Therapeutic effectiveness of modern antihelminthic drugs for geese capillariasis
Many years of experience in fighting and preventing of helminthiasis in waterfowl shows that the successful elimination of parasitic diseases is possible under the conditions of a complex of organizational and economic, veterinary and sanitary and special anti-parasitic measures, which must necessarily include deworming of poultry. The purpose of the work was to study the effectiveness of modern antihelminthic drugs for the spontaneous capillariasis geese. Experimental testing of antihelminthic preparations of domestic production was performed: piperazine 45% (DR – piperazine adipinat), 22% phenzole (DR – fenbendazole) and brovadazole plus (DR – piperazine adipinat, phenbendazole). The efficacy of the drugs was determined by the results of helminthic autopsy and coproscopicof the geese of the experimental and control groups. The main indicators of the action of drugs were extensiveness and intensive. It was established that according to the results of helminthocoproscopic investigations, the most effective drugs for capillariasis geese were phenzole 22% and brovadazole plus, their effectiveness at day 15 of the experiment was 100.0%. Efficiency (EE and IE) of piperazine 45% was slightly lower and at day 5 of treatment, according to the results of the coproscopy, was 40.0% and 65.0% respectively, for 10 days – 70.0% and 76.0%, for 15 days – 70% , 0 and 82.0%. At the same time, according to the results of helminthic autopsy geese in the process of their treatment, the effectiveness of the preparations of phenzole 22% and piperazine 45% were lower. EI of experimental geese for 15 days with the use of phenzole 22% was 40.0%, and II decreased from 21.20 ± 1.16 to 2.00 ± 1.00 ex./head. In the application of piperazine, 45% of the experimental poultry EI for 15 days reached 60.0%, II decreased from 22.40 ± 1.12 to 3.67 ± 0.58 ex./head. Extens- and intensefficiency of piperazine 45% was 40.0 and 86.0%, phenzole 22% – 60.0 and 92.0%, respectively. It was determined that the most effective preparation for geese capillariasis is brovadazole plus (EE, IE – 100.0%), which is confirmed by the results of coproscopic studies and helminthic autopsy. Based on the data obtained, confirmed by experimental studies, we recommend the use of the drug brovadazol plus in the control and prevention of capillariasis geese.
Alaijos, O.R., & Javier, R.F. (2015). The Antihelminthic Efficacy of Artemisia Capillaris in Free-Range Chick-ens Naturally Infected with Ascaridia Galli, Capillar-ia Spp and Strongyloides Spp. International Journal of Life Sciences Research, 3(3), 20–22.
Bellaw, J.L., Krebs, K., Reinemeyer, C.R., Norris, J.K., Scare, J.A., Pagano, S., & Nielsen, M.K. (2018). Anthelmintic therapy of equine cyathostomin nematodes-larvicidal efficacy, egg reappearance period, and drug resistance. International Journal for Parasitology, 48(2), 97–105. doi: 10.1016/ j.ijpara.2017.08.009.
Condi, G., Soutello, R., & Amarante, A. (2009). Moxidectin-resistant nematodes in cattle in Brazil. Veterinary Parasitology, 161(3–4), 213–217. doi: 10.1016/j.vetpar.2009.01.031.
Enigr, K. (1975). Die Behandiung des Hausgefluges. Tierarztl Umsch, 30(7), 324–329.
Gartrell, B.D., Alley, M.R., & Mitchell, A.H. (2005). Fatal levamisole toxicosis of captive kiwi (Apteryx mantelli). New Zealand Veterinary Journal, 53(1), 84–86. doi: 10.1080/00480169.2005.36474.
Ibarra-Velarde, F., Guerrero-Molina, С., Vera-Montenegro, Y., Alcalá-Canto, Y., & Romero-Callejas, Е. (2011). Comparison of the anthelmintic efficacy of three commercial products against ascarids and capillaria spp. in fighting cocks. Journal of Pharmacy and Pharmacology, 2(3), 146–150. doi: 10.4236/pp.2011.23020.
Islam, A., Anisuzzaman, Majumder, S., Islam, M.A., Rabbi, A.K.M.A., & Rahman, M.H. (2012). Efficacy of anthelmintics against nematodes in naturally infected free range ducks. Eurasian Journal of Veterinary Sciences, 28(4), 229–232. http://eurasianjvetsci.org/pdf/pdf_EJVS_976.pdf.
James, C.E., Hudson, A.L., & Davey, M.W. (2009). Drug resistance mechanisms in helminths: is it survival of the fittest? Trends in Parasitology, 25(7), 328–335. doi: 10.1016/j.pt.2009.04.004.
Javid, A., Syed, T. & Bilal, A.Z. (2013) In vitro anthelmintic activity of Mentha longifolia (L.) leaves against Ascaridia galli. Global Veterinaria, 11(1), 112–117. doi: 10.1017/S0043933915002615.
Kazachkova, R.V. (2003). Gelmintofauna vodoplavajushhih ptic Brjanskoj oblasti i mery borby s osnovnymi gelmіntozami (Diss. kand. vet. nauk). Moskva (in Russian).
Kovalenko, I.I. (1985). Panakur kur i gusej. Veterinarija, 8, 42–43 (in Russian).
Mwamachi, D.M., Audho, J.O., Thorpe, W., & Baker, R.L. (1995). Evidence for multiple anthelmintic resistance in sheep and goats reared under the same management in coastal Kenya. Veterinary Parasitology, 60(3-4), 303–313. doi: 10.1016/0304-4017(95)00794-1.
Natjagla, I.V. (2016). Likuvalna efektyvnist antygelmintnyh preparativ za kapiljariozu kurej. Naukovo-tehnichnyj bjuleten' NDC biobezpeky ta ekologichnogo kontrolju resursiv APK, 4(3), 65–68. Retrieved from http://www.biosafety-center.dp.ua (in Ukrainian).
Pena-Espinoza, M. (2018). Drug resistance in parasitic helminths of veterinary importance in Chile: Status review and research needs. Austral Journal of Veterinary Sciences, 50(2), 65–76. doi: 10.4067/S0719-81322018000200065.
Pulaski, C.N., Malone, J.B., Bourguinat, C., Prichard, R., Geary, T., Ward, D., Klei, T. R., Guidry, T., Smith, G., Delcambre, B., Bova, J., Pepping, J., Carmichael, J., Schenker, R., & Pariaut, R. (2014). Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs. Parasites and Vectors, 7, 494. doi: 10.1186/s13071-014-0494-6.
Raza, A., Muhammad, F., Bashir, S., & Aslam, B. (2016). In-vitro and in-vivo anthelmintic potential of different medicinal plants against Ascaridia galli infection in poultry birds. World's Poultry Science Journal, 72(1), 115–124. doi: 10.1017/S0043933915002615.
Redman, E., Whitelaw, F., Tait, A., Burgess, C., Bartley, Y., Skuce, P.J., Jackson, F., & Gilleard, J.S. (2015). The emergence of resistance to the benzimidazole anthlemintics in parasitic nematodes of livestock is characterised by multiple independent hard and soft selective sweeps. PLOS Neglected Tropical Diseases, 9(2), e0003494. doi: 10.1371/journal.pntd.0003494.
Sharma, R.L., Bhat, T.K., & Hemaprasanth (1990). Anthelmintic activity of ivermectin against experimental Ascaridia galli infection in chickens. Veterinary Parasitology, 37(3-4), 307–314. doi: 10.1016/0304-4017(90)90014-3.
Shevcov, A.A. (1967). Opyt ozdorovlenija pticy ot gelmintozov. Veterinarija, 5, 81–82 (in Russian).
Shumard, R.F. (1957). The Toxicity to Chickens and the Anthelmintic Effect of Two Forms of a Piperazine-Carbon Disulfide Complex on Ascaridia galli and Heterakis gallinae. Poultry Science, 36(3), 613–618. doi: 10.3382/ps.0360613.
Skrjabin, K.I. (1928). Metod polnyh gel'mintologicheskih vskrytij pozvonochnyh, vkljuchaja cheloveka. Moskva (in Russian).
Squires, S., Fisher, M., Gladstone, O., Rogerson, S., Martin, P., Martin, S., Lester, H., Sygall, R., & Underwood, N. (2012). Comparative efficacy of flubendazole and a commercially available herbal wormer against natural infections of Ascaridia galli, Heterakis gallinarum and intestinal Capillaria spp. in chickens. Veterinary Parasitology, 185(2-4), 352–354. doi: 10.1016/j.vetpar.2011.09.034.
Taylor, S.M., Kenny, J., Houston, A., & Hewitt, S.A. (1993). Efficacy, pharmacokinetics and effects on egg-laying and hatchability of two dose rates of in-feed fenbendazole for the treatment of Capillaria species infections in chickens. Veterinary Record, 133(21), 519–521. doi: 10.1136/vr.133.21.519.
Trach, V.N. (1992). Rekomendacii po primeneniju novogo metoda ucheta jaic gelmintov i cist prostejshih v fekalijah zhivotnyh. Kiev (in Russian).
Tucker, C.A., Yazwinski, T.A., Reynolds, L., Johnson, Z., & Keating, M. (2007). Determination of the anthel-mintic efficacy of albendazole in the treatment of chicken naturally infected with gastrointestinal hel-minthes. Journal of Applied Poultry Research, 16(3), 392–396. doi: 10.1093/japr/16.3.392.
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