TY - JOUR AU - Ye. Mostovyi AU - V. Holovakha AU - O. Piddubniak AU - S. Sliusarenko AU - A. Sliusarenko AU - M. Samorai PY - 2020/08/22 Y2 - 2024/03/29 TI - The treating dogs for enteropathy with PLE JF - Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences JA - nvlvet VL - 22 IS - 98 SE - Articles DO - 10.32718/nvlvet9817 UR - https://nvlvet.com.ua/index.php/journal/article/view/3983 AB - One of the most common and poorly understood diseases in dogs and cats is enteropathy with PLE.  The disease occurs, according to studies, in dogs of 2-6 years old breeds: Yorkshire terrier, German shepherd, and Golden Retriever. The disease in most cases is manifested by anorexia, polydipsia, diarrhea, fever up to 39.7 °C, tachycardia (145–170 bpm), and abdominal pain. In sick dogs, leucocytosis (21.0 ± 0.50 g/l), thrombocytosis (480.0 ± 10.13 g/l), oligocythaemia (4.8 ± 0.12 T/l), oligochromemia (109.0 ± 5.06 g/l), decrease in haematocrit value (29.0 ± 1.21 % in healthy people 42.3 ± 0.65 %). In a biochemical study of blood in dogs with enteropathy with PLE, hypoproteinaemia (38.2 ± 0.65 g/l), hypoalbuminemia (9.6 ± 0.61 g/l); hyperazotemia (8.6 ± 0.37 mmol/l), hypercholesterolemia (8.0 ± 0.23 mmol/l), hyperenzymemia of LF (ALP) and ALT (alanine aminotransferase), hyponatremia, hypokalaemia, hypochloraemia, decreased blood pH values (7.26 ± 0.013), HCO3- (15.3 ± 0.71 mmol/L) and AG (2.85 ± 0.084 mmol/L, in healthy people 14.3 ± 1.17 mmol/L). The diagnosis of enteropathy with PLE was confirmed by studies in feces of α1-antitrypsin, which in sick dogs with PLE was more than 22 mg/dL (in clinically healthy dogs up to 18 mg/dL). A treatment regimen with trometamol, Xylat, Disparkol, Voluven, Reopoliglukin, Maropitant, prednisolone, α-lysine escinat, albumin, Presorb and feed additives Vivonex Ten Elemental and Royal Canin Recoveri promotes the recovery of dogs, prevents their death. Under the action of drugs, erythro- and leuсocytopoiesis, protein-synthesizing (the content of total protein and albumin increased by 34.3 and 246.9 %, respectively) and urea-forming functions of hepatocytes improves. We have developed and tested a treatment scheme that restores the acid-base balance of the body, as indicated by the physiological values of blood pH, bicarbonates, anion gap (AG), Na+, K+, Cl- and Mg+. ER -