Parameters of chronic toxicity of the solution for intrauterine use “Yodozol”


  • R. M. Sachuk Research Epizootology Station IVM NAAS, Rivne, Ukraine https://orcid.org/0000-0003-4532-4220
  • Ya. S. Stravsky DVNZ “Ternopil State Medical University named after I.Ya. Gorbachevsky of the Ministry of Health of Ukraine”, Ter-nopil, Ukraine
  • O. A. Katsaraba Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Pekarska Str., 50, Lviv, 79010, Ukraine https://orcid.org/0000-0001-8520-224X
  • S. V. Zhigalyuk Research Epizootology Station IVM NAAS, Rivne, Ukraine
Keywords: Yodine, potassium yodide, dose, blood, hematology, biochemistry, calving, service period, “Yodozole”.

Abstract

The study of the chronic toxicity of the solution for intrauterine use in the form of aerosol – “Yodosol”, is a mandatory stage of preclinical study of the drug, which is a new development of PE «Biopharm» and the Experimental Station of epizootology of the Institute of Infectious Diseases of NAAN. In a scientific experiment on laboratory animals, it is possible to evaluate the safety of the drug at different times of use, to determine the area of toxic action and doses that do not cause adverse health effects. Therefore, the purpose of the study was to study the chronic toxicity of the drug “Yodosol”, in particular the determination of tolerant and toxic doses for rodents. The experiments were carried out in accordance with the requirements for biomedical research, the selection of analogues for testing and control, ensuring the same conditions of feeding and retention, as well as accounting for results. “Yodosol” is a light yellow foamy liquid with 1 ml containing 5 mg iodine and 10 mg potassium iodide. The drug is used for the prevention and treatment of postpartum intrauterine infections in cows, pigs, sheep and goats (endometritis, pyrometers, cervicitis, vaginitis, delayed litter caused by iodine-sensitive microorganisms), after delivery of rhododerma, caesarean delivery and caesarean delivery. The drug has antimicrobial, anti-inflammatory and analgesic effects, improves proliferative processes in the tissues of the genital organs, helps to reduce the time of recovery of animals. The drug is used according to the guideline, after its livestock products are used without restrictions. No significant deviations in the behavior of the experimental animals were observed in the studies of chronic toxicity of the drug “Yodosol”. Visually noted only a slight inhibition of the rats of the experimental group, which received a 10-fold overdose. According to biochemical studies, in the group, compared with the control animals, there was a slight deviation of the indicators of protein metabolism and activity of hepatospecific enzymes: growth of total protein, alkaline phosphatase and aspartateaminotransferase. However, such changes in the blood parameters of the experimental animals were short-lived and restorative, characterizing the study drug as low-toxic. All studies conducted to determine the parameters of chronic toxicity of the solution for intrauterine use of “Yodosol” included in the registration materials of the medicinal product.

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Published
2019-11-02
How to Cite
Sachuk, R., Stravsky, Y., Katsaraba, O., & Zhigalyuk, S. (2019). Parameters of chronic toxicity of the solution for intrauterine use “Yodozol”. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21(95), 139-143. https://doi.org/10.32718/nvlvet9526