Influence of “Metisevit” feed additive and liposomal preparation “Lipointersil” on the level of vitamins in the blood of bulls at experimental chronic cadmium toxicosis


  • Yu. Yu. Lavryshyn Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-2774-6844
  • B. V. Gutyj Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-5971-8776
  • M. I. Zhyla State scientific research control institute of veterinary preparations and feed additives, Lviv, Ukraine https://orcid.org/0000-0003-1206-168X
  • L. V. Kurylas State scientific research control institute of veterinary preparations and feed additives, Lviv, Ukraine https://orcid.org/0000-0003-1685-1144
  • V. Ya. Prysiazhniuk Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0001-8932-9512
  • I. I. Khariv Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine https://orcid.org/0000-0002-5844-9359
  • V. V. Voroniak Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine
Keywords: toxicology, cadmium, vitamins, bulls, feed additive, liposomal preparation

Abstract

The article presents the results of research on the effect of feed additive Metisevit and liposomal drug Lipointersil on the level of vitamins in the blood of bulls in experimental chronic cadmium toxicosis. The research was conducted on the basis of a farm in the village of Ivanivtsi, Zhydachiv district, Lviv region, on 15 bulls of six months of age, Ukrainian black-spotted dairy breed, which were formed into 3 groups of 5 animals each: control and two experimental groups. The bulls of the control group were fed cadmium chloride at a dose of 0.04 mg/kg body weight for 30 days. The bulls of the first experimental group were fed cadmium chloride at a dose of 0.04 mg/kg body weight for 30 days and fed a dietary supplement Metisevit at a dose of 0.36 g/kg of feed. The bulls of the second experimental group were fed cadmium chloride at a dose of 0.04 mg/kg body weight for 30 days and fed a dietary supplement Metisevit in the above dose. On the first and seventh days of the experiment, bulls of this experimental group were injected intramuscularly with liposomal drug Lipointersil at a dose of 5 ml per animal. The composition of the liposomal drug Lipointersil includes interferon and milk thistle. In the study of the non-enzymatic part of the antioxidant system of the body of bulls under cadmium load found a decrease in vitamins A and E. The use of feed additive “Metisevit” increased the content of vitamin E in the blood of bulls of the second experimental group by 10.5 % experiment – by 37.9 % relative to the control group. With the additional use of liposomal drug “Lipointersil” in the blood of bulls found a more likely increase in vitamin E levels throughout the experiment than in the second experimental group, where respectively on the 15th and 20th day of the experiment, this figure increased by 35.3 and 55.1 %. The increase in the content of vitamin E in the blood of experimental animals is due to the feeding of the feed supplement “Metisevit”, which contains this vitamin. A similar increase is observed in the study of vitamin A in the blood of bulls of experimental groups. It was found that when using a feed additive and liposomal preparation for bulls, on the 15th day of the experiment the level of vitamin A in the blood of the first experimental group increased by 19.4 %, and in the blood of the second experimental group – by 26.9 % relative to the control group. Thus, the use of feed supplement “Metisevit” and liposomal drug “Lipointersil” for bulls, which are under conditions of cadmium load, helped to increase the non-enzymatic system of antioxidant protection, namely vitamins A and E.

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Published
2020-12-23
How to Cite
Lavryshyn, Y., Gutyj, B., Zhyla, M., Kurylas, L., Prysiazhniuk, V., Khariv, I., & Voroniak, V. (2020). Influence of “Metisevit” feed additive and liposomal preparation “Lipointersil” on the level of vitamins in the blood of bulls at experimental chronic cadmium toxicosis. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(100), 88-93. https://doi.org/10.32718/nvlvet10016

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