Pathomorphological diagnostics of panleukopenia in cats (case description)


  • O. Rudenko Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Lviv, Ukraine
  • O. Shchebentovska Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Lviv, Ukraine https://orcid.org/0000-0002-7778-1939
Keywords: dehydration, intracytoplasmic inclusion bodies, crypts of Lieberkühn, splenomegaly, lymphocytic necrosis

Abstract

The article highlights the results of autopsy and histopathological studies of cats diagnosed with panleukopenia (FPV), confirmed by immunochromatographic rapid test. The spread of FPV among cats is declining sharply worldwide due to domestic vaccination of cats. However, the number of deaths among homeless animals is still high. The disease course usually varies from subclinical infection to acute syndrome with sudden death. Typical clinical manifestations are characterized by fever, lethargy, and anorexia. Sick cats suffer from vomiting and subsequent watery or hemorrhagic diarrhea. Homeless animals often die from complications associated with secondary bacterial infection, sepsis, and dehydration. Cats aged four months to one year are the most severely affected. Mortality varies depending on the disease course, the animal’s general condition, and timely veterinary care. The autopsy of the dead animals showed signs of catarrhal gastritis, catarrhal and hemorrhagic enterocolitis, splenomegaly, serous lymphadenitis, liver and kidneys’ acute congestive hyperemia, and pulmonary edema. Duodenum histological examination revealed villi necrosis, edema of the mucous membrane’s stroma, and desquamation of enterocytes into the intestinal lumen. Necrosis of Lieberkühn crypts and viral intracytoplasmic inclusions in enterocytes were very pronounced. Microscopic changes in the stomach and large intestine were characterized by dystrophic and necrobiotic changes of mainly the epithelial plate of the mucous membrane. Extracapillary glomerulonephritis developed in the kidneys, while focal emphysema and edema occured in the lungs. Stroma edema, delimphatization and lymphocytic necrosis were observed in the spleen and lymph nodes.

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Published
2022-05-04
How to Cite
Rudenko, O., & Shchebentovska, O. (2022). Pathomorphological diagnostics of panleukopenia in cats (case description). Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 24(105), 59-66. https://doi.org/10.32718/nvlvet10509