoplacentarnaja disfunkcija: osnovy patogeneza, problemy diagnostiki, taktika lechenija. Metodicheskie rekomendacii. Lugansk (in Russian).

Koshevoi, V.P., Fedorenko, S.Ia., Naumenko, S.V. (2016). Kompleksni preparaty, stvoreni na osnovi nano-biomaterialiv ta yikh vykorystannia u veterynarnii reproduktolohii (metodychni rekomendatsii). Dnipropetrovsk: vydavnytstvo «Porohy» (in Ukrainian).

Koshevoi, V.P., Fedorenko, S.Ia., Velychko, O.V., Skliarov, P.P., Ivanchenko, M.M., Besedovska, K.S., Maliukin, Yu.V., Klochkov, V.K. (2015). TU TUU 24.4-1452420732-004:2015 na preparat «Karafest+OV». Lviv (in Ukrainian).

Abstract views: 43
PDF Downloads: 84
Published
2017-11-05
How to Cite
Ostroverkhova, I., & Zhigalova, O. (2017). Morphological characteristics of sheep placenta during fetoplacental insufficiency and correction with the preparation «Karaphest + OV». Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(82), 153-158. Retrieved from https://nvlvet.com.ua/index.php/journal/article/view/1356