The selection of the concentration of clotrimazole and povidone-iodineas the main active substances of the “Micromar” antifungal agent

Keywords: cat, microsporium, clotrimazole, povidone iodine, culture of fungus Microsporum sannis, “DERMAKIT” environment, Saburo agar, blood agar, Muller-Hinton agar


Microsporia is one of the most common skin diseases of cats, most often provoked by the pathogen Microsporum canis. The pathogen of microsporium has highly contagious properties and for a long time remains capable of infection in the environment.  It is important for the veterinary doctor not only to carry out complex therapy, but also to prevent the spread of the pathogen in the environment and to prevent the occurrence of secondary pyoderma during the course of microspores. Due to the tendency to the growth of fungal diseases, the development of the pathogen’s resistance existing medicines, there is a need for effective antifungal medicines that have fungicide and fungicidal effect. The development of the antifungal agent “Micromar” will allow to carry out complex treatments for the treatment of microspores in cats. Also, thanks to the properties of basic active ingredient? Th use of “Micromar” will provide acceleration of recovery period.  The combination of clotrimazole and povidone iodine will provide an effective antifungal action with an antiseptic effect. Clotrimazole is a broad-spectrum antifungal agent that does not cause pathogen resistance. In turn, povidone iodine will provide antiseptic protection to the affected area of the cat's body with a prolonged effect. The studies were conducted to determine the concentration of clotrimazole and povidone iodine as the main active substances of the antifungal agent “Micromar” in the laboratory in nutrient media during the cultivation of the fungus Microsporum sanis. The results of the studies showed that the pure culture of the pathogen is sensitive to clotrimazole at a concentration of 0.25% and iodine povidone 5%. In appropriate concentrations, it is recommended to use clotrimazole and povidone iodine for the manufacture of the antifungal agent Micromar.


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Budumjan, T.M., & Panova, E.O. (2003). Jetiologija i lechenie zooantropoznoj mikrosporii. Rossijskij zhurnal kozhnyh i venericheskih boleznej, 6, 33–35 (in Russian).

Cafarchia, C., Romito, D., Capelli, G., Guillot, J., & Otranto, D. (2006). Isolation of Microsporum canis from the hair coat of pet dogs and cats belonging to owners diagnosed with M. canis tinea corporis. Vet. Dermatol, 17, 327–331. doi: 10.1111/j.1365-3164.2006.00533.x.

Jaremchuk, A.A., Polovko, N.P., & Strilec, O.P. (2010). Sravnitel'noe izuchenie protivogribkovoj aktivnosti lekarst-vennyh sredst. Zhurnal Vestnik farmacii. Iz-datel'stvo: Vitebskij gosudarstvennyj medicinskij uni-versitet (Vitebsk), 56–60 (in Russian).

Klimko, N.N. (2007). Mikozy: diagnostika i lechenie: Rukovodstvo dlja vrachej. M.: Prem'er MT (in Russian).

Kovalenko, V.N., & Viktorova, A.P. (2011). Kompendium 2011 – Lekarstvennye preparaty. K.: Morion (in Russian).

Krylov, Ju.F. (2001). Jenciklopedija lekarstv. M. (in Russian).

Mancianti, F., Nardoni, S., Corazza, M., D’achille, P., & Ponticelli, C. (2003). Environmental detection of Microsporum canis arthrospores in the households of infected cats and dogs. J. Feline Med. Surg., 5, 323–328. doi: 10.1016/S1098-612X(03)00071-8.

Ramsey, I. (2007). Small animal formulary. BSAVA. 6th edition. Reprinted with corrections.

Ruppel', V.V. (2018). Dermatofitija. Kak diagnostirovat' i lechit' v uslovijah veterinarnoj kliniki. Veterinarnyj Pe-terburg, 2. (in Russian).

Sparkes, A.H., Robinson, A., MacKay, A.D., & Shaw, S.E. (2000). A study of the efficacy of topical and systemic therapy for the treatment of feline Microsporum canis infection. J. Feline Med. Surg., 2, 135–142. doi: 10.1053/jfms.2000.0093.

Sparkes, A.H., Werrett, G., Stokes, C.R., & Gruffydd-Jones, T.J. (1994). Microsporum canis: Inapparent carriage by cats and the viability of arthrospores. J. Small Anim. Pract., 35, 397–401. doi: 10.1111/j.1748-5827.1994.tb03861.x.

Taplin, D., Zaias, N., Rebell, G., & Blank, H. (1969). Isolation and recognition of dermatophytes on a new medium (DTM). Arch Dermatol., 99(2), 203–209.

TU U 24.4-37219230-001:2011 (2011). Metod pryhotu-vannia aharu Miullera-Khintona dlia funhitsydiv (in Ukrainian).

TU U 37 219230-001 2011 (2011). Metod pryhotuvannia krovianoho aharu (in Ukrainian).

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How to Cite
Kisera, I., & Martyniv, Y. (2019). The selection of the concentration of clotrimazole and povidone-iodineas the main active substances of the “Micromar” antifungal agent. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(95), 27-31.