Plasma replacement solutions in the intensive care unit of shock for acute spontaneous canine babesiosis

Keywords: acute spontaneous canine babesiosis, shock, plasma-substitute, Rheopolyglucinum, Rheosorbilact, colloidal solution, crystalloidal solution


The article presents the results of studies on the study of secondary processes that develop during acute spontaneous babesiosis in dogs, as well as on the use of infusion therapy with plasma substitutes for the development of shock as a complication of the underlying disease. It is shown that acute blood parasitic disease is accompanied by the development of moderate subcompensated shock, which determines the state of unstable equilibrium and the tendency to avalanche-like disorders due to the transition of the process to the decompensated phase. The basis for the diagnosis of the shock state was the establishment of the following hemodynamic and hemorheological changes: hypovolemia with a decrease of all blood components (shaped elements and plasma components) in the circulation, a significant decrease in the specific volume of circulating blood, hematocrit value, a significant increase in spontaneous aggregation of shaped blood elements (platelets and red blood cells), hypotension, an increase in the Algver shock index by almost 2 times. There was a significant deficit in the volume of circulating blood (the degree of blood loss), which was about 30 %. It is shown that the presence of a state of shock in the subcompensation stage poses a threat to the life of the animal in the event of transition to the terminal stage. In order to stop the development of shock, infusion therapy was used with the most common plasma–substituting solutions – Rheopolyglucin and Rheosorbylact at a dose of 5 ml/kg of body weight intravenously drip per day for 3 days. A comparative assessment of the effect of drugs on the correction of major hemodynamic and hemorheological shifts was carried out. It was found that Rheopolyglucin as a colloidal plasma substitute has a better effect on the normalization of hemodynamic disorders – hypovolemia and hypotension, and Rheosorbylact as a crystalloid plasma substitute turned out to be the best disaggregant and reducing agent of hemorheological disorders. Both drugs provided a complete recovery of hemodynamic and hemorheological parameters in 72 hours. As a result, it is recommended to use a combination of drugs with the priority of Rheopolyglucin in the first hours of treatment and combine it with an infusion of Rheosorbylact in subsequent days.


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Annane, D., Siami, S., Jaber, S. et al. (2013). Effects of fluid resuscitation with colloids vs crystalloids on mor-tality in critically ill patients presenting with hypovo-lemic shock: the CRISTAL randomized trial. JAMA, 310(17), 1809–1817. doi: 10.1001/jama.2013.280502.

Dubova, O. A. (2016). Shock and DIC–syndrome as a pathogenetic axis of dogs babesiosis. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 18, 2(66), 70–73. doi: 10.15421/nvlvet6615 (in Ukraini-an).

Dubova, O. A., Feshchenko, D. V., Bakhur, T. I., Zghozinska, O. A., Antipov, A. A., Rublenko, S. V., Goncharenko, V. P., Shahanenko, R. V., & Sha-hanenko, V. S. (2020). Disseminated intravascular coagulation syndrome as a complication in acute spontaneous canine babesiosis. Mac Vet Rev, 43(2), 1–9. doi: 10.2478/macvetrev-2020-0027.

Dubova, O., Dubovyi, A., & Feshchenko, D. (2018). Indi-rect evaluation method and parameters of blood pres-sure and its indexes in dogs. Sci Mes LNU Vet Med Biotechnol. Series: Vet Sci., 20(88), 80–84. doi: 10.32718/nvlvet8814 (in Ukrainian).

Hahn, R. G. (2017). Crystalloid and Colloid Fluid. Essen-tials of Neuroanesthesia, 2017, 827–832 doi: 10.1016/B978-0-12-805299-0.00050-6.

Holovakha, V. I., Piddubnуak, О. V., Bakhur, T. I., Vovkotrub, N. V., Antipov, A. A., Anfiorova, M. V., Gutyj, B. V., Slivinska, L. G., Kurdeko, O. P., & Ma-cynovich, A. O. (2018). Changes in erythrocytopoesis indices in dogs with babesiosis. Regulatory Mecha-nisms in Biosystems, 9(3), 379–383. doi: 10.15421/021856.

Köster, L. S., Lobetti, R. G., & Kelly, P. (2015). Canine babesiosis: a perspective on clinical complications, bi-omarkers, and treatment. Vet Med (Auckl), 6, 119–128. doi: 10.2147/VMRR.S60431.

Langer, T., Ferrari, M., Zazzeron, L., Gattinoni, L., Cairo-ni, P. (2014). Effects of intravenous solutions on acid-base equilibrium: from crystalloids to colloids and blood components. Anaesthesiology intensive thera-py, 46(5), 350–360. doi: 10.5603/AIT.2014.0059.

Lee, J. J., & Kim, J. H. (2013). Plasma volume expanders: Classification and characteristics of colloids. Journal of the Korean Medical Association, 56(10), 924–932. doi: 10.5124/jkma.2013.56.10.924.

Leone, M., Asfar, P., Radumacher, P., Vincent, J. L., & Martin, C. (2015). Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature. Crit Care, 19(1), 191. doi: 10.1186/s13054-015-0794-z.

Levi, M. (2018). Disseminated Intravascular Coagulation. Hematology, (7th Ed.), 2064–2075. doi: 10.1016/B978-0-323-35762-3.00139-6.

Lewis, S. R., Pritchard, M. W., Evans, D. J. W., Butler, A. R., Alderson, P., Smith, A. F., & Roberts, I. (2018). Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database of Systematic Reviews, 8, CD000567. doi: 10.1002/14651858.CD000567.pub7.

Monteiro, J. N. (2017). Fluids and Electrolyte Manage-ment. Essentials of Neuroanesthesia, 2017, 815–825. doi: 10.1016/B978-0-12-805299-0.00049-X.

Nathan, H. L., Cottan, K., Hezelgrave, N. L., Seed, P. T., Briley, A., Bewley, S., Chappell, L. C., & Shennan, A. H. (2016). Determination of normal ranges of shock index and other haemodynamic variables in immedi-ate postpartum period: a cohort study. PloS One, 11(12), e0168535. doi: 10.1371/journal.pone.0168535.

Schorn, M. N. (2010). Measurement of blood loss: review of the literature. J Midwifery Womens Health, 55(1), 20–27. doi: 10.1016/j.jmwh.2009.02.014.

Solano-Gallego, L., & Baneth, G. (2011). Babesiosis in dogs and cats-expanding parasitological and clinical spectra. Vet Parasitol, 181(1), 48–60. doi: 10.1016/j.vetpar.2011.04.023.

Soroka, N. M., & Dubova, O. A. (2005). inventors; Na-tional Agrarian University, assignee. Method of life-long diagnosis of disseminated intravascular coagula-tion syndrome in dogs. Ukraine patent U 200503510. 2005 Sept 15 (in Ukrainian).

Soroka, N. M., Dubova, O. A., & Iaremenko, D. O. (2005). inventors; National Agrarian University, assignee. A method of determining the volume of circulating blood in dogs. Ukraine patent U 2200505490. 2005 Jun 8 (in Ukrainian).

Strengers, P. F. W., & Velthove, K. J. (2011). Blood, blood components, plasma, and plasma products. Side Ef-fects of Drugs Annual, 33, 669–690. doi: 10.1016/B978-0-444-53741-6.00033-7.

Vincent, J. L., & De Backer, D. (2013). Circulatory shock. N Engl J Med, 369, 1726. doi: 10.1056/NEJMra1208943.

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How to Cite
Dubova, O., Feshchenko, D., Goralska, I., Duboviy, A., Zghozinska, O., & Chala, I. (2020). Plasma replacement solutions in the intensive care unit of shock for acute spontaneous canine babesiosis. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(99), 38-44.