Features of the usage of antibiotics in herpetology


Keywords: reptiles, antibiotics, portal venous system of kidneys, bacterial infections of reptiles.

Abstract

The article summarizes the literature data on the frequency and causes of diseases of reptiles, the peculiarities of their infection with bacterial microorganisms, the use of antimicrobial drugs and the development of antibiotic resistance. It should be noted that the use of antibiotics and other antimicrobial drugs in veterinary herpetology has its own characteristics, due primarily to the peculiarities of thermoregulation and metabolism in reptiles, the nature of the pathogenic microflora inherent in these animals. In reptiles, infection with gram-negative microorganisms is more common: enterobacteria (salmonella, Escherichia coli, Proteus) and gram-positive bacteria (staphylococci and streptococci), as well as saprophytes belonging to the group of spore-forming microorganisms. Some species of actinomycetes show quite pronounced pathogenic activity as well. Reptiles suffer from salmonellosis or are salmonella carriers. In such cases, conditions are created for the potential infection of humans with salmonella, most often infecting children and the elderly who come into contact with sick reptiles. Other anthropozoonoses (eschiriosis, leptospirosis, chlamydia, campylobacteriosis, streptococcal and staphylococcal infections, fungal infections, etc.) are dangerous as well. Antibiotics were prescribed to sick reptiles “at the beginning” of the development of veterinary herpetology. The effectiveness of antimicrobial drugs depends on many factors (species, age and sex of reptiles, their physiological state: temperature, metabolic rate, the presence of underlying and comorbidities, the type of bacteria that infect reptiles and their resistance to antibacterial drugs, etc.). Unlike mammals, reptiles have a portal venous system of the kidneys, which is represented by a system of veins, through which much of the venous blood from the back of the body enters the portal vein of the kidneys, which breaks down into a system of capillaries isolated many toxic compounds, including antibiotics. Thus, the portal venous system of the kidneys, together with the portal venous system of the liver play an important role in the metabolism and excretion of most antibiotics. Taking into account the potential nephrotoxicity of antibiotics and the possibility of their rapid excretion from the body (due to the presence of the portal venous system of the kidneys), most herpetologists recommend parenteral administration of drugs to reptiles in the front of the body. Thus, when choosing and using antibacterial drugs for the treatment of infectious diseases of reptiles should take into account a number of morpho-functional features of reptiles, sensitivity of microorganisms to antibiotics, choose the right dose, frequency, method and place of administration, consider the possibility of complications.

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References

Ahmed, A., & Rasha, E. (2013). Comparative histological, histochemical and ultrastructural studiesof the nephron of selected snakes from the Egyptian area. Biologia, 68/3, 546–558. doi: 10.2478/s11756-013-0181-7.

Bannai, M., Mohammad, E., Shamary, A., Najjar, K., & Al-Khwaja, F. (2017). Contribution and pathology of e. Coli and pseudomonas aeruginosa bacterial infection on soft shell turtle rafetus euphraticus (gray, 1864) east hammar marshes, IRAQ. Ruussian journal of parasathology, 40(2), 174–178.

Carini, A., Ariel, E., Picard, J., & Elliott, L. (2017). Antibiotic Resistant Bacterial Isolates from Captive Green Turtles and In Vitro Sensitivity to Bacteriophages. International Journal of Microbiology. doi: 10.1155/2017/5798161.

Corum, O., Corum, D., Altan, F., Ee, A., Centin, G., & Uney, K. (2019). Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans) J. Vet. Med. Sci., 81(5),753–757. doi: 10.1292/jvms.18-0609.

Dantzler, W., & Braun, E. (1980). Comparative nephron function in reptiles, birds, and mammals. American Journal of Physiology-Regulatory, 239(3), 197–213. doi: 10.1152/ajpregu.1980.239.3.R197.

Dustin, M., Grayson, A., Kurt, K., & Christoph, M. (2018). Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius). Journal of the American Veterinary Medical Association. 253(9), 1146–1150. doi: 10.2460/javma.253.9.1146.

Holz, P. (2020). Anatomy and Physiology of the Reptile Renal System. Vet Clin North Am Exot Anim Pract, 23(1), 103–114. doi: 10.1016/j.cvex.2019.08.005.

Holz, P., & Barker, I. (2012). Reptiles. Diagnostic Pathology ofthe Diseases of Aquatic, Aerial and Terrestrial Wildlife, Australian Registry of WildlifeHealth, Sydney, NSW, 50–62.

Holz, P., Barker, I., Crawshaw, G., & Dobson, H. (1998). The anatomy and perfusion of the renal portal system in the red-eared slider (trachemys scripta elegans). Journal of Zoo and Wildlife Medicine, 28(4), 378–385. URL: https://pubmed.ncbi.nlm.nih.gov/9523630.

Holz, P., Barker, K., Burger, J., Crawshaw, J., & Peter, D. (1997). The Effect of the Renal Portal System on Pharmacokinetic Parameters in the Red-Eared Slider (Trachemys scripta elegans). Journal of Zoo and Wildlife Medicine, 28(8), 386–393. URL: https://pubmed.ncbi.nlm.nih.gov/9523631.

Isaza, R., & Jacobson, E. (2013). Antimicrobial Drug Use in Reptiles. Antimicrobial Therapy in Veterinary Medicine. doi: 10.1002/9781118675014.ch37.

Işler, C., & Secer, F. (2015). Treatment of Bath with Enrofloxacin in Red-Eared Sliders (Trachemys scripta elegans) Suffer from Conjunctivitis and Its Results. Kafkas Univ Vet FakDerg, 21(3), 429–431. doi: 10.9775/kvfd.2014.12621.

Jacobson, E., MGaskin, J., Brown, M., Harris, R., Gardiner, C., LaPointe, J., Adams, H., & Reggiardo, C. (1991). Chronic upper respiratory tract disease of free-ranging desert tortoises (Xerobates agassizii). J Wildl Dis., 2, 296–316. doi: 10.7589/0090-3558-27.2.296.

Jarofke, D., & Lande, Ju. (2012). Reptilii bolezni i lechenie. Moskva: AKVARIUM-PRINT (in Russian).

Liu, D., Wilson, C., Hearlson, J., Singleton, J., Thomas, R., & Crupper, S. (2013). Prevalence of antibiotic-resistant Gram-negative bacteria associated with the red-eared slider (Trachemys scripta elegans). J ZooWildlMed, 44(3), 666–671. doi: 10.1638/2012-0252R1.1.

Mader, D., & Divers, S. (2014). Divers Current Therapy in Reptile Medicine and Surgery. URL: https://www.sciencedirect.com/book/9781455708932/current-therapy-in-reptile-medicine-and-surgery.

Montali, R., Bush, M., & Smeller, J. (1979). The Pathology of Nephrotoxicity of Gentamicin in Snakes. Vet. Pathol., 16(1), 108–115. doi: 10.1177/030098587901600111.

Orós, J., Torrent, A., Calabuig, P., & Déniz, S. (2005). Diseases and causes of mortality among sea turtles stranded in the Canary Islands, Spain (1998-2001). Dis Aquat Organ, 63(1), 13–24. doi: 10.3354/dao063013.

Pincheira-Donoso, D., Bauer, A., Meiri, S., & Uetz, P. (2013). Global Taxonomic Diversity of Living Reptiles. PLOS ONE, 1–10. doi: 10.1371/journal.pone.0059741.

Robinson, E., Freya A., Richard, A., & Roberts, G. (2015). Captive Reptile Mortality Rates in the Home and Implications for the Wildlife Trade. PLOS ONE, 1–14. doi: 10.1371/journal.pone.0141460.

Santoro, M., Hernández, G., & Caballero, M. (2006). Aerobic bacterial flora of nesting green turtles (Chelonia mydas) from Tortuguero National Park, Costa Rica. J Zoo Wildl Med., 37(4), 549–552. doi: 10.1638/05-118.1.

Schumacher, J. (2003). Reptile respiratory medicine. Vet Clin North Am Exot Anim Pract, 6(1), 213–231. doi: 10.1016/s1094-9194(02)00020-8.

Shine, R. (2013). Reptiles. Curr Biol., 23(6), R227–R231. doi: 10.1016/j.cub.2013.02.024.

Sodagari, H., Habib, I., Shahabi, M., Dybing, N., Wang, P., & Bruce, M. (2020). A Review of the Public Health Challenges of Salmonella and Turtles. VetSci., 7(2), 56. doi: 10.3390/vetsci7020056.

Tul, O. I., & Skrypka, M. V. (2016). Rezultaty mikrobiolohichnoho skryninhu bakterialnykh asotsiatsii yashchirky prudkoi na terytorii m. Poltava. Problemy zooinzhenerii ta veterynarnoi medytsyny, 33(2), 113–118 (in Ukrainian).

Vasil'ev, D. B. (2012). Cherepahi soderzhanie, bolezni i lechenie. Moskva: AKVARIUM-PRINT (in Russian).

Wang, W., Fang, H., Cui, Q., Ye, C., Gui, Y., Su, J., & Hao, L. (2020). First report of Salmonella Pomona infection in a young child associated with pet turtle exposure in Shanghai. Disease Surveillance, 35(10), 957–960. doi: 10.3784/j.issn.1003-9961.2020.10.018.

Wyneken, J., & Made, D. (2002). Anatomy and clinical applications of the renal portal system and the ventral abdominal vein in reptiles. Association of Reptilian and Amphibian Veterinarians, 183–186. URL: https://cdn.ymaws.com/members.arav.org/resource/resmgr/Files/Proceedings_2002/2002_50.pdf.

Yari, A., & Gharzi, A. (2013). Anatomical and Histological Study of the Excretory System in the Bosc’s Fringe-Toed Lizard (Acanthodactylus boskianus). Asian Journal of Animal Sciences, 7, 30–35. doi: 10.3923/ajas.2013.30.35.

Zancolli, G., Mahsberg, D., Sickel, W., & Keller, A. (2015). Reptiles as Reservoirs of Bacterial Infections: Real Threat or Methodological Bias? Microb Ecol., 70(3), 579–584. doi: 10.1007/s00248-015-0618-3.

Zwart, P. (1964). Studies on Renal Pathology in Reptiles. ZWART Studies on Renal Pathology in Reptiles, 542–556.

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Published
2021-04-05
How to Cite
Chuliuk, W. (2021). Features of the usage of antibiotics in herpetology. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 23(101), 61-66. https://doi.org/10.32718/nvlvet10111