Use of fluoroquinolones in practice of veterinary medicine of Ukraine


Keywords: fluoroquinolones, antibacterial agents, mechanism of action, bactericidal effect, generation, carencia, productive animals.

Abstract

Antibacterial agents are one of the most important groups of medical preparations  in the treatment of bacterial infection of different localization in humane and in veterinary medicine. The consequence of their rational use (the establishment of sensitivity of the pathogenic microflora, compliance with the course of treatment, etc.) have a high therapeutic effect and the minimum development of resistant strains of microorganisms. The widely used  group of antimicrobial agents in veterinary medicine are second-generation fluorohinolone antibiotics that have good pharmacokinetic properties, a broad spectrum of bactericidal activity, and relatively low toxicity, although they have their own warnings and restrictions on the use of small animals during the formation of bone tissue. To achieve high therapeutic efficacy and minimizing of side effects, it is described the compatibility of some fluoroquinolones with other pharmacological groups. They found their application in the treatment of both productive animals, poultry, fur animals and petty domestic (dogs and cats) with a bacterial infection of the urinary tract, digestive and respiratory systems, infected wounds, etc. The article describes the detailed mechanism of action of the antibiotics of the fluoroquinolone group, which provides an opportunity for a deeper understanding of the manifestation of the bactericidal effect, as well as their classification by generation or generation. Particular attention deserves attention to the time of carrenia of fluoroquinolones in the context of their application to productive animals, because high quality livestock products minimize the development of resistant strains in humans and provide them with health. There is also a list of all registered medicinal products registered in Ukraine containing: ofloxacin, enrofloxacin, ciprofloxacin, marbofloxacin, denofloxacin, which carries important informative information for practicing doctors, pharmacists, etc.

References

Albrecht, R. (1977). Development of antibacterial agents of the nalidixis acid type. Progress in Drug Research. 21, 9–104. https://link.springer.com/chapter/10.1007/978-3-0348-7098-6_1.

Asahiu, Y., & Ishizak, T. (1992). Recent advances in structure activity relationships in new quinolones. Progress in Drug Research. 38, 57–106. https://www.ncbi.nlm.nih.gov/pubmed/1609118.

Beco, L., Guaguere, E., Lorente Mendez, C., Noli, C., Nuttall, T., & Vroom, M. (2013). Suggested guidelines for using systemic antimicrobials in bacterial skin infections: part 2 – antimicrobial choice, treatment regimens and compliance. Veterinary Record. 172(6), 156–160. doi: 10.1136/vr.101070.

Blatun, L.A., Grishina, I.A., & Svetuhin, A.M. (1994). Primenenie novogo preparata iz gruppy ftorhinolonov – lomefloksacina (masavina) pri lechenii bol'nyh s ranevoj infekciej. Antibiotiki i himiote-rapija. 39(4), 37–39 (in Russian).

Bogomolov, N.S. (1995). Desjatiletnij opit primenenija ofloksacina v rekonstruktivnoj hirurgii. Ftorhinolony: sovremennoe znachenie v antibakterial'noj terapii, perspektiva razvitija. Bioinform, 17–19 (in Russian).

Brighty, K.E., & Gootz, T.D. (2000). Chemistry and Mechanism of Action of the Quinolone Antibacterials. The Quinolones 33–97. 10.1016/B978-012059517-4/50003-9.

Bush, V., Dal'hovej, A., & Cajler, H.J. (1993). Nastojashhee i budushhe hinolonov. Obzor literatury. Antibiotiki i himioterapija. 38(2–3), 3–8 (in Russian).

Cross, J.T. (2001). Fluoroquinolones. Seminars in Pediatric Infectious Diseases. 12(3), 211–223. 10.1053/spid.2001.24096.

Fadeeva, N.I., Shul'gina, M.V., & Glushkov, R.G. (1993). Molekuljarno-biologicheskie osobennosti antibakterial'nogo dejstvija proizvodnyh 4-hinolon-3-karbonovoj kisloty. Obzor. lit. Himiko-farmacevticheskij zhurn. 5, 5–19 (in Russian).

Khmelnytskyi, H.O., & Dukhnytskyi, V.B. (2017). Veterynarna farmakolohiia: pidruchnyk. Kyiv (in Ukrainian).

Kosenko, M.V., Muzyka, M.V., Pashkovska, O.Z., & Baloian, O.Z. (2000). Deiaki aspekty zastosuvannia ftorkhinoloniv v medychnii ta veterynarnii praktytsi. Nauk. Visn. Lvivskoi derzh. akad. veterynarnoi medytsyny im. S.Z. Hzhytskoho. 2(1), 90–92 (in Ukrainian).

Kotsiumbas, I.Ia. (2017). Veterynarni likarski zasoby Dovidnyk. Lviv: TzOV «VF» Afisha» (in Ukrainian).

Lode, H., Hoffken, G., Bolcke, M., Deppermann, N., Borner, K., & Koeppe, P. (1990). Quinolone pharmacokinetics and metabolism. Journal of Antimicrobial Chemotherapy. 26, 41–49. https://www.ncbi.nlm.nih.gov/pubmed/2124212.

Lode, H., Hoffken, G., Borner, K., & Koeppe, P. (1989). Unique aspects of quinolone pharmacokinetics. Clin. Pharmacokinetics. 16(1), 1–4. https://link.springer.com/ article/10.2165/00003088-198900161-00003.

Maslanka, T. (2014). Farmakologia kliniczna malych zwierzat. Olsztyn.

Padejskaja, E.N. (2000). Artrotoksichnost' kinolonov i ftorhinolonov v eksperimente: harakter porazhenij i vozmozhnyj mehanizm dejstvija. Antibiotiki i himioterapija. 45(8), 36–41 (in Russian).

Padejskaja, E.N., & Jakovlev, V.P. (1995). Ftorhinolony. M.: Bioinform (in Russian).

Padejskaja, E.N., & Jakovlev, V.P. (1996). Ofloksacin. Antibakterial'nyj preparat iz grup ftorhinolonov. M. (in Russian).

Piddock, L.J., Hall, M.C., & Wise, R. (1990). Mechanizm of action of lomefloxacin. Antimicrob Agents Chemother. 34(6), 1088–1093. https://www.ncbi.nlm. nih.gov/pmc/articles/PMC171763.

Slobodiuk, N.M. (2003). Vyznachennia toksychnosti ofloksatsynu pry sumisnomu zastosuvanni z dymeksydom. IV nauk. prakt. konf. Problemy neinfektsiinoi patolohii tvaryn. Bila Tserkva, 76–78 (in Ukrainian).

Smith, J.T. (1986). Mechanism of action of quinolones. Infection. 14(1), 3–15. https://www.ncbi.nlm.nih.gov/ pubmed/2420724.

Swarz, M.N. (1997). Use antimicrobial agents and drag resistance. The New England Journal of Medicine. 337, 491–492. doi: 10.1056/NEJM199708143370709.

Walker, R.C., & Wright, A.J. (1991). The fluoroquinolones. Mayo Clinic Proceedings. 66(12), 1249–1259. https://www.ncbi.nlm.nih.gov/pubmed/1749294.
Published
2018-04-26
How to Cite
Slobodyuk, N. (2018). Use of fluoroquinolones in practice of veterinary medicine of Ukraine. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 20(87), 89-93. https://doi.org/10.15421/nvlvet8718