Influence of cadmium loading on glutathione system of antioxidant protection of the bullocks’bodies


  • B. V. Gutyj Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine http://orcid.org/0000-0002-5971-8776
  • D. F. Gufriy Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine http://orcid.org/0000-0001-6425-7866
  • V. Y. Binkevych Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-2806-2452
  • R. O. Vasiv Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-0119-8704
  • N. V. Demus Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-0793-0484
  • K. Y. Leskiv Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0003-3763-3955
  • O. M. Binkevych Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine
  • O. V. Pavliv Separated subdivision of National University of Life and Environmental Sciences of Ukraine “Berezhany Agrotechnical Institute”, Berezhany, Ukraine https://orcid.org/0000-0003-1915-0642
Keywords: cadmium; superoxidedismutase, catalase, glutathione peroxidase; reduced glutathione, vitamins, selenium

Abstract

It was presented the results of studies of the cadmium effect loading on the activity of the glutathione system of antioxidant protection in young cattle, namely on the activity of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, the level of reduced glutathion. It was established that feeding of cadmium chloride to bullocks at a dose of 0.03 and 0.05 mg/kg body weight contributed to a decrease in both the enzyme and non-enzyme link of the glutathione antioxidant defense system. The toxic effect of cadmium contributes to a change in stationary concentrations of radical metabolites. О2˙ˉ, ˙ОН, НО2˙, which, in turn, initiate lipid peroxidation processes. The lowest level of glutathione indexes of the antioxidant defense system in the blood of young cattle was established on the sixteenth and twenty fourth day of the experiment, it was associated with enhanced activation of lipoperoxidation and an imbalance between the activity of the antioxidant system and the intensity of lipid peroxidation. The feeding of cadmium chloride to bullocks at a dose of 0.03 and 0.05 mg/kg of animal weight did not affect the activity of the glutathione antioxidant defense system in their blood. It was established that the greater the amount of cadmium chloride in the feed, the lower the activity of the glutathione system of the antioxidant defense of the body of bulls. Thus, cadmium chloride suppresses the antioxidant protection system, in particular, by reducing the activity of the enzyme link: glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and non-enzyme link: reduced glutathione.

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Published
2018-12-10
How to Cite
Gutyj, B., Gufriy, D., Binkevych, V., Vasiv, R., Demus, N., Leskiv, K., Binkevych, O., & Pavliv, O. (2018). Influence of cadmium loading on glutathione system of antioxidant protection of the bullocks’bodies. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 20(92), 34-40. https://doi.org/10.32718/nvlvet9207

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