The treating dogs for enteropathy with PLE
One of the most common and poorly understood diseases in dogs and cats is enteropathy with PLE. The disease occurs, according to studies, in dogs of 2-6 years old breeds: Yorkshire terrier, German shepherd, and Golden Retriever. The disease in most cases is manifested by anorexia, polydipsia, diarrhea, fever up to 39.7 °C, tachycardia (145–170 bpm), and abdominal pain. In sick dogs, leucocytosis (21.0 ± 0.50 g/l), thrombocytosis (480.0 ± 10.13 g/l), oligocythaemia (4.8 ± 0.12 T/l), oligochromemia (109.0 ± 5.06 g/l), decrease in haematocrit value (29.0 ± 1.21 % in healthy people 42.3 ± 0.65 %). In a biochemical study of blood in dogs with enteropathy with PLE, hypoproteinaemia (38.2 ± 0.65 g/l), hypoalbuminemia (9.6 ± 0.61 g/l); hyperazotemia (8.6 ± 0.37 mmol/l), hypercholesterolemia (8.0 ± 0.23 mmol/l), hyperenzymemia of LF (ALP) and ALT (alanine aminotransferase), hyponatremia, hypokalaemia, hypochloraemia, decreased blood pH values (7.26 ± 0.013), HCO3- (15.3 ± 0.71 mmol/L) and AG (2.85 ± 0.084 mmol/L, in healthy people 14.3 ± 1.17 mmol/L). The diagnosis of enteropathy with PLE was confirmed by studies in feces of α1-antitrypsin, which in sick dogs with PLE was more than 22 mg/dL (in clinically healthy dogs up to 18 mg/dL). A treatment regimen with trometamol, Xylat, Disparkol, Voluven, Reopoliglukin, Maropitant, prednisolone, α-lysine escinat, albumin, Presorb and feed additives Vivonex Ten Elemental and Royal Canin Recoveri promotes the recovery of dogs, prevents their death. Under the action of drugs, erythro- and leuсocytopoiesis, protein-synthesizing (the content of total protein and albumin increased by 34.3 and 246.9 %, respectively) and urea-forming functions of hepatocytes improves. We have developed and tested a treatment scheme that restores the acid-base balance of the body, as indicated by the physiological values of blood pH, bicarbonates, anion gap (AG), Na+, K+, Cl- and Mg+.
Baez, J. L., Hendrick, M. J., Walker, L. M., et al. (1999). Radiographic, ultrasonographic, and endoscopic find-ings in cats with inflammatory bowel disease of the stomach and small intestine: 33 cases (1990–1997). Journal of the American Veterinary Medical Association, 215(3), 349–354. URL: https://pubmed.ncbi.nlm.nih.gov/10434972.
Bailey S., Benigni L., Eastwood J. et al. (2010). Compari-sons between cats with normal and increased fPLI concentrations in cats diagnosed with inflammatory bowel disease. Journal of Small Animal Practice, 51(9), 484–9. doi: 10.1111/j.1748-5827.2010.00973.x.
Bush, W. W., Kimmel, S. E., Wosar, M. A. et al. (2001). Secondary hypoparathyroidism attributed to hypo-magnesemia in a dog with protein-losing enteropathy. Journal of the American Veterinary Medical Association, 219(12), 1732–1734. doi: 10.2460/javma.2001.219.1732.
Craven, M., Duhamel, G. E., Sutter, N. B. et al. (2009). Absence of bacterial association in Yorkshire terriers with protein-losing enteropathy and cystic intestinal crypts. Journal of Veterinary Internal Medicine, 23, 757.
Dossin, O., & Lavoué, R. (2011). Protein-losing enteropathies in dogs. Veterinary Clinics of North America: Small Animal Practice, 41(2), 399–418. doi: 10.1016/j.cvsm.2011.02.002.
Higgins, C. (2009). Clinical aspects of the anion gap. URL: www.acutecaretesting.org.
Holovakha, V., Mostovyi, Y., Sliusarenko, S., Piddubniak, O., Tyshkivskyi, M., Koreniev, N., Matsynovych, A., & Belko, A. (2019). Clinical and biochemical changes in dogs with PLE enteropathy. Scientific notes of the Educational Institution “Vitebsk Order “Sign of Hon-or” State Academy of Veterinary Medicine”, 55(3), 18–24. URL: https://www.vsavm.by/wp-content/uploads/2013/11/2019-Uchenye-zapiski-t-55-v-3.pdf.
Jergens, A. E. (1999). Inflammatory bowel disease. Cur-rent perspectives. Veterinary Clinics of North Ameri-ca: Small Animal Practice, 29(2), 501–521. URL: https://pubmed.ncbi.nlm.nih.gov/10202800.
Jergens, A. E., Moore, F. M., Haynes, J. S., et al. (1992). Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987–1990). Journal of the American Veterinary Medical Association, 201(10), 1603–1608. URL: https://pubmed.ncbi.nlm.nih.gov/1289345.
Kimmel, S. E., Waddell, L. S., & Michel, K. E. (2000). Hypomagnesemia and hypocalcemia associated with protein-losing enteropathy in Yorkshire terriers: five cases (1992– 1998). Journal of the American Veterinary Medical Association, 217(5), 703–706. doi: 10.2460/javma.2000.217.703.
Kishkun, A. A. (2014). Biochemical research in clinical practice: A guide for physicians, “Publishing house” Medical information agency (in Russian).
Kull, P. A., Hess, R. S., Craig, L. E., et al. (2001). Clinical, clinicopathologic, radiographic, and ultrasonographic characteristics of intestinal lymphangiectasia in dogs: 17 cases (1996–1998). Journal of the American Veter-inary Medical Association, 219(2), 197–202. doi: 10.2460/javma.2001.219.197.
Lecoindre, P., Chevallier, M., & Guerret, S. (2010). Pro-tein-losing enteropathy of non neoplastic origin in the dog: a retrospective study of 34 cases. Schweiz Arch Tierheilkd, 152(3), 141–146. doi: 10.1024/0036-7281/a000033 (in French).
Levchenko, V. I., Holovakha, V. I., Kondrakhin, I. P. et al. (2010). Methods of laboratory clinical diagnosis of animal diseases. URL: http://rep.btsau.edu.ua/ handle/BNAU/467 (in Ukrainian).
Levchenko, V. I., Vlizlo, V. V., Kondrakhin, I. P. et al. (2017). Clinical diagnosis of animal diseases, Bila Tserkva URL: http://rep.btsau.edu.ua/handle/BNAU/298 (in Ukrain-ian).
Mellanby, R. J., Mellor, P. J., Roulois, A. et al. (2005). Hypocalcaemia associated with low serum vitamin D metabolite concentrations in two dogs with protein-losing enteropathies. Journal of Small Animal Prac-tice, 46(7), 345–351. doi: 10.1111/j.1748-5827.2005.tb00331.x.
Meyer, D., & Harvey, J. (2007). Veterinary laboratory medicine. Interpretation and diagnostics, Moscow, Sofion (in Russian).
Motuzko, I. S. et al. (2008). Physiological indicators of animals: a reference book, Minsk: Technoperspektiva, 95.
Peterson, P. B., & Willard, M. D. (2003). Protein-losing enteropathies. Veterinary Clinics of North America: Small Animal Practice, 33(5), 1061–1082. doi: 10.1016/s0195-5616(03)00055-x.
Rovenská, E., & Rovenský, J. (2011). Lymphatic vessels: structure and function. The Israel Medical Association Journal, 13(12), 762–768.
Simpson, K. W., & Jergens, A. E. (2011). Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Veterinary Clinics of North America: Small Animal Practice, 41(2), 381–398. doi: 10.1016/j.cvsm.2011.02.003.
Trofim’jak, R. M., & Slivins’ka, L. G. (2020). Indicators of hematopoiesis and biochemical profile of dogs' blood in chronic heart failure. Scientific Bulletin of Veterinary Medicine. Bila Tserkva, 1, 47–54.
Willard, M. (2015). Canine Protein Losing Enteropathies. Texas A&M University, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas, USA Israel Journal of Veterinary Medicine, 70(3), 17–20. URL: https://pdfs.semanticscholar.org/ bd8b/3bb28874ef45fd25d12f0268df81ffec8c81.pdf.
Abstract views: 0 PDF Downloads: 0