IMMUNOLOGICAL BLOOD PARAMETERS OF CALVES WITH THE USE OF ARSELAN
Abstract
Objective of this work is to examine the features of formation of nonspecific resistance using fully integrated arselan immunostimulant comprising: selenite, sodium selenite, potassium, interferon, silver nanoparticles, nanoparticles of iron, copper nanoparticles, retinol acetate, cholecalciferol, α-tocopherol acetate. The studies were performed on calves of a black-motley breed. The drug was injected intramuscularly at a dose of 2 ml / head 2-5 and 14 days after birth. During the experiment the hygienic conditions of the calves, their survival and growth rate were taken into account. In order to assess the immune status of the organism, T- and B-lymphocytes in peripheral blood were determined. It was found that parenteral use of immunostimulatory drugs contributed to activation of antigen specific immunity of animals, such as increase of immune cells functional activity: accelerates the proliferation, differentiation of T-lymphocytes by 26.6 %, increases the activity of T-cells by 19.6 % and theophylline resistant ones by 32 %, increases the number of B-lymphocytes by 8.1%, the activity of plasma membrane receptor system by 12%. The above mentioned biological drug contributed to intensive growth of live body weight by 12–15 %, additional growth by 1.8–2 kg and survival of 90-100% of animals.
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