The selection of the concentration of clotrimazole and povidone-iodineas the main active substances of the “Micromar” antifungal agent


Keywords: cat, microsporium, clotrimazole, povidone iodine, culture of fungus Microsporum sannis, “DERMAKIT” environment, Saburo agar, blood agar, Muller-Hinton agar

Abstract

Microsporia is one of the most common skin diseases of cats, most often provoked by the pathogen Microsporum canis. The pathogen of microsporium has highly contagious properties and for a long time remains capable of infection in the environment.  It is important for the veterinary doctor not only to carry out complex therapy, but also to prevent the spread of the pathogen in the environment and to prevent the occurrence of secondary pyoderma during the course of microspores. Due to the tendency to the growth of fungal diseases, the development of the pathogen’s resistance existing medicines, there is a need for effective antifungal medicines that have fungicide and fungicidal effect. The development of the antifungal agent “Micromar” will allow to carry out complex treatments for the treatment of microspores in cats. Also, thanks to the properties of basic active ingredient? Th use of “Micromar” will provide acceleration of recovery period.  The combination of clotrimazole and povidone iodine will provide an effective antifungal action with an antiseptic effect. Clotrimazole is a broad-spectrum antifungal agent that does not cause pathogen resistance. In turn, povidone iodine will provide antiseptic protection to the affected area of the cat's body with a prolonged effect. The studies were conducted to determine the concentration of clotrimazole and povidone iodine as the main active substances of the antifungal agent “Micromar” in the laboratory in nutrient media during the cultivation of the fungus Microsporum sanis. The results of the studies showed that the pure culture of the pathogen is sensitive to clotrimazole at a concentration of 0.25% and iodine povidone 5%. In appropriate concentrations, it is recommended to use clotrimazole and povidone iodine for the manufacture of the antifungal agent Micromar.

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Published
2019-11-02
How to Cite
Kisera, I., & Martyniv, Y. (2019). The selection of the concentration of clotrimazole and povidone-iodineas the main active substances of the “Micromar” antifungal agent. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(95), 27-31. https://doi.org/10.32718/nvlvet9505