The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure


Keywords: pharmacology, bendamin, heart failure, cardiomyopathy, dogs.

Abstract

Experimental studies obtained in recent years indicate the urgency of developing drugs of complex action to prevent the development of cardiovascular disease in dogs. This requires a much deeper study of the pathogenesis of heart failure, including cardiomyopathy. The aim of the study was to investigate the effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure. Two groups of dogs were formed for research: control (healthy) and experimental (sick). The 30-day experiment included 10 dogs of the control group and 10 dogs of the experimental (sick) breed of spaniel and dog 10–12 years of age. Treatment regimen for sick dogs: furosemide was administered orally on an empty stomach at 2 mg/kg every 12 hours; enalapril was administered orally at 0.5 mg/kg every 12 hours; bendamine was administered orally on an empty stomach at 20 mg/kg every 24 hours. It is recommended to divide the dose into two doses. An increase in the activity of aminotransferases (ALT by 59.2 %, AST – by 51.9 %) was found in the serum of dogs at heart failure. An increase in alkaline phosphatase activity was also found, which in the complex is an additional confirmation of changes in the heart muscle. Lactate dehydrogenase activity increased in the blood of sick dogs by 23.5 %. Minor changes in the content of total bilirubin and urea in the serum of sick dogs indicate the initial stage of liver pathology with impaired liver function due to congestion in the small circulation. This is also indicated by a decrease in the level of total protein in the blood of sick dogs, which was respectively 57.2 ± 3.57 g/l against the control group of 63.5 ± 4.15 g/l. On the basis of cardiac dysfunction and on the background of congestion, the function of not only the liver but also the kidneys is impaired (the so-called cardiorenal syndrome in heart failure). This is indicated by an increase in urea and creatinine by 38.5 and 36.9 %, respectively, compared with animals in the control group. The use of the drug “Bendamin” alleviated the manifestations of functional failure of the heart, liver and kidneys, as indicated by biochemical studies. Studies confirm the feasibility of using the drug “Bendamin” in dogs with the development of heart failure. The use of the drug “Bendamine” in patients with heart failure in dogs had a positive effect on the restoration of hematopoiesis and the normalization of biochemical parameters of the blood.

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References

Borgarelli, M., & Buchanan, J. W. (2012). Historical review, epidemiology and natural history of degenerative mitral valve disease. Journal of Veterinary Cardiology, 14(1), 93–101. doi: 10.1016/j.jvc.2012.01.011.

Borgarelli, M., Tarducci, A., Zanatta, R., & Haggstrom, J. (2007). Decreased systolic function and inadequate hypertrophy in large and small breed dogs with chronic mitral valve insufficiency. Journal of Veterinary Internal Medicine, 21(1), 61–67. doi: 10.1892/0891-6640(2007)21[61:dsfaih]2.0.co;2.

Borgarelli, M., Zini, E., D’Agnolo, G., Tarducci, A., Santilli, R. A., Chiavegato, D., Tursi, M., Prunotto, M., & Häggström, J. (2004). Comparison of primary mitral valve disease in German Shepherd dogs and in small breeds. Journal of Veterinary Car-diology, 6(2), 27–34. doi: 10.1016/S1760-2734(06)70055-8.

Chetboul, V., & Tissier, R. (2012). Echocardiographic assessment of canine degenerative mitral valve disease. Journal of Veterinary Cardiology, 14(1), 127–148. doi: 10.1016/j.jvc.2011.11.005.

Cornell, C. C., Kittleson, M. D., Torre, P. D., Haggstrom, J., Lom-bard, C. W., Pedersen, H. D., Vollmar, A., & Wey, A. (2004). Allometric scaling of M-mode cardiac measurements in normal adult dogs. Journal of Veterinary Internal Medicine, 18(3), 311–321. doi: 10.1892/0891-6640(2004)18<311:asomcm>2.0.co;2.

Fox, P. R. (2012). Pathology of myxomatous mitral valve disease in the dog. Journal of Veterinary Cardiology, 14(1), 103–126. doi: 10.1016/j.jvc.2012.02.001.

Hollmer, M., Willesen, J. L., Tolver, A., & Koch, J. (2017). Left atrial volume and function in dogs with naturally occurring myxomatous mitral valve disease. Journal of Veterinary Car-diology, 19(1), 24–34. doi: 10.1016/j.jvc.2016.08.006.

Keene, B. W., Atkins, C. A., Bonagura, J. D., Fox, P. R., Hägg-ström, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., & Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxom-atous mitral valve disease in dogs. Journal of Veteri-nary Internal Medicine, 33(3), 1127–1140. doi: 10.1111/jvim.15488.

Larouche-Lebel, E., Loughran, K. A., & Oyama, M. A. (2019). Echocardiographic indices and severity of mitral regurgitation in dogs with preclinical degenerative mitral valve disease. Journal of Veterinary Internal Medicine, 33(2), 489 –498. doi: 10.1111/jvim.15461.

Lavryshyn, Y. Y., Varkholyak, I. S., Martyschuk, T. V., Guta, Z. А., Ivankiv, L. B., Paladischuk, О. R., Murska, S. D., Gutyj, B. V., & Gufriy, D. F. (2016). The biological significance of the antioxidant defense system of animals body. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 18, 2(66), 100–111. doi: 10.15421/nvlvet6622.

Lopez-Alvarez, J., Elliott, J., Pfeiffer, D., Chang, Y.-M., Mattin, M., Moonarmart, W., Hezzell, M.J., & Boswood, A. (2015). Clinical Severity Score System in Dogs with Degenerative Mi-tral Valve Disease. Journal of Veterinary Internal Medicine, 29(2), 575–581. doi: 10.1111/jvim.12544.

Martyshuk, T. V. (2016). The influence of oxidative stress on the state of the antioxidant defense system in the organism of rats. Regulatory Mechanisms in Biosystems, 7(1), 8–12. doi: 10.15421/021602.

Martyshuk, T. V., & Hutyi, B. V. (2021). Imunofiziolo-hichnyi stan ta antyoksydantnyi potentsial orhaniz-mu porosiat za umov oksydatsiinoho stresu ta dii koryhuiuchykh chynnykiv: monohrafiia. Lviv: SPOLOM (in Ukrainian).

Martyshuk, T. V., Gutyj, B. V., & Vishchur, O. I. (2016). Level of lipid peroxidation products in the blood of rats under the influence of oxidative stress and under the action of liposomal preparation of ‘‘Butaselmevit’’, Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University, 6(2), 22–27. doi: 10.15421/201631.

Martyshuk, T. V., Gutyj, B. V., & Vishchur, O. I. (2018). Indicators of functional and antioxidant liver status of rats under oxidative stress conditions and on the action of the liposomal drug “Butaselmevit”. Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies, 20(89), 100–107. doi: 10.32718/nvlvet8919.

Martyshuk, T. V., Gutyj, B. V., Vishchur, O. I., & Todori-uk, V. B. (2019). Biochemical indices of piglets blood under the action of feed additive “Butaselmevit-plus”. Ukrainian Journal of Veterinary and Agricultural Sci-ences, 2(2), 27–30. doi: 10.32718/ujvas2-2.06.

Martyshuk, T., & Gutyj, B. (2019). Influence of feed additive “Butaselmevit-Plus” on antioxidant status of rats in conditions of oxidative stress. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Agricultural Sciences, 21(90), 76-81. doi: 10.32718/nvlvet-a9013.

Menciotti, G., Borgarelli, M., Aherne, M., Wesselowski, S., Haggstrom, J., Ljungvall, I., Lahmers, S. M., & Ab-bott, J. A. (2017). Mitral valve morphology assessed by three-dimensional transthoracic echocardiography in healthy dogs and dogs with myxomatous mitral valve disease. Journal of Veterinary Cardiology, 19(2), 113–123. doi: 10.1016/j.jvc.2017.01.002.

Merveille, A.-C., Bolen, G., Krafft, E., Roels, E., Gomart, S., Etienne, A.-L., Clercx, C., & Entee, K. Mc. (2015). Pulmonary Vein-to-Pulmonary Artery Ratio is an Echocardiographic Index of Congestive Heart Failure in Dogs with Degenerative Mitral Valve Disease. Journal of Veterinary Internal Medicine, 29(6), 1502–1509. doi: 10.1111/jvim.13634.

Morgan, K. R. S., Monteith, G., Raheb, S., Colpitts, M., & Fonfara, S. (2020). Echocardiographic parameters for the assessment of congestive heart failure in dogs with myxomatous mitral valve disease and moderate to severe mitral regurgitation. The Veterinary Journal, 263, 1–25. doi: 10.1016/j.tvjl.2020.105518.

Nazaruk, N. V., Gutyj, B. V., Gufrij, D. F., Leskiv, Kh. Ya., Ivashkiv, R. M., & Martyshuk, T. V. (2021). The ef-fect of methyphen and vitamix se on the level of products of bull lipid peroxide oxidation under nitrate-cadmium load. Colloquium-journal, 7(94), 16–18. doi: 10.24412/2520-6990-2021-794-16-18.

Oldach, M. S., Ueda, Y., Ontiveros, E. S., Fousse, S. L., Harris, S. P., & Stern, J. A. (2019). Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study. Front Vet Sci., 6, 15. doi: 10.3389/fvets.2019.00015.

Ramírez, V. L., Berrío, A., & Arias, M. P. (2016). Correlation between the clinical stage, echocardiographic findings and systemic blood pressure in dogs with Degenerative Disease of the Mitral Valve. CES Veterinary medicine and y Zootechnics, 11(2), 61–72. doi: 10.21615/cesmvz.11.2.5.

Reynolds, C. A., Brown, D. C., Rush, J. E., Fox, P. R., Nguyenba, T. P., Lehmkuhl, L. B., Gordon, S. G., Kellihan, H. B., Stepien, R. L., Lefbom, B. K., Meier, C. K., & Oyama, M. A. (2012). Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study. Journal of Veterinary Cardiology, 14(1), 193–202. doi: 10.1016/j.jvc.2012.01.008.

Tilley, P. L., Francis, W. K., Smith, J., Oyama, M.A. (2008). Manual of canine and feline cardiology. Copyright by Saunders, an imprint of Elsevier Inc, 105–106 (Fourth edition).

Tjostheim, S. S., Kellihan, H. B., Grint, K. A., & Stepien, R. L. (2019). Effect of sildenafil and pimobendan on intracardiac heartworm infections in four dogs. J Vet Cardiol., 23, 96–103. doi: 10.1016/j.jvc.2019.02.001.

Trofimiak, R., & Slivinska, L. (2021). Diagnostic value of echocardiographic indices of left atrial and ventricular morphology in dogs with myxomatous mitral valve disease (MMVD). Ukrainian Journal of Veterinary and Agricultural Sciences, 4(1), 16–23. doi: 10.32718/ujvas4-1.04.

Trofimjak, R., & Slivinska, L. (2016). Diagnosis of chronic heart failure dogs – existing methods and future prospects. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 18(71), 130–133. doi: 10.15421/nvlvet7129.

Undhad, V. V., Fefar, D. T., Jivani, B. M., Gupta, H., Ghodasara, D. J., Joshi, B. P. & Prajapati, K. S. (2012). Cardiac troponin: an emerging cardiac biomarker in animal health. Vet. World, 5, 508–511. doi: 10.5455/vetworld.2012.508-511.

Varcholyak, I. S., & Gutyi, B. V. (2019). Determination of the chronic toxicity of preparation “Bendamin” on laboratory animals. Theoretical and Applied Veteri-nary Medicine, 7(2), 63‒68. doi: 10.32819/2019.71011.

Varkholiak, I. S., & Gutyj, B. V. (2018). Determination of acute toxicity of “Bendamin” drug in laboratory animals. Scientific Messenger of Lviv National Uni-versity of Veterinary Medicine and Biotechnologies, 20(92), 209–212. doi: 10.32718/nvlvet9243.

Varkholiak, I. S., & Gutyj, B. V. (2019). The degree of cumulation of the “Bendamin” drug in the body of white rats. Scientific Messenger of Lviv National Uni-versity of Veterinary Medicine and Biotechnologies. Series: Veterinary sciences, 21(94), 82–85. doi: 10.32718/nvlvet9415.

Varkholiak, I. S., Gutyj, B. V., Leskiv, Kh. Ya., Kushnir, V. I., Hariv, I. I., Martyshuk, T. V., & Guta, Z. A. (2021). The effect of bendamine on antioxidant pro-tection of rats' myocardium in doxorubicin intoxica-tion. Colloquium-journal, 7(94), 18–21. doi: 10.24412/2520-6990-2021-794-18-21.

Varkholiak, I. S., Gutyj, B. V., Leskiv, Kh. Ya., Kushnir, V. I., Hariv, I. I., Martyshuk, T. V., & Guta, Z. A. (2021). The effect of bendamine on antioxidant pro-tection of rats' myocardium in doxorubicin intoxica-tion. Colloquium-journal, 7(94), 18‒21. doi: 10.24412/2520-6990-2021-794-18-21.

Varkholiak, I., Gutyj, B., & Leskiv, Kh. (2020). Influence of “Bendamin” on the indices of antioxidant protec-tion in rat’s blood by an experimental doxorubicin-induced cardiomyopathy. Scientific Light, 35, 41–44.

Varkholiak, I., Gutyj, B., Kushnir, V., Nazaruk, N., Lisnyak, O., & Yurynets, T. (2020). The effect of bendamine on the intensity of lipid peroxidation and the activity of the antioxidant defense system of blood in rats in experimental doxorubicin-induced cardiomyopathy. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(100), 36–40. doi: 10.32718/nvlvet10007.

Vlizlo, V. V., Fedoruk, R. S., & Raty`ch, I. B. (2012). Laboratorni metody` doslidzhen` u biologiyi, tvary`nny`cztvi ta vetery`narnij medy`cy`ni: dovidny`k. L`viv: Spolom (in Ukrainian).

Yata, M., Kooistra, H. S., & Beijerink, N. J. (2019). Cardiorenal and endocrine effects of synthetic canine BNP1-32 in dogs with compensated congestive heart failure caused by myxomatous mitral valve disease. J Vet Intern Med., 33(2), 462–470. doi: 10.1111/jvim.15416.

Zhulikova, O. A. (2016). Monitoring rasprostranenija serdechno-sosudistyh zabolevanij sredi koshek i sobak v g. Blagoveshhensk amurskoj oblasti. Dal'-nevostochnyj agrarnyj vestnik, 2(38), 49–56. https://cyberleninka.ru/article/n/monitoring-rasprostraneniya-serdechno-sosudistyh-zabolevaniy-sredi-koshek-i-sobak-v-g-blagoveschensk-amurskoy-oblasti (in Russian).

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Published
2021-04-05
How to Cite
Varkholiak, I., & Gutyj, B. (2021). The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 23(101), 93-99. https://doi.org/10.32718/nvlvet10116

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