THE INFLUENCE OF METISEVIT AND METIFEN ON THE INTENSITY OF LIPID PER OXIDATION IN THE BLOOD OF BULLS ON NITRATE LOAD


  • B.V. Gutyj
  • D.F. Hufriy
  • V.M. Hunchak
  • I.I. Khariv
  • N.D. Levkivska
  • V.О. Huberuk
Keywords: toxicology, nitrates, lipid per oxidation, bulls blood

Abstract

The level of primary and secondary lipid per oxidation products were investigated: diene conjugates and malondialdehyde in conditions of nitrate loading. It was established that at bulls feeding with sodium nitrite at a dose of 0.2 hNO3ˉ/kg of body weight, the level of diene conjugates and malondialdehyde in their was increased during the entire the experiment. On the 30thday of the experiment the level of diene conjugates in blood of bull, which were conducted with nitrate load was 7.44 ± 0.15 mmol/l, and the level of malondialdehyde – 0.305 ± 0.014 mmol/l.

Under conditions of nitrate load , young cattle was used a new integrated drug «Metisevit», which consists of sodium selenite, vitamin E and metifen. It was found the stimulating effect of metifen and metisevit on antioxidant system of the body of young cattle. Depressing effect of metifen and metisevit on the processes and lipid per oxidation in the blood of bulls under conditions of chronic nitrate–nitrite toxicity. Metifen and metisevit interact with radicals of fatty acids and delay the development of a chain reaction of oxidative stress, reduce the oxidation of phospholipids and form a biologically inactive compound with products of per oxidation of fats. Obtained results of the research indicate antioxidant drugs «Metisevit» and «Metifen» in the application of their young cattle.

The mentioned changes are occurring through the comprehensive action of the drug components «Medisvit», that leads to the normalization of metabolic processes and free radical in the body of bulls. Obtained results of the research indicate the antioxidant action of the drugs «Metisevit» and «Metifen» in the application of their young cattle and the reasonableness of their administration to improve the antioxidant status of the organism according to nitrate loading.


Downloads

Download data is not yet available.

References

Baglaj, O.M., Murs'ka, S. D., Gutyj, B.V., Gufrij, D.F. (2011). Systema antyoksydantnogo zahystu ta perekysne okysnennja lipidiv organizmu tvaryn. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 13, 4(2), 3–11 (in Ukrainian).

Guberuk, V.O., Gutyj, B.V., Gufrij, D.F. (2015). Vplyv Ursovit–ADES ta selenitu natriju na aktyvnist' enzymiv glutationovoi' systemy antyoksydantnogo zahystu organizmu bychkiv pry gostromu nitratno–nitrytnomu toksykozi. Visnyk Sums'kogo nacional'nogo agrarnogo universytetu. Serija : Veterynarna medycyna. 1, 151–154 (in Ukrainian).

Guberuk, V.O., Gutyj, B.V., Gufrij, D.F. (2015). Vplyv ursovit–ades ta selenitu natriju na riven' neenzymnoi' systemy antyoksydantnogo zahystu organizmu bychkiv za gostrogo nitratno–nitrytnogo toksykozu. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 17, 1(1), 3–10 (in Ukrainian).

Guberuk, V.O., Gutyj, B.V., Murs'ka, S.D., Gufrij, D.F. (2012). Riven' nefermentnoi' systemy antyoksydantnogo zahystu organizmu bychkiv pry gostromu nitratno–nitrytnomu toksykozi. Biologija tvaryn. 14(1–2), 300–305 (in Ukrainian).

Gunchak, V.M., Gufrij, D.F., Gutyj, B.V., Vasiv, R.O., Hariv, I.I., Homyk, R.I., Guberu, V.O. (2010). Vplyv gostrogo nitratno–nitrytnogo toksykozu na aktyvnist' systemy antyoksydantnogo zahystu ta intensyvnist' perekysnogo okysnennja lipidiv u krovi bugajciv. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 12, 3(1), 35–43 (in Ukrainian).

Gunchak, V.M., Gufrij. D.F., Gutyj, B.V., Vasiv, R.O., Hariv, I.I., Homyk, R.I., Murs'ka, S.D., Guberuk, V.O. (2010). Vplyv nitratu natriju u toksychnyh dozah na systemu antyoksydantnogo zahystu ta perekysne okysnennja lipidiv u krovi bugajciv. Biologija tvaryn. 12(1), 151–158 (in Ukrainian).

Gutyj, B.V. (2013). Riven' pokaznykiv nefermentnoi' systemy antyoksydantnogo zahystu organizmu bychkiv za umov kadmijevogo navantazhennja. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 15, 1(4), 40–45 (in Ukrainian).

Khariv, M., Gutyj, B., Butsyak, V., Khariv, I. (2016). Hematological indices of rat organisms under conditions of oxidative stress and liposomal preparation action. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6(1), 276–289.

Martyshuk, T.V., Gutyj, B.V., Vishchur, O.I. (2016). Level of lipid peroxidation products in the blood of rats under the influence of oxidative stress and under the action of liposomal preparation of «Butaselmevit», Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6(2), 22–27.

Nazaruk N.V., Gutyj, B.V., Gufrij, D.F. (2015). Vplyv metifenu ta vitamiksu se na aktyvnist' aminotransferaz syrovatky krovi bychkiv za nitratno–kadmijevogo navantazhennja. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 17, 1(1), 121–126 (in Ukrainian).

Nazaruk, N.V., Gutyj, B.V., Murs'ka, S.D., Gufrij, D.F. (2016). Vplyv metifenu ta vitamiksu Se na riven' vitaminiv A i E u krovi bychkiv za nitratno–kadmijevogo navantazhennja. Visnyk Sums'kogo nacional'nogo agrarnogo universytetu. Serija Veterynarna medycyna. 6, 27–30 (in Ukrainian).

Staryk, L.I., Gutyj, B.V., Vasiv, R.O., Gufrij, S.D. Murs'ka, D.F. (2012). Vplyv sukupnogo vvedennja pirydoksynu gidrohlorydu z askorbinovoju kyslotoju na biohimichni ta morfologichni pokaznyky krovi bychkiv pry gostromu nitratno–nitrytnomu toksykozi. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 14, 2(1), 306–312 (in Ukrainian).

Abstract views: 127
PDF Downloads: 48
Published
2016-09-07
How to Cite
Gutyj, B., Hufriy, D., Hunchak, V., Khariv, I., Levkivska, N., & Huberuk, V. (2016). THE INFLUENCE OF METISEVIT AND METIFEN ON THE INTENSITY OF LIPID PER OXIDATION IN THE BLOOD OF BULLS ON NITRATE LOAD. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 18(3(70), 67-70. https://doi.org/10.15421/nvlvet7015

Most read articles by the same author(s)