“EMBIOTIC” Ltd. “EM-Ukraine” – an alternative to antibiotic therapy for digestive disorders in calves

  • Zh. V. Rybachuk Polissia National University, Zhytomyr, Ukraine https://orcid.org/0000-0003-2569-6721
  • I. V. Prisyazhnyuk Polissia National University, Zhytomyr, Ukraine
  • K. O. Chirta-Sinelnyk “EM-Ukraine” Limited Liability Company, Kropyvnytskyi, Ukraine
Keywords: feed additive “EMBIOTIK”, calves, diarrhea, carrying, prevention


The prophylactic efficacy of diarrhea in calves with different methods and doses of feed additive “EMBIOTIC” during the first 14 days of life was studied. Almost 50 % of dairy calves had symptoms of diarrhea. Effective treatment regimens for such animals included one of the antibiotics (azithromycin or 15 % amoxicillin emulsion) and, if necessary, sulfonamide drugs (trimeratinvet with the drugs sulfadimesine and trimethoprim) or the drug sulfate lozin, which includes sulfonamide and antibiotics (tylosin tartrate, oxytetracycline, sulfadimesine, trimethoprim). Simultaneously, symptomatic therapy was performed with the use of refinery – 10 % solution of ketoprofen in the form of the drug ketonil, which provided analgesia and reduction of body temperature to physiological limits. Еhere is always a drug cyanophore (LR butaphosphane and cyanocobalamin) as a general stimulant in the scheme. To conduct the experiment, 5 groups of animals were formed, 6 in each, age – the first day after birth. From the first to the 14th day of life, from the first or second colostrum, each calf from different groups was given daily 5 cm3, 10 cm3 and 15 cm3 of feed additive “EMBIOTIC”, respectively. The fourth experimental group – control (probiotic was not received), and the fifth – calves obtained from cows, which 10–14 days before and after calving daily with feed or water received 80–100 cm3 of feed additive “EMBIOTIC”, and calves the tested drug was not used. During the experiment twice a day (morning and evening), clinical observation and examination of calves of all experimental groups. Two days later, calves that received 5 cm3, 10 cm3 and 15 cm3 of feed additive “EMBIOTIC” were registered to improve appetite, increased mobility and prolonged and pronounced sleep. In animals that received with milk 10 cm3 and 15 cm3 of feed additives, during the observation period, disorders of the digestive system were not registered. Two calves, receiving 5 cm3 of EMBIOTICS daily, had symptoms of minor diarrhea for only 12 days, but there was no appetite. After 24 hours, the symptoms of indigestion went away on their own without the use of any drugs. Newborn calves obtained from cows that received “EMBIOTIC” as part of their diet or water were rated 9–10 on the Apgar scale. From the 3rd day they ate straw and they registered chewing gum for 3.7 ± 0.2 days of life. Within 14 days of observation of disorders of the gastrointestinal tract, they were not registered. Thus, the feed additive “EMBIOTIC” provides prevention of diarrhea in calves.


Download data is not yet available.


Barua, S. R., Rakib, T. M., Rahman, M. M., Selleck, S., Masuduzzaman, M., Siddiki, A. Z. & Chowdhury, S. (2019). Disease burden and associated factors of ro-tavirus infection in calves in south-eastern part of Bangladesh. Asian Journal of Medical and Biological Research, 5(2), 107–116. doi: 10.3329/ajmbr.v5i2.42492.

Bernaola Aponte, G., Bada Mancilla, C. A., Carreazo Pariasca, N. Y., & Rojas Galarza, R. A. (2008). Probi-otics for treating per sistentdi arrhoea in children. Cochrane Data base of Systematic Reviews. doi: 10.1002/14651858.cd007401.

Bindels, L. B., Delzenne, N. M., Cani, P. D., & Walter, J. (2015). Towards a more comprehen sive concept for prebiotics. Nature Reviews Gastroenterology & Hepa-tology, 12(5), 303–310. doi: 10.1038/nrgastro.2015.47.

Dereje, W. (2012). Isolation and identification of Entero-bacteria species from diarrheic calves in and around Addis Ababa. Ethiopia, 6(1), 2474–7637.

Duc, L. H., Hong, H. A., Barbosa, T. M., Henriques, A. O., &Cutting, S. M. (2004). Characterization of Bacillus Probiotics Available for Human Use. Applied and En-vironmental Microbiology, 70(4), 2161–2171. doi: 10.1128/aem.70.4.2161-2171.2004.

Floch, M. H., Walker, W. A., Sanders, M. E., Nieuwdorp, M., Kim, A. S., Brenner, D. A., Qamar, A. A., Miloh, T. A., Guarino, A., Guslandi, M., Dieleman, L. A., Ringel, Y. Quigley, E. M. M., & Brandt, L. J. (2015). Recom-mendations for Probiotic Use–2015 Update. Journal of Clinica Gastroenterology, 49, 69–73. doi: 10.1097/mcg.0000000000000420.

Goharshahi, M., Azizzadeh, M., Lidauer, L., Steininger, A., Kickinger, F., Öhlschuster, M., ... & Iwersen, M. (2021). Monitoring selected behaviors of calves by use of an ear-attached accelerometer for detecting early indicators of diarrhea. Journal of Dairy Science, 104(5), 6013–6019. doi: 10.3168/jds.2020-18989.

Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., Morelli, L., Canani, R. B., Flint, H. J. Salminen, S., Calder P. C., & Sanders, M. E. (2014). The International Scientific Association for Probiotic sand Prebiotic sconsens us statementon the scope and appropriateuse of thetermprobiotic. Nature Reviews Gastroenterology & Hepatology, 11(8), 506–514. doi: 10.1038/nrgastro.2014.66.

Jia, P., Cui, K., Ma, T., Wan, F., Wang, W., Yang, D., Wang, Y., Guo, B., Zhao, L., & Diao, Q. (2018). Influ-ence of dietary supplementation with Bacillus licheni-formis and Saccharomyces cerevisiae as alternatives to monensin on growth performance, antioxidant, immunity, ruminal fermentation and microbial diver-sity of fattening lambs. Scientific reports, 8(1), 16712. doi: 10.1038/s41598-018-35081-4.

Medrano-Galarza, C., LeBlanc, S. J., Jones-Bitton, A., DeVries, T. J., Rushen, J., de Passillé, A. M., … & Ha-ley, D. B. (2018). Associations between management practices and within-pen prevalence of calf diarrhea and respiratory disease on dairy farms using auto-mated milk feeders. Journal of dairy science, 101(3), 2293–2308. doi: 10.3168/jds.2017-13733.

Mohammed, S. A. E. M., Marouf, S. A. E. M., Erfana, A. M., El, J. K. A. E. H., Hessain, A. M., Dawoud, T. M., & Moussa, I. M. (2019). Risk factors associated with E. coli causing neonatal calf diarrhea. Saudi journal of biological sciences, 26(5), 1084–1088. doi: 10.1016/j.sjbs.2018.07.008.

Monney, J. D., Adjogoua, E. V., Karamoko, Y., &Akran, A. (2020). Incidences of Calf Diarrhea and the Asso-ciated Risk Factors in Ivory Coast (2015–2017). Re-vista de Ciências Agroveterinárias, 19(4), 454–461. doi: 10.5965/223811711942020454.

Pokhylko, Y. M., & Kravchenko, N. O. (2018). Recovery and correction of the balance of microbiota of the gastrointestinal tractofrabbits, disabledasresulting from theuse of antibiotics. Bìoresursi ì Pri-rodokoristuvannâ, 10(3–4). doi: 10.31548/bio2018.03.003.

Temesgen, W. (2004). Calf morbidity and mortality in dairy farms in DebreZeit and its Environs. Scientific reports. 2018. R. 157.

Tsukano, K., Sarashina, S., & Suzuki, K. (2018). Hypo-glycemia and failure of respiratory compensation are risk factors for mortality in diarrheic calves in Hok-kaido, northern Japan. Journal of Veterinary Medical Science, 80(7), 1159–1164. doi: 10.1292/jvms.18-0109.

Whon, T. W., Kim, H. S., Shin, N. R., Sung, H., Kim, M. S., Kim, J. Y., ... & Bae, J. W. (2021). Calf Diarrhea Caused by Prolonged Expansion of Autochthonous Gut Enterobacteriaceae and Their Lytic Bacterio-phages. Msystems, 6(2). doi: 10.1128/mSystems.00816-20.

Yeshiwas, T., & Fentahun, W. M. (2017). The Prevalence of E. coli From Diarrheic Calves and Their Antibiotic Sensitivity Test in Selected Dairy Farms of Debre Zeit, Ethiopia. Adv Biotech & Micro, 6(1), 555680. doi: 10.19080/AIBM.2017.06.555680.

Rybachuk, Zh. V., Shkromada, O. I., Predko, A. V., Dud-chenko, Ju. A. (2020). Vplyv probiotyka “Imunobak-teryn-D” na biocenoz ta rozvytok shlunkovo-kyshkovogo traktu teljat. Naukovyjvisnyk LNUVMB imeni S.Z. G'zhyc'kogo. Serija: Veterynarni nauky, 22(98), 22–27. doi: 10.32718/nvlvet9804 (in Ukrainian).

Sorokina, N. G. (2002). Dysbakterioz shlunkovo-kyshkovogo traktu novonarodzhenyh teljat, metody jogo korekcii' ta profilaktyky: avtoreferat. Kyi'v (in Ukrainian).

Abstract views: 62
PDF Downloads: 33
How to Cite
Rybachuk, Z. V., Prisyazhnyuk, I., & Chirta-Sinelnyk, K. (2021). “EMBIOTIC” Ltd. “EM-Ukraine” – an alternative to antibiotic therapy for digestive disorders in calves. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 23(102), 8-13. https://doi.org/10.32718/nvlvet10202