TELOMER THEORY OF AGING OF CELL


  • O. Stakhiv Lviv National University of Veterinary Medicine and Biotechnologies named after S.Z. Gzhytskyj
  • N. Shemediuk Lviv National University of Veterinary Medicine and Biotechnologies named after S.Z. Gzhytskyj
Keywords: aging, telomer theory, telomers, telomeraza, proliferation of cell, cellular cycle, DNA, replication of DNA, underreplication

Abstract

Among the row of theories that explain the phenomen on of aging, the large attention of the modern scientific world is turn to ed a side of telomer theory. From this point of view, aging is a result of damage to the genetic apparat. A process is programed and relatedto expression of genes of old «age» on the certain stage of ontogenesis, that are  reason  destructive  changes in a cell. The presence Heynflick`s limit and telomer meter of division of cell sustains this theory. The telomere theory of aging has research of intercommunication of akey moments between the type of cells, presence in a functionally active telomeraza and by stopping of cellular cycle. The telomeraza mechanism of action is building of  sequences of  nucleotide  in  the  areas of DNA, that is lost with every division of cells. Disruption of the body is a result of the telomere shortening after every cycle of DNA replication. It doesn’t depend on time, but from the amount of replication of DNA and it can be replicometr, that determines the amount of cell divisions. After the achievement critical length of telomeric DNAsegments a cellular cycle is stopped in G1 or G2/M phases. Enzyme contains TERT (telomerase reverse transcriptase), TER (telomerase RNA). An important catalytic domen which inherent reverse transcriptases, domen of joining TER, DNA–substrate, are part of TERT. Onthis  time question of searching activators of telomeraza is actual, sciens are interested in it so that number of advanced studies are increase every year. 

 

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Abstract views: 107
PDF Downloads: 207
Published
2016-10-11
How to Cite
Stakhiv, O., & Shemediuk, N. (2016). TELOMER THEORY OF AGING OF CELL. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 18(3(71), 109-111. https://doi.org/10.15421/nvlvet7125