TOXICITY STUDY OF «AMPROLINSILE» IN CHRONIC EXPERIMENT


  • V. Stybel Lviv National University of Veterinary Medicine and Biotechnologies
  • I. Chariv Lviv National University of Veterinary Medicine and Biotechnologies
  • B. Gutyj Lviv National University of Veterinary Medicine and Biotechnologies
  • D. Hufriy Lviv National University of Veterinary Medicine and Biotechnologies
Keywords: pharmacology, cumulation, brovitacoccides, «Amprolinsile», Silybum marianum, turkeys, eimeria, histomonades

Abstract

The article reviews the results of experimental searches of the toxicity of «Amprolinsile» in chronic experiments on laboratory animals. It was established that the drug in doses 1/50 DL50 and 1/100 DL50 had no influence on theresults of functional tests, due to the normal functioning of liver tissue and the lack of negative influence  on animals body from 3rd  and 4th  groups. After drug injection at doses 1/20 DL50, 1/50 DL50and 1/100 DL50 for 30 days hadn’t significantly influence on  the functional state of internal organs of experimental animals. For the search of morphological indices of rats blood after oral injection of  «Amprolinsile» in different doses, it was set up the tendency tohemoglobin level reduction and values of color index and the reliable  reduction in the number of white blood cells, compared with the control group, in all experimental groups. It was also established that the values of haematological and biochemical indices, despite of the low toxicity, «Amprolinsile» at a dose of 1/20 and 1/50 DL50  had an influence on lipid metabolism, that testifies the increase of glycerol.


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Abstract views: 52
PDF Downloads: 34
Published
2015-03-09
How to Cite
Stybel, V., Chariv, I., Gutyj, B., & Hufriy, D. (2015). TOXICITY STUDY OF «AMPROLINSILE» IN CHRONIC EXPERIMENT. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 17(2), 221-227. Retrieved from https://nvlvet.com.ua/index.php/journal/article/view/494