The research of tolerance of solution for intrauterus application “Yodozol”


  • R. M. Sachuk Research Epizootology Station IVM NAAS, Rivne, Ukraine https://orcid.org/0000-0003-4532-4220
  • O. A. Katsaraba Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0001-8520-224X
  • Ya. S. Stravsky DVNZ “Ternopil State Medical University named after I. Ya. Gorbachevsky of the Ministry of Health of Ukraine”, Ternopil, Ukraine
  • S. V. Zhigalyuk Research Epizootology Station IVM NAAS, Rivne, Ukraine
Keywords: iodine, potassium iodide, dose, blood, hematology, biochemistry, calving, service period, “Yodozol”

Abstract

Complex clinical trials have been carried out in order to study the tolerance and detail of the effect on the morpho-functional state of the organism of target animals of the new development of PE “Biopharm” and the Experimental Station of Epizootology IVM NAAS – solution for intrauterus use in the form of aerosol “Yodozol”, which will help predict the appearance of side effects from drug and prevent it. Methods of evaluation of a medicinal product for clinical trials, including for determining tolerance limits, which were used, included: the determination of the general clinical state of the organism, the study of hematological and biochemical parameters of blood, the control of the age of their first calving and service period, as well as statistical (calculation of average values and error of experimental data). “Yodozol” is a light yellow liquid, 1 ml of which contains 5 mg of iodine and 10 mg of potassium iodide. The drug is used for the prophylaxis and treatment of postpartum intrauterine infections in cows, pigs, sheep and goats (endometritis, pyrometers, cervicitis, vaginitis, delayed digestion caused by microorganisms sensitive to iodine), after giving rhombus, cesarean section and postpartum sanitation of the uterus. Medical product possesses antimicrobial, anti-inflammatory and analgesic actions, improves proliferative processes of genital organs, reduces the time of recovery of animals. The drug is used in accordance with the guidelines, after which livestock products are used without restriction. It has been established that the new medicinal product “Yodozol” with three times intrauterine application of cattle at intervals of 48 hours in doses that 2–10 times exceeds the recommended therapeutic, is tolerant. The excess amount of the drug does not cause significant side effects when injected into the uterus. There was no negative influence on the general clinical condition of cows and changes in the morpho-functional state of their organism. Three animals had an increase in the volume of the uterus, omission of horns and the body of the uterus. However, this is a normal individual physiological local reaction of the body to the introduction of an increased amount of foreign matter, which does not affect the general physiological state of animals. The volume and physiological placement of the uterus independently came to normal after the discontinuation of the drug. In all experimental animals exposed to different doses of the iodosol drug, the age of their first calving was from 29.0 ± 1.87 to 33.7 ± 2.27 months, the service period from 76.3 ± 2.27 to 81.0 ± 0.71 days, fluctuating within the limits of physiological norms. All conducted studies of the tolerance of the solution for intrauterine application “Yodozol” were included in the registration materials of the medicinal product.

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References

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Published
2019-07-30
How to Cite
Sachuk, R., Katsaraba, O., Stravsky, Y., & Zhigalyuk, S. (2019). The research of tolerance of solution for intrauterus application “Yodozol”. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(94), 15-19. https://doi.org/10.32718/nvlvet9403