Pathomorphology of the cerebral cortex of cats for infectious peritonitis
The article presents the results of histological studies of the frontal area of the cerebral cortexб taken from 10 corpses of cats aged from 3 months to 5.5 years, in which infectious peritonitis (based on anamnesis, clinical signs, morphological and biochemical blood analysis , ultrasound diagnostics, Rivalt test and express diagnosis) was diagnosed during their life. A pathoanatomical study was conducted; samples of the frontal area of the cerebral cortex of cats, which were fixed in a 12% aqueous solution of neutral formalin, a solution of Carnoua and 96° ethyl alcohol, were selected. The histocuts were made, which were stained with hematoxylin and eosin, thionine for Nisslem. In order to detect the astrocytic glory, a fraction of the cerebral cortex was fixed by the Golgi-Clatzo method with a fresh mixture of chloral hydrate-formalin-bichromate and produced histocuts on a freezing microtome. For histological examination of the cerebral cortex of cats, changes in the non-inflammatory character were observed, which were characterized by disorders of hemomycrocycle circulation, edema and degenerative processes of the neuroglial complex and neurons. Violations of the structural organization of endothelial cells, basal membranes of capillaries and venules should be considered as an important indicator of functional changes in tone, permeability of the microcirculatory channel, which contributed to the development of perivascular and pericellular edema, which in its turn led to regressive changes of glial elements; acute swelling of neurons with the formation of microcavities in nuclei; a sharp decrease in the content of the chromatophilic substance in pyramidal and stellate cells; the development of gidropic dystrophy in star cells and creatures; rise of shadow cells. Circulatory disorders caused the violation of the trophic transport systems, which caused hypoxia, accumulation of acidic metabolism products, and formed the basis for the pathogenesis of the development of dyscirculatory dystrophy of neuroglial cells and neurons, i.e. neurotrophic disorders of the cerebral cortex of cats for FIR.
Baydar, E., Eröksüx, Y., & Timurkan, M.O. (2014). Feline infectious peritonitis with distinct ocular involvement in a cat in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 20(6), 961–965. doi: 10.9775/kvfd.2014.11195.
Diaz, J.V. & Poma, R. (2009). Diagnosis and clinical signs of feline infectious peritonitis in the central nervous system. The Canadian Veterinary Journal, 50 (10), 1091–1093. https://www.ncbi.nlm.nih.gov/pubmed/20046611.
Ermohin, P.N. (1969). Gistopatologija nervnoj sistemy. Moskva: Medicina (in Russian).
Filimonov, I.N. (1959). Anatomija i gistologija nervnoj sistemy. Moskva: “Medgiz” (in Russian).
Goral's'kyj, L.P., Homych, V.T., & Konons'kyj, O.I. (2005). Osnovy gistologichnoi' tehniky i mor-fofunkcional'ni metody doslidzhen' u normi ta pry patologii' [Bases of histological technology and mor-phofunctional methods of research in norm and in pa-thology]. Polissja, Zhytomyr (in Ukrainian).
Ives, E.J., Vanhaesebrouck, A.E. & Cian, F. (2013). Im-munocytochemical demonstration of feline infectious peritonitis virus within cerebrospinal fluid macrophag-es. Journal of Feline Medicine and Surgery, 15(12), 1149–1153. doi: 10.1177/1098612X13491960.
Kim, Y., Liu, H., Kankanamalage, A.C.G., Weerasekara, S., Hua, D.H., Groutas, W.C., Chang, K.-O., & Peder-sen, N.C. (2016). Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathogens, 12(3), e1005531. doi: 10.1371/journal.ppat.1005531.
Kotsiumbas, G., Pritsak, V., & Khalaniia, M. (2016). Patomorfolohichni zminy lehenevoi tkanyny za in-fektsiinoho perytonitu kotiv. Nauk. visnyk LNUVMB im. S.Z. Hzhytskoho, 3(70), 161–166 (in Ukrainian).
Majzelis, M.Ja. (1973). Gemato-jencefalicheskij bar'er i ego reguljacija. Moskva: Medicina (in Russian).
Merkulov, G.A. (1969). Kurs patologogystolohycheskoj tekhnyky [The course of pathohistological technique]. L.: Medycyna (in Russian).
Mesquita, L.P., Hora, A.S., Siqueira de A., Salvagni, F.A., Brandão, P.E. & Maiorka, P.C. (2016). Glial response in the central nervous system of cats with feline infectious peritonitis. Journal of Feline Medicine and Surgery, 18 (12), 1023–1030. doi: 10.1177/1098612X15615906.
Pedersen, N.C. (2014a). An update on feline infectious peritonitis: virology and immunopathogenesis. The Veterinary Journal, 201(2), 123–132. doi: 10.1016/j.tvjl.2014.04.017.
Pedersen, N.C. (2014b). An update on feline infectious peritonitis: Diagnostics and therapeutics. The Veterinary Journal, 201(2), 133–141. doi: 10.1016/j.tvjl.2014.04.016.
Pedersen, N.C., Liu, H., Dodd, K.A., & Pesavento, P.A. (2009). Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis. Viruses, 1(2), 166–184. doi: 10.3390/v1020166.
Pedersen, N.C., Liu, H., Durden, M., & Lyons, L.A. (2016). Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection. Veterinary Immunology and Immunopathology, 171, 17–20. doi: 10.1016/j.vetimm.2016.01.002.
Pedersen, N.C., Liu, H., Gandolfi, B., & Lyons, L.A. (2014). The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. Veterinary Immunology and Immunopathology, 162(1–2), 33–40. doi: 10.1016/j.vetimm.2014.09.001
Pyrs, Je. (1962). Gistohimyja. Moskva: Yzdatel'stvo inostrannoj lyteratury (in Russian).
Rissi, D.R. (2018). A retrospective study of the neuropathology and diagnosis of naturally occurring feline infectious peritonitis. Journal of Veterinary Diagnostic Investigation, 30(3), 392–399. doi: 10.1177/1040638718755833.
Skoromec, A.A., Skoromec, A.P., Skoromec, T.A. (2004). Topicheskaja diagnostika zabolevanij nervnoj sistemy. Sankt-Piterburg: Politehnika (in Russian).
Skrebkova, O.Ju. (2004). Ul'trastrukturna morfologіja aerogematichnogo bar’yera v umovah alkogol'noї іntoksikacіi v eksperymentі ta u ljudyny. Avtoreferat kand.med.nauk. Sіmferopol' (in Ukrainian).
Ziółkowska, N., Paździor-Czapula, K., Lewczuk, B., Mikulska-Skupień, E., Przybylska-Gornowicz, B., Kwiecińska, K., & Ziółkowski, H. (2017). Feline In-fectious Peritonitis: Immunohistochemical Features of Ocular Inflammation and the Distribution of Viral An-tigens in Structures of the Eye. Veterinary Pathology, 54(6), 933–944. doi: 10.1177/0300985817728557.
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