Treatment of horses with asthma syndrome complicated myocardiodystrophy


Keywords: cardiopulmonary syndrome, equine asthma syndrome, myocardiodystrophy, comorbid pathology, bron-chodilators, metabolic therapy

Abstract

It has been established that in comorbid (cardiopulmonary) pathology in horses with asthma patients develop a syndrome of airway obstruction, morphofunctional changes in the erythrocyte system, impaired blood gas transmission function, increased permeability of cell membranes, which leads to complications in the form of myocardiodystrophy and cardiac failure. The use of a complex treatment regimen for horses with asthma and complicated myocardiodystrophy contributed to reducing attacks of respiratory dysfunction and symptoms of heart failure, reducing the incidence of arrhythmias and valvular regurgitation, reducing the number of neutrophils in the BAL washings, and reducing indicators characteristic of tissue hypoxia, (decrease in the number of erythrocytes, hemoglobin, hematocrit, mean corpuscular volume and mean corpuscular hemoglobin), elimination of the inflammatory process in the respiratory tract (decrease in the number of leukocytes, stab and segmented neutrophils), a decrease in the indices characterizing the integrity of the cardiomyocyte membranes (decrease in the activity of CК, CК-MB, LDH, LDH-1), restoration of diffuse capacity of the lungs (decrease in pH and increase in pO2 and pCO2 of blood). The mechanism of the positive effect of drugs that were used to treatment of horses with asthma syndrome with complicated myocardiodystrophy, which is achieved due to the cardio metabolic (cytoprotective) effect and antihypoxic ability to improve the diffusion of gases through the alveolar-capillary membrane, is established. On the one hand, it improves metabolic processes in the myocardium and, accordingly, reduces the manifestations of heart failure, and on the other hand, reduces hypoxia and respiratory failure (respiratory dysfunction), as one of the central pathogenetic mechanisms of cardiorespiratory comorbidity.

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References

Maksymovych, I., Siwińska, N., Słowikowska, M., Żak, A., & Niedźwiedź, A. (2016). Postać ciężka astmy koni – nowa nazwa znanej choroby. Weterynaria w terenie, 3, 74–79.

Sánchez, A., Couëtil, L.L., Ward, M.P., & Clark, S.P. (2005). Effect of airway disease on blood gas exchange in racehorses. Journal of Veterinary Internal Medicine, 19(1), 87–92. https://www.ncbi.nlm.nih. gov/pubmed/15715053.

Niedźwiedź, A., Nicpoń, J., & Różycki, P. (2006). Pathogenesis, diagnosis and treatment of Recurrent Equine Airway Obstruction. Med. Weter., 62(5), 512–515.

Pasławska, U., Nicpoń, J., & Noszczyk-Nowak, A. (2008). Wybrane metody klinicznej diagnostyki różnicowej przewlekłej niewydolności oddechowej u koni. Magazyn weterynaryjny, 17(2), 118–119.

Maksymovych, I.A. (2015). Retsydyvuiucha obstruktsiia dykhalnykh shliakhiv u konei: poshyrennia, etiolohiia ta patohenez. Naukovyi visnyk Lvivskoho natsionalnoho universytetu veterynarnoi medytsyny ta biotekhnolohii imeni S.Z. Gzhytskoho, 17, 2(62), 137–142. http://nbuv.gov.ua/UJRN/nvlnu_2015_17_2_31 (in Ukrainian).

Palomo, L., Rubio, C., & Gérvas, J. (2006). The comorbidity in primary care. Gac. Sanit., 20(1), 182–191. https://www.ncbi.nlm.nih.gov/pubmed/16539981.

Ollivier, R., Donal, E., Delaval, P., Daubert, J.C., & Mabo, P. (2007). Beta-blocker prescription and chronic obstructive pulmonary disease. Ann. Cardiol. Angeiol., 56(5), 231–236.

Falk, J.A., Kadiev, S., Criner, G.J., Scharf, S.M., Minai, O.A., & Diaz, P. (2008). Cardiac disease in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc., 5(4), 543–548. doi: 10.1513/pats.200708-142ET.

Avdeev, S.N., & Bajmakanova, G.E. (2008). HOBL i serdechno-sosudistye zabolevanija: mehanizmy associacii. Pul'monologija, 1, 5–13 (in Russian).

Ambrosino, N., & Simonds, A. (2007). The clinical management in extremely severe COPD. Respir. Med., 101(8), 1613–1624. doi: 10.1016/j.rmed.2007.02.011.

Korzh, A.N. (2008). Serdechno-sosudistaja patologija u bol'nyh hronicheskim obstruktivnym zabolevaniem legkih. Mezhdunarodnyj medicinskij zhurnal, 2, 41–46 (in Russian).

Chuchalin, A.G. (2008). Hronicheskoe obstruktivnoe zabolevanie legkih i soputstvujushhie zabolevanija. Ter. arhiv, 8, 45–50 (in Russian).

Maksymovych, I.A. (2017). Hematolohichnyi status konei za astmatychnoho syndromu. Nauk. visnyk veterynarnoi medytsyny, 1(133), 68–76 (in Ukrainian).

Chuchalin, A.G. (2008). Hronicheskoe obstruktivnoe zabolevanie legkih i soputstvujushhie zabolevanija. Zdorov’ja Ukrainy, 7, 37–39 (in Russian).

Capko, L.P., Afanas'ev, S.A., & Maksimov, I.V. (2016). Perspektivy metabolicheskoj terapii pri patologii serdca. Sibirskij medicinskij zhurnal, 31(4), 7–12. doi: 10.29001/2073-8552-2016-31-4-7-12 (in Rus-sian).

Duvivier, D.H., Bayly, W.M., Votion, D., Vandenput, S., Farnir, F., & Lekeux, P. (1999). Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD. Equine Vet. J., 31(1), 20–24. https://www.ncbi.nlm.nih.gov/pubmed/9952325.

Duvivier, D.H., Votion, D., Vandenput, S., Art, T., & Lekeux, P. (1997). Airway response of horses with COPD to dry powder inhalation of ipratropium bromide. Vet. J., 154(2), 149–153. https://www.ncbi.nlm.nih.gov/pubmed/9308401.

Robinson, N.E., Jackson, C., Jefcoat, A., Berney, C., Peroni, D., & Derksen, F.J. (2002). Efficacy of three corticosteroids for the treatment of recurrent airway obstruction (heaves). Equine Vet. J., 34(1), 17–22. https://www.ncbi.nlm.nih.gov/pubmed/11817547.

Amosova, E.N. (2000). Metabolicheskaja terapija povrezhdenija miokarda, obuslovlennogo ishemiej: novyj podhod k lecheniju ishemicheskoj bolezni serdca i serdechnoj nedostatochnosti. Ukr. kardiol. zhurn., 4, 85–92 (in Russian).

Schraeder, C., Dworak, D., Stoll, J.F., Kucera, C., Waldschmidt, V., & Dworak, M.P. (2005). Managing elders with comorbidities. J. Ambul. Care Manage, 28(3), 201–209. https://www.ncbi.nlm.nih.gov/ pubmed/15968212.

Sin, D.D., Anthonisen, N.R., Soriano, J.B., & Agusi, A.G. (2006). Mortality in COPD: role of comorbidities. Eur. Respir. J., 28(6), 1245–1257. doi: 10.1183/09031936.00133805.

Boudestein, L.C., Rutten, F.H., Cramer, M.J., Lammers, J.W., & Hoes, A.W. (2009). The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease. Eur. J. Heart Fail., 11(12), 1182–1188. doi: 10.1093/eurjhf/hfp148.

Ihnatenko, H.A., Mukhin, I.V., Faierman, A.O., Pola, M.K., Taktashov, H.S., Honcharov, O.M., Rybalko, H.S., & Volodkina, N.O. (2011). Vplyv Mildrokardu na morfofunktsionalnyi stan kardiorespiratornoi systemy u khvorykh na khronichnu sertsevu nedostatnist iz suputnim khronichnym obstruktyvnym zakhvoriuvanniam lehen. News of medicine and pharmacy, 13–14, 376–377 (in Ukrain-ian).

Gerber, V., Lindberg, A., Berney, C., Robinson, N.E. (2004). Airway mucus in recurrent airway obstruction–short-term response to environmental challenge. J Vet Intern Med., 18(1), 92–97. https://www.ncbi.nlm.nih.gov/pubmed/14765737.

Glazova, T.G., Ryvkin, A.I., & Pobedinskaja, N.S. (2012). Morfofunkcional'noe sostojanie jeritrocitov pri persistirujushhem techenii bronhial'noj astmy u detej. Pediatrija, 91(2), 19–23. https://pediatriajournal.ru/archive?show=321§ion=3365 (in Russian).

Nowak, W., Potkański, A., Zachwieja, A., Szulc, T., Wylegała, S., & Werwińska, K. (2005). Effect of herb extracts on serum immunoglobulins and calf-rearing results. Med Weter., 61, 1049–1054.

Pitchford, S.C., Riffo-Vasquez, Y., Sousa, A., Momi, S., Gresele, P., Spina, D., & Page, C.P. (2004). Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood, 103(2), 639–647. doi: 10.1182/blood-2003-05-1707.

Singh, T.P., Nigam, A.K., Gupta, A.K., & Singh, B. (2011). Cardiac Biomarkers: When to Test? – Physician Perspective. JIACM, 12(2), 117–121. http://medind.nic.in/jac/t11/i2/jact11i2p117.pdf.

Pasiieshvili, L.M., Zhelezniakova, N.M., & Pasiieshvili, T.M. (2015). Kliniko-patohenetychni osoblyvosti perebihu nealkoholnoi zhyrovoi khvoroby pechinky u khvorykh na bronkhialnu astmu ta ozhyrinnia. Hastroenterolohiia, 4, 47–52. http://nbuv.gov.ua/ UJRN/gastro_2015_4_9 (in Ukrainian).

Kratz, A., Lewandrowski, K.B., Siegel, A.J., Chun, K.Y., Flood, J.G., Van Cott, E.M., & Lee-Lewandrowski, E. (2002). Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers. Am. J. Clin. Pathol., 118(6), 856–863. doi: 10.1309/14TY-2TDJ-1X0Y-1V6V.

Tkach, S.M. (2008). Sistemnye podhody k diagnostike i lecheniju zhirovoj bolezni pecheni. Zdorovia Ukrainy, 22, 64–65 (in Russian).

Targher, G., Day, C., & Bonora, E. (2010). Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med., 363(14), 1341–1350. doi: 10.1056/NEJMra0912063.

Budnevskij, A.V. (2005). Sistemnyj podhod k izucheniju psihonejroimmunologicheskih vzaimodejstvij pri bronhial'noj astme. Sistemnyj analiz i upravlenie v biomedicinskih sistemah, 4(1), 20–23 (in Russian).

Budnevskij, A.V., Burlachuk, V.T., & Olysheva, N. (2010). Terapevticheskie podhody k kontrolju vospalenija na urovne melkih bronhov pri bronhial'-noj astme. Rossijskij allergologicheskij zhurnal, 4, 85–94 (in Russian).

Sysoeva, M.S., Solov'eva, A.V., Nikiforov, A.A., & Rakita, D.R. (2011). Vlijanie nalichija metabolicheskogo sindroma na klinicheskoe techenie bronhial'noj astmy. Rossijskij mediko-biologicheskij vestnik imeni akademika I.P. Pavlova, 4, 100–105 (in Russian).

Ermolova, A.V., & Budnevskij, A.V. (2013). Bronhial'-naja astma i metabolicheskij sindrom: vozmozhnosti dostizhenija kontrolja nad zabolevaniem i uluchshenija kachestva zhizni. Vrach-aspirant, 61(6.2), 319–325. http://vrach-aspirant.ru/articles/ pulmonology/13469/ (in Russian).

Tribunceva, L.V., Budnevskij, A.V., & Razvorotnev, A.V. (2012). Sistemnyj podhod k upravleniju terapiej bol'-nyh bronhial'noj astmoj. Vrach-aspirant, 1.2 (5), 338–342. http://vrach-aspirant.ru/articles/ pulmonology/12010/ (in Russian).

WHO (1996). Trace elements in human nutrition and healt. Geneva, XVIII. https://www.who.int/nutrition/ publications/micronutrients/9241561734/en.

Gavrisjuk, V.K. (2000). Narushenija serdechno-sosudistoj sistemy u bol'nyh bronhial'noj astmoj. Ukr. pul'mon. zhurn., 2, 31–32 (in Russian).

Aguilera-Tejero, E., Estepa, J.C., Lopez, I., Bas, S., Mayer-Valor, R., & Rodriguez, M. (2000). Quantitative analysis of acid-base balance in show jumpers before and after exercise. Res. Vet. Sci., 68(2), 103–108. doi: 10.1053/rvsc.1999.0341.

Effros, R.M., & Swenson, E.R. (2010). Acid_base bal-ance. Mason R.J. et al. Murray & Nadel’s Textbook of Respiratory Medicine. 5th ed. Philadelphia.

Maksymovych, I., Niedźwiedź, А., Leno, М., & Slivinskaya, L. (2017). Biochemical parameters and acid-base balanse of blood of horses with asthma syndrome. Scientific Messenger LNUVMB, 19(82), 205–211. https://nvlvet.com.ua/index.php/journal/ article/view/1367.

Nadtochij, E.V. (2015). Povrezhdajushhee vlijanie gipoksii na sostojanie mukociliarnogo apparata u bol'nyh bronhial'noj astmoj. Bjulleten' fiziologii i patologii dyhanija, 58, 30–33. https://elibrary.ru/item.asp?id=25013403 (in Russian).

Kornerup, K.N., & Page, C.P. (2007). The role of platelets in the pathophysiology of asthma. Platelets, 18(5), 319–328. doi: 10.1080/09537100701230436. https://www.ncbi.nlm.nih.gov/pubmed/17654302.

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Published
2018-12-10
How to Cite
Maksymovych, I., & Slivinska, L. (2018). Treatment of horses with asthma syndrome complicated myocardiodystrophy. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 20(92), 83-93. https://doi.org/10.32718/nvlvet9217