Some indices of the cats’ protein metabolism under the obesity


Keywords: cat, obesity, blood, ammonia, urine, proteins, sulfhydryl groups

Abstract

Obesity is one of the most widely-distributed metabolic disturbances in cats, herewith the animals’ number with a given pathology is constantly increasing. The excess mass and obesity lead to the extreme metabolic disturbances including all the chains of metabolism. The cats belong to wild animals and are characterized by a high level of protein metabolism, herewith they are incapable to keep up with the level of the particular amino acids under their constant introduction into the feeds. The intensity of glucogenesis for which the amino acids are viscous material and are involved into the process of dissemination under the obesity is constantly increasing. It results in increasing the amount of final product of nitrogen metabolism. The paper researches the total protein content as well as that of albumin, ammonia, urine, creatinine and creatine kinase activity of the cats’ blood which had the excess mass or obesity. In addition, it has become necessary to determine the content of amino acids cysteine sulfhydryl groups, which essentially contributes to the process of cats’ metabolism. To perform the research two groups of cats (female and male) aged 37 were formed, the control group consists of 7 clinically healthy animals that corresponds to the BCS 45 index according to the nine grading scale, the experimental group consists of 5 animals of the same age and they have BCS 79 index, that testifies to the excess mass and obesity processes. The concentration of the total protein, albumin, ammonia, urine, creatinine as well as of creatine kinase activity of the total and free(nonprotein) sulfhydryl groups was found in the cats’ blood. The significant decreasing of the albumin part has been revealed in cats with the excess mass and obesity that causes the liver function disturbances and results in increasing of its protein decomposition. The increasing quality of the ammonia content by 31% and urine by 21% has been revealed in cats of the experimental group, however the individual ranges of given indexes within both control and experimental groups were considerable ones. The creatinine concentration and creatine kinase activity in cats with the obesity increases, that testifies to the destructive processes intensification in the muscular tissues. Sulfhydryl groups of the cysteine are of great importance for the metabolic processes in particular in the processes of detoxication, disease-resistance as well as of antioxidant processes. The total concentration of SH-blood groups made no essential difference in cats of the control and experimental groups, while the concentration of free SH-blood groups of experimental animals was by 31% less than in its control analogues. Thus, the obesity has an essential effects on the protein metabolism that causes the amino acids decomposition processes as well as the accumulation of the metabolic final products and free sulfhydryl groups reducing.

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References

Backlund, B., Zoran, D.L., Nabity, M.B., Norby, B., & Bauer, J.E. (2011). Effects of Dietary Protein Content on Renal Parametrs in Normal Cats. Journal of Feline Medicine & Surgery, 13, 698–704. doi: 10.1016/jfms2011.05.019.

Chala, I.V., Zghozinska, O.A., Rusak, V.S., Chuprun, L.O., & Kovalov, P.V. (2018). Zminy stanu hluta-tionovoi systemy krovi kotiv za tsukrovoho diabetu ta ozhyrinnia. Naukovyj visnyk LNUVMB imeni S.Z. G'zhyc'kogo. Serija: Veterynarni nauky, 20(88), 125−130. doi: 10.32718/nvlvet8823 (in Ukrainian).

Dor, C., Adamany, J.L., Kisielewicz, C., de Brot, S., Erles, K., & Dhumaeux, M.P. (2018). Acquired Urea Cycle Amino Acid Deficiency and Hyperammonaemic En-cephalopathy in a Cat with Inflammatory Bowel Dis-ease and Chronic Kidney Disease. Journal of Feline Medicine & Surgery. Open Reports, 4(2). doi: 10.1177/2055116918786750.

Flanagan, J., Bissot, T., Hours, M.A., Moreno, B., & Ger-man, A.J. (2018). An International Multi-Centre Study of Weight Loss in Overweight Cats: Differences in Outcome in Different Geographical Locations. Journal PLoS One, 13(7), e0200414. doi: 10.1371/jornal.pone.0200414.

Hoenig, M. (2012). The Cat as a Model for Human Obe-sity and Diabetes. Journal of Diabetes Science & Technology, 6(3), 525−533. doi: 10.1177/193229681200600306.

Hoenig, M. (2014). Comparative Aspects of Human, Canine and Feline Obesity and Factors Predicting Pro-gression to Diabetes. Journal of Veterinary Science, 1, 121−135. doi: 10.3390/vetsci1020121.

Kawasumi, K., Murai, T., Mizorogy, T., Okada, Y., Yamamoto, I., Suruga, K., Kadokura, K., & Arai, T. (2018). Changes in Plasma Metabolites Concentra-tions in Obese Dogs Supplemented with Anti-oxidant Compound. Journal of Frontiers in Nutrition, 5, 74–80. doi: 10.3389/fnut.2018.00074.

Keller, C., Liesegang, A., Frey, D., & Wichert, B. (2017). Metabolic Response to Three Different Diets in Lean Cats and Cats Predisposed Overweight. BMC veteri-nary research, 13, 184–191. doi: 10.1186/s12917-017-1107-3.

Marino, L.C., Lascelles, B.D.X., Vaden, S.L., Gruen, M.E., & Marks, S.L. (2014). The Prevalence and Classifica-tion of Chronic Kidney Disease in Cats Randomly Se-lected within Four Age Groups and in Cats Recruited for Degenerative Joint Disease Studies. Journal of Fe-line Medicine & Surgery, 16, 465–472. doi: 10.1177/1098612X13511446.

Meshchyshen, I.F. & Hryhorieva, N.P. (2002). Metody kilkisnoho vyznachennia SH-hrup u krovi. Buko-vyns'kyj medychnyj visnyk, 6(2), 190–192 (in Ukrainian).

Morris, J.G., & Rogers, Q.R. (1978) Arginine: An Essential Amino Acid for the Cat. Journal of Nutrition. 108(12), 1944–1055. doi: 10.1093/jn/108.12.1944.

Nguyen, P., Dumon, H., Martin, L., Siliart, B., Ferreier, L., Humbert, B., Diez, M., Breul, S., & Biourge, V. (2002). Weight Loss does not Influence Energy Expenditure or Leucine Metabolism in Obese Cats. Journal of Nu-trition, 132(6), 1649–1651. doi: 10/1093/jn/132.6.1649S.

Okada, Y., Kobayashi, M., Sawamura, M., & Arai, T. (2017). Comparison of Visceral Fat Accumulation and Metabolome Markers among Cats of Varying BCS and Novel Classification of Feline Obesity and Metabolic Syndrome. Frontiers in Veterinary Science, 4, 17. doi: 10.3389/fvets.2017.00017.

Pablack, N., & Zentek, J. (2018). Effects of Dietary Argi-nine, Ornithine and Zeolite Supplementation on Ure-mic Toxins in Cats. Toxins (Basel), 10(5), 206–218. doi: 10.3390/toxins10050206.

Shulatkina, A.V., Peshev, L.P., & Ljalichkina, N.A. (2012). Modifikacii al'buminov i sul'fgidril'nyh grupp krovi u zhenshhin s hronicheskoj venoznoj nedostat-ochnost'ju. Sovremennye problemy nauki i obra-zovanija, 6. URL: http://www.science-education.ru/ru/article/view?id=7887 (in Russian).

Vasconcellos, R.S., Borges, N.C., Gonçalves, K.N.V., Canola, J.C., de Paula, F.J.A., Malheiros, E.B., Brunet-to, M.A., & Carciofi, A.C. (2009). Protein Intake dur-ing Weight Loss Influences the Energy Required for Weight Loss and Maintenance in Cats. Journal of Nu-trition, 139, 855–860. doi: 10.3945/jn.108.103085.

Verbrugohe, A., & Bakovic, M. (2013). Peculiarities of One-Carbone Metabolism in the Strict Carnivorous Cat and Role in Feline Hepatic Lipidoses. Journal of Nutrition, 5(7), 2811–2835. doi: 10.3390/nu5072811.

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Published
2019-11-02
How to Cite
Chala, I., Rusak, V., Feshchenko, D., & Kovalyova, L. (2019). Some indices of the cats’ protein metabolism under the obesity. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(95), 36-40. https://doi.org/10.32718/nvlvet9507