The effectiveness of treatment for dirofilariasis in dogs
Livestock industry – dog breeding is of great importance in human activities. Infectious and invasive diseases are a deterrent to the breeding and improvement of dog breeds. Not only do they cause significant economic damage to dog breeding, but they can also be dangerous to humans. Such diseases include dirofilariasis – an invasive disease that is transmitted through intermediate hosts – blood-sucking mosquitoes. The urgency of dirofilariasis is also due to the difficulties of therapy, because effective drugs of imported production are not available due to high cost, and the arsenal of domestic counterparts is small. The aim of the study was to establish the effectiveness of various treatment regimens for dog dirofilariasis. For this purpose, dogs infected with Dirofilaria immitis used specific drugs immiticide (AS – melarsomin), stronghold (AS – selamectin), doxycyl (AS – doxycyclini hydrochloridum), advocate (AS – imidacloprid, moxidectin). The main indicators of the effect of drugs were extensefficiency and intensefficiency. Studies have shown that with the intensity of microdirofilariasic invasion below 20 larvae in 1 cm3 of dog blood and in the absence of clinical manifestations of the disease extensefficiency and intensefficiency of concomitant use of immiticide and stronghold, doxycyl and stronghold, immiticide and advocate, doxycyl and advocate on the 15th day of the experiment was 100.0 %, 100.0 %, 100.0 %, 83.33 and 86.81 % respectively. With the intensity of microdirofilariasic invasion from 20 to 40 larvae in 1 cm3 of dog blood, the extensefficiency and intensefficiency of the proposed treatment regimens were respectively 100.0 %, 83.33 and 88.46 %, 66.66 and 82.54 %, 66.66 and 80.20 %. On the 180th day of treatment and during the year in all experimental groups of dogs, regardless of the intensity of the invasion of microdirofilariae in the blood of animals were not detected. Immunochromatographic rapid test, starting from 30 days of the experiment, was negative for adult females of D. immitis. The results of the research allow us to recommend the proposed treatment regimens in the effective control of dog dirofilariasis caused by D. immitis.
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