Pathogenetic aspects of dogs’ infectious hepatitis treatment
The article presents the mechanisms of development and dynamics of changes in the treatment of dogs’ infectious hepatitis. According to reports from doctors of veterinary medicine in clinics of small animals of Zhytomyr, the following infectious diseases are dominated in dogs: parvovirus enteritis, viral hepatitis, parainfluenic dogs, leptospirosis, carnivorous plague, trichophytosis and food toxicoinfection. One of the most common diseases in clinical practice was infectious hepatitis, which became the object of our research. The study of various aspects of the liver function pathology in diseases of viral etiology is especially relevant because of the exclusive compensatory potentials of this organ, their clinical manifestation is often found in the stage of severe morphofunctional violations, often not subject to reverse development. The purpose of our work was to study the influence Adenovirus саnіnе – a pathogen of dogs’ infectious hepatitis, on the functional state of the liver, to find out the effectiveness of the drug hepato-lik in the complex intensive care of sick dogs. The subject of the study were patients with infectious dogs’ hepatitis. The main diagnostic criterion was the use of express texts, which confirmed the previous diagnosis – infectious dogs’ hepatitis. For the study of the effectiveness of the used treatment of infectious hepatitis, an experimental animal was developed on the organism of the dogs – from 10 patients and control – out of 10 healthy. The applied treatment for infectious dogs’ hepatitis was comprehensive, and included silence, calmness and diet therapy. In order to restore the functional status of the dogs’ liver with hepatitis, the treatment regimen included 5% glucose solution with 5% solution of ascorbic acid in a dose, 40% solution of glutargin and 2% solution of riboxin for 5–10 days. Assigned vitamin preparation hepavicle and used symptomatic therapy. For the normalization of the function and regeneration of the liver after the action of adenovirus, as well as to reduce the negative effects of drugs having hepatotoxic action used hepato-lik. In order to assess the efficacy of the treatment, animals were examined clinically and blood samples were taken for the conduct of studies on the 10th and 30th day of treatment. The scheme of treatment for infectious dogs’ hepatitis using hepatoprotector hepatolique has been used to improve the functional state of the liver, which was manifested in the restoration of the white-oxidative, pigmentary, anti-toxic function, improvement of detoxification function, the suppression of liver inflammation, and also contributed to the preservation and restoration of the structure of hepatocytes, normalization of ammonia levels in the dog's organism, accelerated the regeneration of the liver cells, and had little positive effect on erythrocytopoies and on the general condition of the orgnism in general.
Cherkashina, M.A., Gorjacheva, M.A., & Dorofeeva, V.P. (2016). Patologija pecheni u sobak. Nauchnyj al'manah, 12(2), 382–385. https://elibrary.ru/ item.asp?id=28387708 (in Russian).
Dmytrenko, N.I., & Mizin, A.V. (2014). Osoblyvosti kliniko-morfolohichnoho proiavu virusnoho hepatytu sobak. Visnyk Sumskoho natsionalnoho ahrarnoho universytetu: Veterynarna medytsyna, 1(34), 104–106. http://nbuv.gov.ua/UJRN/Vsna_vet_2014_1_31 (in Ukrainian).
Jin, H., Xu, Y., Shi, F., & Hu, S. (2019). Vaccination at different anatomic sites induces different levels of the immune responses. Research in veterinary science, 122, 50–55. doi: 10.1016/j.rvsc.2018.11.005.
Kapoor, A., Simmonds, P., Gerold, G., et al. (2011). Char-acterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci USA. 108, 11608–11613. doi: 10.1073/pnas.1101794108.
Kearns, S. (2009). Infectious hepatopathies in dogs and cats. Top Companion Anim Med., 24(4), 189–198. doi: 10.1053/j.tcam.2009.06.004.
Lai, M., & Liaw, Y.F. (2010). Chronic hepatitis B: past, present, and future. Clin Liver Dis., 14(3), 531–546. doi: 10.1016/j.cld.2010.05.003.
Longhi, M.S., Hussain, M.J., Bogdanos, D.P., et al. (2007). Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hep-atitis type 2. Hepatology. 46(2), 472–484. doi: 10.1002/hep.21658.
Marcellin, P. (2009). Hepatitis B and hepatitis C in 2009. Liver Int., 29(1), 1–8. doi: 10.1111/j.1478-3231.2008.01947.x.
Morozenko, D.V., & Tymoshenko, O.P. (2012). Bio-khimichni pokaznyky stanu spoluchnoi tkanyny u pato-henezi, diahnostytsi ta kontroli efektyvnosti likuvannia hepatopatii sobak. Biolohiia tvaryn, 14(1–2), 411–419 http://nbuv.gov.ua/UJRN/bitv_2012_14_1-2_67 (in Ukrainian).
Nimand, H.G., & Suter, P.F. (2008). Prakticheskoe rukovodstvo dlja veterinarnyh vrachej (organizacija veterinarnoj kliniki, obsledovanie, diagnostika zabolevanij, lechenie). M.: Akvarium-print (in Russian).
Poldervaart, J.H., Favier, R.P., Penning, L.C., et al. (2009). Primary hepatitis in dogs: a retrospective review (2002–2006). J Vet Intern Med. 23(1), 72–80. doi: 10.1111/j.1939-1676.2008.0215.x.
Rakich, P.M., Prasse, K.W., Lukert, P.D. et al. (1986). Immunohistochemical detection of canine adenovirus in paraffin sections of liver. Vet Pathol. 23(4), 478–484. doi: 10.1177/030098588602300419.
Rodionov, V.D., Vatnikov, Ju.A., & Vilkovyskij, I.F. (2018). Diagnostika jeritrocitarnyh narushenij pri ostrom gepatite u sobak. Teoreticheskie i prikladnye problemy agropromyshlennogo kompleksa, 2(35), 22–27 (in Russian).
Sawhney, R., & Visvanathan, K. (2011). Polymorphisms of toll-like receptors and their pathways in viral hepa-titis. Antivir Ther, 16, 443–458. doi: 10.3851/IMP1820.
Speeti, M. (2014). Doberman hepatitis: comparison of subclinical and clinical stages and evaluation of eti-opathogenesis of the disease. Helsinki: Department of Bacteriology and Immunology Haartman Institute, University of Helsinki.
Vahrusheva, T.I. (2015). Patomorfologicheskie izmeneni-ja pri infekcionnom gepatite u sobak. Vestnik Kras-nojarskogo gosudarstvennogo agrarnogo universiteta, 2, 33–38. https://cyberleninka.ru/article/n/ patomorfologicheskie-izmeneniya-pri-infektsionnom-gepatite-u-sobak (in Russian).
Vergani, D., Longhi, M.S., Bogdanos, D.P. et al. (2009). Autoimmune hepatitis. Semin Immunopathol. 31(3), 421–435. doi: 10.1007/s00281-009-0170-7.
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