Equine gastric ulcer syndrome (EGUS). Prevalence, etiology, diagnostic


Keywords: horses, gastrointestinal tract diseases, ulcer, gastroscopy, Helicobacter spp

Abstract

The analysis of scientific literature and different studies of recent years concerning diseases of the stomach in horses has been conducted in the article. The analysis of literature data indicates that the Equine gastric ulcer syndrome is a common disease especially among racehorses. This term is a condition in horses, characterized by ulcers in the terminal esophagus; proximal (squamous) stomach; distal (glandular) stomach; and proximal duodenum. The anatomy and physiology of the stomach, with particular reference to secretion of acid and mucosal protective mechanisms, are reviewed as well as the differing theories relating to the aetiopathogenesis of gastric ulceration. The prevalence of the disease in racehorses has been reported from 60 to 90%. In general, horses that are in active training for racing tend to have a prevalence of around 90%, whereas horses for pleasure in full work have a reported prevalence of approximately 60%. The recent years data indicate the influence of microorganism Helicobacter genus on ulceration in equine stomach, a new specific species of H. Equorum was identified by the PCR assay in horse faeces, but the relationship between different species of Helicobacter and stomach ulcers remains controversial. Recently, nutritional and dietary management factors, the features of the anatomical structure of the stomach, dental problems, nonsteroidal anti-inflammatory drugs etc. have been identified to play an important role in gastric ulceration in horses. Clinical signs of EGUS are not always noticeable. Depending on the degree of damage, сlinical signs in horses with EGUS include: acute and recurrent colic, poor body condition, partial anorexia, poor appetite, poor performance and attitude changes, diarrhea,, the disease is accompanied by weight loss, loss of appetite and decreased ability to work. This disease affects the physical condition of horses, slows the growth and development of foals. The introduction of new diagnostic tests and methods in veterinary practice, including gastroscopy, allows to diagnose ulcers on early stages, investigate and explore the causes of EGUS. The diagnosis requires a thorough treatment history, physical examination, and a minimum database. Identifying risk factors and clinical signs are also helpful in making a diagnosis. However, gastroscopy is the only definitive diagnosis for gastric ulcers currently available. in more detail. The article presents a 0‒5 gastric ulcer scoring system to determine a lesion prevelence.

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References

Slivinska, L.H., Drachuk, A.O., Demydiuk, S.K., Lychuk, M.H., & Shcherbatyi, A.R. (2013). Navchalno-metodychnyi posibnyk Koliky u konei, (etiolohiia, diahnostyka, likuvannia, profilaktyka (іn Ukrainian).

Zhanchipova, B.B. (2010). Izmeneniia sekretorno-motornoi funktcii zheludka loshadi pri ostrom razshirenii. Avtoreferat dissertacii na soiskanie uchenoj stepeni kandidata veterinarnyh nauk 06.02.01 – diagnostika boleznej i terapija zhivotnyh, patologija, onkologija i morfologija zhivotnyh. g.Barnaul (іn Russian).

Rabuffo, T.S., Hackett, E.S., Grenager, N., Boston, R., & Orsini J.A. (2009). Prevalence of Gastric Ulcerations in Horses with Colic. Acvsd. 540 Journal of Equine Veterinary Science. 29 (6), 540–546. doi: 10.1016/j.jevs.2009.05.005.

Rabuffo, T.S., Orsini, J.A., Sullivan, E., Engiles, J., Norman T., & Boston R. (2002). Association between age or sex and prevalence of gastric ulceration in Standardbred racehorses in training. Journal of the American Veterinary Medical Association. 221, 1156–1159. https://www.ncbi.nlm.nih.gov/pubmed/ 12387386.

Dionne, R.M., Vrins, A.A., & Doucet, M.Y. (2003). Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors. Journal of Veterinary Internal Medicine. 17(2), 218–222. https://www.ncbi.nlm.nih.gov/pubmed/12683624.

Kurdeko, A.P. (2016). Sovershenstvovanie diagnostiki i lecheniia iazvennoi bolezni zheludka loshadei. Naukovii vіsnik veterinarnoї meditcini. 2, 51‒56 (in Belarus).

Nieto, J. (2014). Gastrointestinal diseases of athletic horses. Equine Sports Medicine and Surgery (Second Edition). 999‒1009. doi: 10.1016/B978-0-7020-4771-8.00047-8.

Andrews F.M,. Bernard W., & Cohen H. (1999). Recommendations for the diagnosis and treatment of equine gastric ulcer syndrom (EGUS). Eq. Vet. Edu. 11(5), 262–272. doi: 10.1111/j.2042-3292.1999.tb00961.x.

Mazurkevych, A.I., Karpovskyi, V.I., Kambur, M.D., Trokoz, V.O., Stepchenko, L.M., Bublyk, V.M., & Holovach, P.I. (2012). Fiziolohiia Tvaryn. Vinnytsia: Nova Knyha (in Ukrainian).

Ross, I.N., Bahari, H.M., & Turneberg, L.A. (1981). The ph gradient across mucus adherent to rat fundic mucosa in vivo and the effect of potential damaging agents. Gastroenterology. 81(4), 713–718. https://www.ncbi.nlm.nih.gov/pubmed/7262515.

Cambell-Thompson, M.L, & Merritt, A.M. (1990). Basal and pentagastrin-stimulated gastric secretion in young horses. Am. J. Phys. 259(6), 1259–1266. doi: 10.1152/ajpregu.1990.259.6.R1259.

Levchenko, V.I., Kondrakhin, I.P., Vlizlo, V.V., Holovakha, V.I, Sudakov, M.O., Melnyk, Y.L., & Chumachenko, V.Iu. (2012). Vnutrishni khvoroby tvaryn. Pidruchnyk (іn Ukrainian).

Robinson, E. (2007). Bolezni loshadei, sovremennie metody lecheniia. Akvarium (in Russian).

Nado, D., & Frenk, M. (2007). Endrius. Sindrom iazvy zheludka (in Russian).

Contreras, M., Morales, A., Garcı a-Amado, M.A., De Vera, M., Bermu, V., & Gueneau, P. (2007). Detection of Helicobacter-like DNA in the gastric mucosa of Thoroughbred horses. Letters in Applied Microbiology. 5(45), 553‒557. doi: 10.1111/j.1472-765X.2007.02227.x.

Macallister, C.G., Andrews, F.M., Deegan. E., Ruoff. W., & Olovson. S.G. (1997). A scoring system for gastric ulcers in the horse. Equine Veterinary Journal. 29(6), 430‒433. https://www.ncbi.nlm.nih.gov/pubmed/ 9413714.

Sandin, A., Skidell, J., Haggstrom, J., & Nilsson, G. (2003). Postmortem findings of gastric ulcers in Swedish horses older than age one year: A retrospective study of 3715 horses. Equine Veterinary Journal. 32(1), 36–42. https://www.ncbi.nlm.nih.gov/ pubmed/10661383.

Bell, R.J., Mogg, T.D., & Kingston, J.K. (2007). Equine gastric ulcer syndrome in adult horses: A review. New Zealand Veterinary Journal. 1(55), 1‒12. doi: 10.1080/00480169.2007.36728.

Murray, M.J., & Eichorn, E.S. (1996). Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confi nement with ad libitum access to hay on gastric ulceration in horses. American Journal of Veterinary Research. 57(11), 1599–1603. https://www.ncbi.nlm. nih.gov/pubmed/8915437

Bell, R.J., Kingston, J.K., Mogg, T.D., & Perkins, N.R. (2007). The prevalence of gastric ulceration in racehorses in New Zealand. New Zealand Veterinary Journal 55(1). 13–18. doi: 10.1080/00480169.2007.36729.

Andrews, F.M., & Nadeau, J.A. (1999). Clinical syndromes of gastric ulceration in foals and mature horses. Equine Veterinary Journal. 39(S29), 30–33. doi: 10.1111/j.2042-3306.1999.tb05165.x.

Reese, R.E., & Andrews, F.M. (2009). Nutrition and Dietary Management of Equine Gastric Ulcer Syndrome. 25(1), 79‒92. doi: 10.1016/j.cveq.2008.11.004.

Robinson, E. (2007). Bolezni loshadei, sovremennie metody lecheniia. Akvarium; 1008. Prisposobleniia dlia ispravleniia anomalii prikusa Tomas Dzh. Dzhonson; pod red. Entoni T. Bliksleigera. Grass Leik, Michigan (іn Russian).

Allen, T. (2003). Incorporating Equine Dentistry Into Your Practice. Journal of Equine Veterinary Science. 5, 198.

Murray, M.J. (1997). Suppression of gastric acidity in horses. Journal of the American Veterinary Medical Association. 11, 37–40. https://www.ncbi.nlm.nih. gov/pubmed/9215408.

Bezdekova, B., Jahn, P., & Vyskocil, M. (2008). Gastric ulceration, appetite, and feeding practices in standardbred racehorses in the Czech Republic. Acta Vet Brno. 77. 603‒607. doi: 10.2754/avb200877040603.

Videla, R., & Andrews, F.М. (2009). New Perspectives in Equine Gastric Ulcer Syndrome. Vet. Clin. Equine. 25(2), 283‒301. doi: 10.1016/j.cveq.2009.04.013.

Buchanan, B.R., & Andrews, F.M. (2003). Treatment and prevention of equine gastric ulcer syndrome. Veterinary Clinics of North America. Equine Practice. 19, 575–597. doi: 10.1016/j.cveq.2003.08.012.

Smyth, G.B., Young, D.W., & Hammond, L.S. (1989). Effects of diet and feeding on postprandial serum gastrin and insulin concentration in adult horses. Equine Veterinary Journal. 7, 56–59. https://www.ncbi.nlm.nih.gov/pubmed/9118108.

Hammond, C.J, Mason, D.K, & Watkins, K.L. (1986). Gastric ulceration in mature thoroughbred horses. Equine Vet. J. 18(4), 284–287. https://www.ncbi.nlm.nih.gov/pubmed/3758006.

Material z vikipedii, vilnoi entsyklopedii . Helicobacter Pylory: Istoriia vidkryttia, budova. Ostannie redahuvannia 8 hrud. 2016. https://uk.wikipedia.org /wiki/Helicobacter_pylori (in Ukrainian).

Blaser, M.J. (2005). An Endangered Species in the Stomach. Scientific American. 292(2), 38–45. https://www.ncbi.nlm.nih.gov/pubmed/15715390.

Bizzozero, G. (1893). Ueber die schlauchförmigen Drüsen des Magendarmkanals und die Beziehungen ihres Epitheles zu dem Oberflächenepithel der Schleimhaut. Archiv für mikroskopische Anatomie. 42, 82–152.

Konturek, J.W. (2003). Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer. J. Physiol. Pharmacol. 54(3), 23–41. https://www.ncbi.nlm. nih.gov/pubmed/15075463.

Marshall, B.J., & Warren, J.R. (1984). Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration. Lancet 1, 8390, 1311–1315. https://www.ncbi.nlm.nih.gov/pubmed/6145023.

Scott, D.R., Marcus, E.A., Shirazi-Beechey, S.S.P., & Murray, M.J. (2001). Evidence of Helicobacter infection in the horse. In Proceedings of 101st General Meeting of the American Society for Microbiology. 20–24 May,Orlando, Florida, USA, 56.

Belli, C.B., Fernandes, W.R., & Silva, L.C. (2003). Positive urease test in adult horse with gastric ulcer-Helicobacter sp. Arquivos do Instituto Biologico, Instituto Biologico Avenida Conselheiro Rodrigues Alves. 70, 17–20.

Bezdekova, B., & Futas, J. (2009). Helicobacter species and gastric ulceration in horses: a clinical study. Veterinarni Medicina. 54(12), 577–582. http://vri.cz/docs/vetmed/54-12-577.pdf.

Hepburn, R.J. (2004). Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse. 1–137. http://hdl.handle.net/10919/33587.

Moyaert, H., Decostere, A., Vandamme, P., Debruyne, L., Mas,t J., Baele, M., Ceelen, L., Ducatelle, R., & Haesebrouck, F. (2007). Helicobacter equorum sp. Nov., a urease-negative Helicobacter species isolated from horses faeces. Int J Syst Evol Microbiol. 57, 213–218. doi: 10.1099/ijs.0.64279-0.

Moyaert, H., Haesebrouck, F., Dewulf, J., Ducatelle, R., & Pasmans, F. (2009). Helicobacter equorum is highly prevalent in foals. Vet Microbiol. 133(1–2), 190–192. doi: 10.1016/j.vetmic.2008.06.004.

Murray, M.J. (2005). Equine gastric ulcer syndrome (EGUS). In: Proceedings of 1st Scientific Symposium of European College of Equine Internal Medicine, 20–22 January. 82.

Niankovskyi, C.L., Ivakhenko, O.S. Tomkiv, Ya.M., Hudzan, N.F., & Ivantsiv, V.A. (2001). Try skladnyky zakhvoriuvan shlunkovo-kyshkovoho traktu u ditei: Refliuks – Helicobacter pylori. Lviv (in Ukrainian).

Luthersson, N., Nielsen, Hou K., Harris, P., & Parkin, T.D. (2009). Risk factors associated with equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet. J. 41(7), 625–630. https://www.ncbi.nlm.nih.gov/pubmed/19927579.

Murray, M. J., Schusser, G. F., Pipers, F.S., & Gross, S.J. (1996). Factors associated with gastric lesions in thoroughbred racehorses. Equine Vet. J. 28(5), 368–374. https://www.ncbi.nlm.nih.gov/pubmed/8894534.

Sandin, А. Skidell, J., Häggström, J., Girma, K., Nilsson, G. (1999). Post-mortem findings of gastric ulcers in Swedish horses up to 1 year of age: A retrospective study 1924–1996. Acta Vet. Scand. 40(2), 109–120. https://www.ncbi.nlm.nih.gov/pubmed/10605127.

Dukti, S.A., Perkins, S., Murphy, J., Barr, B., Boston, R., Southwood, L.L., & Bernard, W. (2006). Prevalence of gastric squamous ulceration in horses with abdominal pain. Equine Vet. J. 38(4), 347–349. https://www.ncbi.nlm.nih.gov/pubmed/16866203.

Murray, M.J., Grodinsky, C., Anderson, C.W., Radue, P.F., & Schmidt, G.R. (1989). Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine Vet. J. 7, 68–72. https://www.ncbi.nlm.nih.gov/pubmed/9118110.

Kubiak, K., Jankowski, M., Spużak, J., Niedźwiedź, A., Nicpoń, J., Vlizlo, V., & Maksymovych, I. (2010). Etiopathogenesis and diagnosis of gastric ulcers in horses. Bіologіja tvarin. 12(2), 291‒296. (іn Ukrainian).

Murray, M.J., Nout, Y.S., & Ward, D.L. (2001). Endoscopic findings of the gastric antrum and pylorus in horses: 162 cases (1996–2000). Journal of Veterinary Internal Medicine. 15(4), 401–406 https://www.ncbi.nlm.nih.gov/pubmed/11467600.

Andrews, F.M., Reinemeyer, C.R., Mccracken, M.D., Blackford, J.T., Nadeau, J.A., Saabye, L., Sötell, M., & Saxton, A. (2002). Comparison of endoscopic, necropsy and histology scoring of equine gastric ulcers. Equine Vet. J. 34(5), 475–478. https://www.ncbi.nlm.nih.gov/pubmed/12358050.

Macallister, C.G., Andrews, F.M., Deegan, E., Ruoff, W., & Olovson, S.G. (1997). A scoring system for equine gastric ulcers. Equine Vet. J. 29, 430–433.

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Published
2018-03-02
How to Cite
Stefanyk, O., & Slivinska, L. (2018). Equine gastric ulcer syndrome (EGUS). Prevalence, etiology, diagnostic. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 20(83), 156-161. https://doi.org/10.15421/nvlvet8330