TELOMER THEORY OF AGING OF CELL
Among the row of theories that explain the phenomen on of aging, the large attention of the modern scientific world is turn to ed a side of telomer theory. From this point of view, aging is a result of damage to the genetic apparat. A process is programed and relatedto expression of genes of old «age» on the certain stage of ontogenesis, that are reason destructive changes in a cell. The presence Heynflick`s limit and telomer meter of division of cell sustains this theory. The telomere theory of aging has research of intercommunication of akey moments between the type of cells, presence in a functionally active telomeraza and by stopping of cellular cycle. The telomeraza mechanism of action is building of sequences of nucleotide in the areas of DNA, that is lost with every division of cells. Disruption of the body is a result of the telomere shortening after every cycle of DNA replication. It doesn’t depend on time, but from the amount of replication of DNA and it can be replicometr, that determines the amount of cell divisions. After the achievement critical length of telomeric DNAsegments a cellular cycle is stopped in G1 or G2/M phases. Enzyme contains TERT (telomerase reverse transcriptase), TER (telomerase RNA). An important catalytic domen which inherent reverse transcriptases, domen of joining TER, DNA–substrate, are part of TERT. Onthis time question of searching activators of telomeraza is actual, sciens are interested in it so that number of advanced studies are increase every year.
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