Clinical characteristics of mastocytoma in dogs


Keywords: dogs, skin tumors, mastocytoma, spread, cytological examination, clinical signs, sono and radiography.

Abstract

According to foreign researchers, mastocytoma is one of the most common (7-12 %) skin tumors in dogs. This neoplasia is caused by excessive proliferation of mast cells and characterized by a specific clinical course, unpredictable biological behavior and prognosis. Researches of clinical and morphological features of mastocytoma in geographical populations of Ukraine has not only scientific and general biological interest, but also important practical significance. The purpose of the research was to establish the frequency of spreading, the features of the clinical ostent and pathogenesis of cutaneous mastocytoma in dogs in conditions in Lviv and in the suburban zone of the regional center. The research was performed on dogs with skin tumors (n = 128), including 24 of them with mastocytoma, who came to the Department of Surgery and Clinic of Small Pets of Stepan Gzhytskyj LNUVMB during 2016–2020. The diagnosis on mastocytoma was verified by the results of physical examination and cytological examination of biopsy material of neoplasms. It was found that in the structure of oncological diseases of dogs the share of skin neoplasms was 32.16 %. Among animals with skin neoplasms, mastocytoma was diagnosed in 18.75 % of dogs aged 4 to 16 years. The highest incidence rates were found among animals aged 8 to 11 years; the median incidence was 9.5 years and fashion – 9 years. In terms of breeds, cutaneous mastocytoma was found in dogs of the breed: Rottweiler – 16.7 %, Sharpei – 12.5 %, Staffordshire Terrier – 12.5 %, Labrador – 8.3 %, Boxer – 8.3 %, Doberman – 8.3 %, chow-chow – 8.3 %. At the same time, the German Shepherd, Alabai, Spaniel, French Bulldog and Pug cases of the disease were isolated (4.2 %). Among sick animals, dogs accounted for 54.2 % and females for 45.8 %. It was found that in 41.7 % of the studied animals the rate of neoplasia was extremely rapid, because in 56.5 ± 1.91 days the tumors were doubled in size, which is evidence of significant aggressiveness of tumor growth. In 29.2 % of dogs the time of doubling the size of the primary tumor reached 122.1 ± 10.6 days, in 20.8 % of dogs the period of tumor development lasted for two years. In 8.3 % of dogs, the dynamics of neoplasia development is not clear. Sonography has shown that skin mastocytomas are usually visualized as heterogeneous, with uneven edges and fuzzy contours hypoechoic structures. Visualization of solid hypervascular foci with central type of vascularization, on the background of diffuse infiltration of neoplasia in the deeper layers of the skin and subcutaneous tissue, with a pronounced perinodular inflammatory reaction of the surrounding tissues is a sign of malignancy of the mastocytoma. The generalization of the neoplastic process in the internal organs was found, in particular the spleen, may indicate a predominance of the hematogenous route of metastasis of the mastocytoma. The obtained data complement and expand knowledge about the pathogenesis of mastocytoma in dogs, and also highlight the frequency of spreading and course features of this oncological pathology in a separate geographical population of Ukraine.

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References

Akin, C. (2020). Mastocytosis: A Comprehensive Guide. Springer Nature, Switzerland AG. 307 p. doi: 10.1007/978-3-030-27820-5.

Akin, C., Valent, P., & Metcalfe, D. D. (2010). Mast cell activation syndrome: Proposed diagnostic criteria. J Allergy Clin Immunol, 126(6), 1099–1104.e4. doi: 10.1016/j.jaci.2010.08.035.

Alvarez-Twose, I., Jara-Acevedo, M., Morgado, J. M., Garcıa-Montero, A, Sanchez- Munoz, L., Teodosio, C., et al. (2016). Clinical, immunophenotypic, and molecular characteristics of well-differentiated sys-temic mastocytosis. J Allergy Clin Immunol, 137(1), 168–178. doi: 10.1016/j.jaci.2015.05.008.

Bautista-Quach, M. A., Booth, C. L., Kheradpour, A., Zuppan, C. W., Rowsell, E. H., Weiss, L., & Wang, J. (2013). Mast cell sarcoma in an infant: a case report and review of the literature. J Pediatr Hematol Oncol, 35(4), 315–320. doi: 10.1097/MPH.0b013e318279e392.

Beer, P., Pozzi, A., Rohrer Bley, C., Bacon, N., Pfammatter, N. S., & Venzin, C. (2018). The role of sentinel lymph node mapping in small animal veterinary medicine: A comparison with current approaches in human medicine. Vet Comp Oncol, 16(2), 178–187. doi: 10.1111/vco.12372.

Blackwood, L. (2011). Manual of Canine and Feline Oncology. BSAVA Manual of Canine and Feline Oncology. doi: 10.22233/9781905319749.12.

Blackwood, L., Murphy, S., Buracco, P. et al. (2012). European consensus document on mast cell tumours in dogs and cats. Vet Comp Oncol, 10(3), e1-e29. doi: 10.1111/j.1476-5829.2012.00341.x.

Dobson, J. M. (2013). Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci., 2013, 941275. Epub 2013/06/06. doi: 10.1155/2013/941275.

Frieri, M., & Quershi, M. (2013). Pediatric Mastocytosis: A Review of the Literature. Pediatr Allergy Immunol Pulmonol, 26(4), 175–180. doi: 10.1089/ped.2013.0275.

Frolova, T. V., Tereshchenkova, I. I., & Stenkova, N. F. (2018). Mastotsytoz u praktytsi simeinoho likaria. Skhidnoievropeiskyi zhurnal vnutrishnoi ta simeinoi medytsyny, 1(8), 22–26. doi: 10.15407/internalmed 2018.01.022 (in Ukrainian).

Garden, O. A., Volk, S. W., Mason, N. J., & Perry, J. A. (2018). Companion animals in comparative oncology: One Medicine in action. The Veterinary Journal, 240, 6–13. doi: 10.1016/j.tvjl.2018.08.008.

Gargiulo, G. (2018). Next-Generation in vivo Modeling of Human Cancers. Front. Oncol., 8, 429. doi: 10.3389/fonc.2018.00429.

Garrett, L. (2014). Canine mast cell tumors: diagnosis, treatment, and prognosis. Vet Med (Auckl), 2014(5), 49–58. doi: 10.2147/VMRR.S41005.

Grüntzig, K., Graf, R., Hässig, M., et al. (2015). The Swiss Canine Cancer Registry: a retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol, 152(2–3), 161–171. doi: 10.1016/j.jcpa.2015.02.005.

Gülen, T., Hägglund, H., Dahlén, B, & Nilsson, G. (2016). Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease. Journal of International Medicine, 379(3), 211–228. doi: 10.1111/joim.12410.

Hartmann, K. et al. (2016). Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol, 137(1), 35–45. doi: 10.1016/j.jaci.2015.08.034.

Hsu, F. I., & Boyce, J. A. (2009). Biology of mast cells and their mediators. In: Adkinson Jr N. F., Busse W. W., Bochner B. S., Holgate S. T., Simons F. E. R., Lemanske Jr R. F., editors. Middleton’s allergy: principles & practice. 7th ed. Philadelphia: Mosby/Elsevier, 311–328.

Ivashkiv, B. B., Mysak, A. R., Khomyn, N. M., & Pritsak, V. V. (2019). Monitorynh poshyrennia spontannykh neoplazii u sobak v umovakh m. Lviv ta v prymiskii zoni oblasnoho tsentru. Naukovyi visnyk veterynarnoi medytsyny. Zbirnyk naukovykh prats, 2(152), 97–104. doi: 10.33245/2310-4902-2019-152-2-97-104 (in Ukrainian).

Leguit, R., Hebeda, K., Kremer, M., van der Walt, J., Gianelli, U., Tzankov, A., & Orazi, A. (2020). The Spectrum of Aggressive Mastocytosis: A Workshop Report and Literature Review. Pathobiology, 87, 2–19. doi: 10.1159/000504099.

Lieshchova, M. O. Shuleshko, O. O., & Balchuhov, V. O. (2018). Poshyrennia i struktura novoutvoren tvaryn u misti Dnipro. Naukovo-tekhnichnyi biuleten Naukovo-doslidnoho tsentru biobezpeky ta ekolohichnoho kontroliu resursiv APK, 6(2), 30–37 (in Ukrainian).

Lisickaja, K. V., & Sedov, S. V. (2011). Mastocitoma sobak: jetiologija, klinika, diagnostika i lechenie. VetPharma, 3–4, 94–99 (in Russian).

Misdorp, W. (2004). Mast cells and canine mast cell tumours. A review. Veterinary Quarterly, 26(4), 156–169. doi: 10.1080/01652176.2004.9695178.

Murphy, S., Sparkes, A. H., Blunden, A. S., Brearley, M. J., & Smith, K. C. (2006). Effects of stage and number of tumours on prognosis of dogs with cutaneous mast cell tumours. The Veterinary Record, 158(9), 287–291. doi: 10.1136/vr.158.9.287.

Mykhailenko, N. I., & Voitsekhovych, D. V. (2017). Orhanna lokalizatsiia pukhlyn u dribnykh tvaryn riznykh vydiv. Naukovyi visnyk LNUVMtaBT imeni S.Z. Gzhytskoho, 19(77), 162–165. doi: 10.15421/nvlvet7735 (in Ukrainian).

Mysak, A. R. (2012). Problema neoplazii u produktyvnykh i dribnykh domashnikh tvaryn. Naukovyi visnyk LNUVMtaBT imeni S. Z. Gzhytskoho, 14, 2(52), 250–255. URL: https://nvlvet.com.ua/index.php/journal/issue/view/37/37 (in Ukrainian).

Okhotnikova, O. M., Sharikadze, O. V., & Hryshchenko, O. M. (2018). Syndrom aktyvatsii mastotsytiv: suchasnyi pohliad na problemu. Klinichna imunolohiia. Alerholohiia. Infektolohiia, 2(107), 6–14 (in Ukrainian).

Owen, L. N. (1980). TNM Classification of Tumors in Domestic Animals. Geneva: World Health Organization.

Pardanani, A. (2016). Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management. American Journal of Hematology, 91(11), 1146–1159. doi: 10.1002/ajh.24553.

Shoop-Worrall, S., Marlow, S., Church, D., English, K., McGreevy, P., Stell, A., Thomson, P., O'Neill, D., & Brodbelt, D. (2015). Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genetics and Epidemiolgy, 2, 1. doi: 10.1186/2052-6687-2-1.

Sledge, D. G., Webster, J., & Kiupel, M. (2016). Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection. Vet J., 215, 43–54. doi: 10.1016/j.tvjl.2016.06.003.

Smiech, A., Slaska, B., Lopuszynski, W., Jasik, A., Bochyńska, D., & Dąbrowski, R. (2018). Epidemiological assessment of the risk of canine mast cell tumours based on the Kiupel two-grade malignancy classification. Acta Veterinaria Scandinavica, 60. doi: 10.1186/s13028-018-0424-2.

Tamlin, V. S., Bottema, C. D. K., & Peaston, A. E. (2020). Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment. Vet Med Sci, 6, 3–18. doi: 10.1002/vms3.201.

Valent, P., Akin, C., Arock, M., et al. (2012). Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int Arch Allergy Immunol, 157(3), 215–225. doi: 10.1159/000328760.

Valent, P., Akin, C., Hartmann, K. et al. (2017). Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Res, 77(6), 1261–1270. doi: 10.1158/0008-5472.CAN-16-2234.

Valent, P., Sotlar, K., Sperr, W. R., Reiter, A., Arock, M., & Horny, H. P. (2015). Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features. Leuk Res, 39(1), 1–5. doi: 10.1016/j.leukres.2014.09.010.

Villamil, J. A., Henry, C. J., Bryan, J. N., et al. (2011). Identification of the most common cutaneous neo-plasms in dogs and evaluation of breed and age dis-tributions for selected neoplasms. J Am Vet Med Assoc, 239 (7), 960–965. doi: 10.2460/javma.239.7.960.

Weishaar, K. M., Thamm D. H., Worley, D. R., & Kamstock, D. A. (2014). Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis. J Comp Pathol, 151(4), 329–338. doi: 10.1016/j.jcpa.2014.07.004.

Willmann, M., Hadzijusufovic, E., Hermine, O. et al. (2018). Comparative Oncology: the Paradigmatic Example of Canine and Human Mast Cell Neoplasms. Veterinary and Comparative Oncology, 17(1), 1–10. doi: 10.1111/vco.12440.

Zon, H. A., Ivanovska, L. B., & Dobia, M. V. (2013). Rezultaty diahnostyky pukhlyn sobak v m. Sumy. Vis-nyk Sumskoho natsionalnoho ahrarnoho universytetu. Seriia: Veterynarna medytsyna, 9, 171–174. URL: http://nbuv.gov.ua/UJRN/Vsna_vet_2013_9_53 (in Ukrainian).

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Published
2020-08-22
How to Cite
Ivashkiv, B., Mysak, A., & Pritsak, V. (2020). Clinical characteristics of mastocytoma in dogs. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(98), 144-153. https://doi.org/10.32718/nvlvet9825

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