TOXICITY STUDY OF «AMPROLINSILE» IN CHRONIC EXPERIMENT
Abstract
The article reviews the results of experimental searches of the toxicity of «Amprolinsile» in chronic experiments on laboratory animals. It was established that the drug in doses 1/50 DL50 and 1/100 DL50 had no influence on theresults of functional tests, due to the normal functioning of liver tissue and the lack of negative influence on animals body from 3rd and 4th groups. After drug injection at doses 1/20 DL50, 1/50 DL50and 1/100 DL50 for 30 days hadn’t significantly influence on the functional state of internal organs of experimental animals. For the search of morphological indices of rats blood after oral injection of «Amprolinsile» in different doses, it was set up the tendency tohemoglobin level reduction and values of color index and the reliable reduction in the number of white blood cells, compared with the control group, in all experimental groups. It was also established that the values of haematological and biochemical indices, despite of the low toxicity, «Amprolinsile» at a dose of 1/20 and 1/50 DL50 had an influence on lipid metabolism, that testifies the increase of glycerol.
Downloads
References
Hariv, I.I. (2011). Stan imunnoi' systemy indykiv, urazhenyh asociatyvnoju ejmeriozo-gistomonoznoju invazijeju. / Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij imeni S.Z. Gzhyc'kogo. 13, 4 (50). 1, 481–485. (in Ukrainian).
Hariv, I. I. (2012). Vplyv brovitakokcydu i plodiv roztoropshi pljamystoi' na aktyvnist' fermentiv u syrovatci krovi indykiv, urazhenyh asociatyvnoju ejmeriozo-gistomonoznoju invazijeju / Visnyk Zhytomyrs'kogo nacional'nogo agroekologichnogo universytetu veterynarna medycyna . Zhytomyr. 1 (32). 3, 1, 98–102. (in Ukrainian).
Hariv, I. I. (2012). Biloksyntyzuval'na funkcija pechinky v intaktnyh indykiv na tli dii' brovitakokcydu i plodiv roztoropshi pljamystoi' / Naukovo-tehnichnyj bjuleten' Instytutu biologii' tvaryn i Derzhavnogo naukovo-doslidnogo kontrol'nogo instytutu vetpreparativ ta kormovyh dobavok. L'viv, 13, 3–4 , 258–262. (in Ukrainian).
Timofeev, B. A. (2004). Jejmerioz ptic / Veterinarnyj konsul'tant. – M., 5, 6–10. (in Russian).
Prydybajlo, N. D. (1991). Immunodeficity u sel'skohozjajstvennyh zhivotnyh i ptic, profilaktika i lechenie ih immunomoduljatorami / Dokl. VASHNIL. 12, 44–45. (in Russian).
Rui, G. C. (1991). Advances in pharmacological studies of silimarin / Met. Inst. Oswaedo. Crur. 86, 2205–2211.
Kocjumbas, I.Ja. (2006). Doklinichni doslidzhennja veterynarnyh likars'kyh zasobiv / I.Ja. Kocjumbas i spivavtory. – L'viv: Triada pljus, 360 s. (in Ukrainian).
Kosenko, M. V., Malyk, O. G., Kocjumbas, I. Ja., Paterega, I. P., Chura, D. O. (1997). Toksykologichnyj kontrol' novyh zasobiv zahystu tvaryn: Metodychni rekomendacii'. – K., 34 s. (in Ukrainian).
Malanin, L. P., Morozov, A. P., Selivanova, A. S. (1988). Metodicheskie ukazanija po opredeleniju toksicheskih svojstv preparatov, primenjaemyh v veterinarii i zhivotnovodstve / Veterinarnye preparaty: Spravochnik / Pod red. A. D. Tret'jakova. – M.: Agropromizdat, 239–289. (in Russian).
Hariv, I. I. (2013). Doslidzhennja toksychnosti «Amprolinsylu» / Naukovo-tehnichnyj bjuleten' Instytutu biologii' tvaryn i Derzhavnogo naukovo-doslidnogo kontrol'nogo instytutu vetpreparativ ta kormovyh dobavok. 14, 3, 120–124. (in Ukrainian).
Abstract views: 52 PDF Downloads: 34
This work is licensed under a Creative Commons Attribution 4.0 International License.
