Pathomorphological changes in parenchymatose organs of rabbits in case of chronic passalurosis

Keywords: rabbits, passalurosis, histological changes, liver, kidneys, spleen


Pathomorphological changes, developing in case of pasalurosis chronic course in rabbits are described in the article. The research was held on ten rabbits of Large Grey breed, which were held on household farms of Poltava region. The diagnosing was complex: based on anamnesis data, clinical symptoms’ analysis, and the results of pathomorphological examination. The fragments of the liver, spleen, and kidneys were taken for histological analysis. While making histological analysis of the spleen it was revealed that lymphoid nodules were enlarged, some of them were of uniform structure, and others were in the state of hyperplasia. Non-uniformity of structure in addition to changing the size was registered in those nodules: there was less concentration of lymphoid cells in their central part and more concentration on the periphery. The situation was contrary in separate lymphoid nodules. The red pulp consisted of a large number of lymphoid cells and erythrocytes, the largest number of which were registered in the zones adjoining the places of lymphoid nodules’ location. Sometimes there were megakaryocytes in the field of vision. It was established, that blood filling of arteries was less than normal. In case of using some preparations, bilirubin inclusions were found at having big enlargements in red pulp. Grainy and fatty hepatocytes’ dystrophies, and also lymphohistiocytic interstitial hepatitis were also registered. At the same time, renal corpuscles were enlarged. Rather big spaces, filled with transparent substance containing vessel and cellular fragments (detritus), were revealed in the majority of them between glomeruli and the capsule.Capsule epithelial cells were destroyed in some places. Petechial hemorrhages were registered inside glomeruli. The destruction of separate podocytes and deep cells was noticed. The tubular epithelial cells were enlarged in size, and in some cases they were of cylinder, but not cubic shape; the spaces of such tubular were becoming correspondingly less. The epithelial cell cytoplasm of the tubular in some cases was not uniformand it was of cloudy-grey color: in other cases it had rather large colorless areas and, probably, looked like lipid inclusions (which were washed out from the cells as a result solvent impact during making histological preparations). Concentrations of eosinophilic masses (protein cylinders) sometimes containing certain amount of erythrocytes were often found in canaliculi spaces. Sometimes the destruction of epithelial cells was registered in the tubulеs, and their fragments were found in spaces. As a result of histological examination, the diffuse lymphohistiocytic infiltration in the renal interstitial tissue was found.


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Darzi, M.M., Mir, M.S., Kamil, S.A., Nashiruddullah, N., & Munshi, Z.H. (2007). Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus). World Rabbit Science, 15(1), 23–28. doi: 10.4995/wrs.2007.608.

Eira, C., Torres, J., Miquel, J., & Vingada, J. (2007). The helminth parasites of the wild rabbit Oryctolaguscu-niculus and their effect on host condition in Dunas de Mira, Portugal. Journal of Helminthology, 81(3), 239–246. doi: 10.1017/S0022149X07727426.

Elshahawy, І., & Elgoniemy, А. (2018). An Epidemiolog-ical Study on Endoparasites of Domestic Rabbits (Oryctolaguscuniculus) in Egypt with Special Refer-ence to Their Health Impact. Sains Malaysiana, 47(1), 9–18. doi: 10.17576/jsm-2018-4701-02.

Florian, D.D. (1997). Passaluroz krolikov v usloviyah Moskovskoy oblasti: Biologiya vozbuditelya, epizootologiya i meryi borbyi [Passalurosis of rabbits in the conditions of the Moscow region: Pathogen biology, epizootology and control measures]. Moscow (in Russian).

Goral's'kyj, L.P., Homych, V.T., & Konons'kyj, O.I. (2005). Osnovy gistologichnoi' tehniky i morfofunkcional'ni metody doslidzhen' u normi ta pry patologii' [Fundamentals of histological technique and morphofunctional methods of research in norm and pathology]. Polissja: Zhytomyr (in Ukrainian).

Kos'yanchuk, N.І. (2017). The rabbits myxomatosis prophylaxis Scientific Messenger LNUVMBT named after S. Z. Gzhytskyj, 19(73), 145–148. doi: 10.15421/nvlvet7330 (in Ukrainian).

Laakkonen, J., Nyyssönen, T., Hiltunen. M., Kauhala. K., Nikander, S., & Soveri T. (2006). Effects of Proto-strongylus sp. and Pneumocystis sp. on the pulmonary tissue and the condition of mountain and brown hares from Finland. Journal of Wildlife Diseases, 42(4), 780–787. doi: 10.7589/0090-3558-42.4.780.

Lello, J., Boag, B. & Hudson, P.J. (2005). The effect of single and concomitant pathogen infections on condi-tion and fecundity of the wild rabbit (Oryctolaguscu-niculus). International Journal of Parasitology, 35(4), 1509–1515. doi: 10.1016/j.ijpara.2005.06.002.

Motamedi, G., Moharami, M., Paykari, H., Eslampanah, M., & Omraninava, A. (2014). A. Survey on the Gas-trointestinal Parasites of Rabbit and Guinea Pig in a Laboratory Animal House. Archives of Razi Institute, 69(1), 77–81. doi: 10.7508/ari.2014.01.011.

Nagashyan, О.Z., & Tschеrbаkоv, О.V. (2005). Endoparasity i аssоciаtivnyi invаsii krоlikоv v Аrmеnii [Enodoparasites and associative invasions of rabbits in Armenia]. Vеtеrinarna mеdicinа: міzhvіd. теmаt. nаuk. zb. Kharkiv, 85(2), 809–810 (in Russian).

Okumu, P.O., Gathumbi, P.K., Karanja, D.N., Mande, J.D., Wanyoike, М.М., Gachuiri, С.К., Kiarie, N., Mwanza, R.N., & Borter, D.K. (2014). Prevalence, pa-thology and risk factors for coccidiosis in domestic rabbits (Oryctolagus cuniculus) in selected regions in Kenya. Veterinary Quarterly, 34(4), 205–210. doi: 10.1080/01652176.2014.978044.

Ola-Fadunsin, S.D., Hussain, K., Rabiu, M., & Ganiyu, I.А. (2018). Parasitic conditions of domestic owned rabbits in Osun State, southwestern Nigeria: Retro-spective evaluation, risk factors and co-infestations. International Journal of Veterinary Science and Medi-cine, 6(2), 208–212. doi: 10.1016/j.ijvsm.2018.06.002.

Rewatkar, S.G., Deshmukh, S.S., Kumar, P.G., Maske, D.K., & Bhangale, G.N. (2013). Occurrence of gastro-intestinal helminthes in rabbits with special reference to importance of Giardia spp. As parasitic zoonoses. Science, Technology and Arts Research Journal, 2(3), 142–143. doi: 10.4314/star.v2i3.98754.

Sharma, R., Kapoor, D., & Kumar, R. (2017). A rare case of verminous pneumonia in domestic rabbit. Journal of Parasitic Diseases, 41(3), 716–717. doi: 10.1007/s12639-016-0875-1.

Sürsal, N., Gökpinar, S., & Yildiz, K. (2014). Prevalence of intestinal parasites in hamsters and rabbits in some pet shops of Turkey. Turkiye Parazitol Derg, 38(2), 102–105. doi: 10.5152/tpd.2014.3338.

Szkucik, K., Pyz-Łukasik, R., Szczepaniak, K.O., & Paszkiewicz, W. (2014). Occurrence of gastrointestinal parasites in slaughter rabbits. Parasitol Res., 113(1), 59–64. doi: 10.1007/s00436-013-3625-7.

Zon, H.A., Skrypka, M.V., & Ivanivska, L.B. (2009). Patolohoanatomichnyi roztyn tvaryn [Pathogeanatomical section of animals]. Donetsk (in Ukrainian).

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Mykhailiutenko, S., Kruchynenko, O., Serdioucov, J., Klymenko, O., & Popovytch, J. (2019). Pathomorphological changes in parenchymatose organs of rabbits in case of chronic passalurosis. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(93), 31-36.